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• W42705890 abstract "Purpose of review This review focuses on current understanding of molecular mechanisms operating within erythroblastic islands including cell–cell adhesion, regulatory feedback, and central macrophage function. Recent findings Erythroblasts express a variety of adhesion molecules and recently two interactions have been identified that appear to be critical for island integrity. Erythroblast macrophage protein, expressed on erythroblasts and macrophages, mediates cell–cell attachments via homophilic binding. Erythroblast intercellular adhesion molecule-4 links erythroblasts to macrophages through interaction with macrophage αv integrin. In intercellular adhesion molecule-4 knockout mice, erythroblastic islands are markedly reduced, whereas the erythroblast macrophage protein null phenotype is severely anemic and embryonic lethal. Retinoblastoma tumor suppressor (Rb) protein stimulates macrophage differentiation by counteracting inhibition of Id2 on PU.1, a transcription factor that is a crucial regulator of macrophage differentiation. Rb-deficient macrophages do not bind Rb null erythroblasts and the Rb null phenotype is anemic and embryonic lethal. Lastly, extruded nuclei rapidly expose phosphatidylserine on their surface, providing a recognition signal similar to apoptotic cells. Summary Although understanding of molecular mechanisms operating within islands is at an early stage, tantalizing evidence suggests that erythroblastic islands are specialized niches where intercellular interactions in concert with cytokines play critical roles in regulating erythropoiesis." @default.
• W42705890 created "2016-06-24" @default.
• W42705890 creator A5044277046 @default.
• W42705890 date "2006-05-01" @default.
• W42705890 modified "2023-10-12" @default.
• W42705890 title "Erythroblastic islands: specialized microenvironmental niches for erythropoiesis" @default.
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• W42705890 doi "https://doi.org/10.1097/01.moh.0000219657.57915.30" @default.
• W42705890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16567955" @default.
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