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- W42764928 abstract "Background Particle size is a determinant of Fe absorption from poorly-soluble Fe compounds. Decreasing the particle size of metallic Fe added to foods increases Fe absorption. Objective To develop and characterize nanoparticles of ferric phosphate and to determine their bioavailability in rats. Design Amorphous FePO4 nanopowders with spherical structure were synthesized by flame spray pyrolysis. They were characterized and compared to commercially available FePO4 and FeSO4, including measurements of specific surface area (SSA), in-vitro solubility, and relative bioavailability to FeSO4 (RBV) in rats. In the latter, their potential toxicity was assessed. Results The commercial ‘large’ FePO4 and the ‘medium’ and ‘small’ FePO4 produced by flame spray pyrolysis had the following characteristics, respectively: SSA: 32.6, 68.6, 194.7 m2/g; solubility after 30 min at pH 1: 73, 79 and 85% of FeSO4; and RBV, 61, 70 and 96%. There were no indications of toxicity. Conclusion Nanoparticles of FePO4 have a solubility and RBV similar to FeSO4. Reducing poorly-soluble Fe compounds to nanoscale may increase their potential value for human nutrition." @default.
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- W42764928 date "2007-01-01" @default.
- W42764928 modified "2023-10-18" @default.
- W42764928 title "Synthesis, characterization and bioavailability of ferric phosphate nanoparticles" @default.
- W42764928 doi "https://doi.org/10.1096/fasebj.21.6.a1113-c" @default.
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