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- W4280490059 abstract "Abstract Specification of the germ layers by Nodal signaling has long been regarded as an archetype of how graded morphogens induce different cell fates. However, this deterministic model cannot explain why only a subset of cells at the margin of the early zebrafish embryo adopt the endodermal fate, while their immediate neighbours, experiencing similar signaling profiles, become mesoderm. Combining pharmacology, quantitative imaging and single cell transcriptomics, we demonstrate that sustained Nodal signaling establishes a bipotential progenitor state where cells initially fated to become mesoderm can switch to an endodermal fate. Switching is a random event, the likelihood of which is modulated by Fgf signaling. This inherently imprecise mechanism nevertheless leads to robust endoderm formation because of buffering at later stages. Thus, in contrast to previous deterministic models of morphogen action, Nodal establishes a temporal window when cells are competent to undergo a stochastic cell fate switch, rather than determining fate itself." @default.
- W4280490059 created "2022-05-22" @default.
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- W4280490059 date "2022-04-22" @default.
- W4280490059 modified "2023-09-29" @default.
- W4280490059 title "Nodal signaling establishes a competency window for stochastic cell fate switching" @default.
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- W4280490059 doi "https://doi.org/10.1101/2022.04.22.489156" @default.
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