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- W4280490287 abstract "Recognition of a stop codon by translation machinery as a sense codon results in translational readthrough instead of termination. This recoding process, termed stop codon readthrough (SCR) or translational readthrough, is found in all domains of life including mammals. The context of the stop codon, local mRNA topology, and molecules that interact with the mRNA region downstream of the stop codon determine SCR. The products of SCR can have localization, stability, and function different from those of the canonical isoforms. In this review, we discuss how recent technological and computational advances have increased our understanding of the SCR process in the mammalian system. Based on the known molecular events that occur during SCR of multiple mRNAs, we propose transient molecular roadblocks on an mRNA downstream of the stop codon as a possible mechanism for the induction of SCR. We argue, with examples, that the insights gained from the natural SCR events can guide us to develop novel strategies for the treatment of diseases caused by premature stop codons. This article is categorized under: Translation > Regulation." @default.
- W4280490287 created "2022-05-22" @default.
- W4280490287 creator A5031377330 @default.
- W4280490287 creator A5056835086 @default.
- W4280490287 creator A5064150584 @default.
- W4280490287 creator A5064958560 @default.
- W4280490287 date "2022-05-15" @default.
- W4280490287 modified "2023-10-18" @default.
- W4280490287 title "Mammalian proteome expansion by stop codon readthrough" @default.
- W4280490287 cites W1021008049 @default.
- W4280490287 cites W1195318580 @default.
- W4280490287 cites W1559739851 @default.
- W4280490287 cites W1965482690 @default.
- W4280490287 cites W1966484194 @default.
- W4280490287 cites W1972855007 @default.
- W4280490287 cites W1976221241 @default.
- W4280490287 cites W1988397255 @default.
- W4280490287 cites W1993655267 @default.
- W4280490287 cites W1994398448 @default.
- W4280490287 cites W1995352318 @default.
- W4280490287 cites W1997459647 @default.
- W4280490287 cites W2000694605 @default.
- W4280490287 cites W2003521251 @default.
- W4280490287 cites W2006585968 @default.
- W4280490287 cites W2009957038 @default.
- W4280490287 cites W2010461414 @default.
- W4280490287 cites W2012324453 @default.
- W4280490287 cites W2014746879 @default.
- W4280490287 cites W2025792957 @default.
- W4280490287 cites W2026393494 @default.
- W4280490287 cites W2026525219 @default.
- W4280490287 cites W2027255663 @default.
- W4280490287 cites W2031335201 @default.
- W4280490287 cites W2036163697 @default.
- W4280490287 cites W2044609070 @default.
- W4280490287 cites W2045107986 @default.
- W4280490287 cites W2049734985 @default.
- W4280490287 cites W2051524933 @default.
- W4280490287 cites W2052326665 @default.
- W4280490287 cites W2052812651 @default.
- W4280490287 cites W2058949200 @default.
- W4280490287 cites W2059029000 @default.
- W4280490287 cites W2059921194 @default.
- W4280490287 cites W2064073861 @default.
- W4280490287 cites W2065437076 @default.
- W4280490287 cites W2066841033 @default.
- W4280490287 cites W2067817921 @default.
- W4280490287 cites W2071226544 @default.
- W4280490287 cites W2071849521 @default.
- W4280490287 cites W2072554320 @default.
- W4280490287 cites W2074477570 @default.
- W4280490287 cites W2075383643 @default.
- W4280490287 cites W2079517684 @default.
- W4280490287 cites W2084297010 @default.
- W4280490287 cites W2084345535 @default.
- W4280490287 cites W2084360037 @default.
- W4280490287 cites W2084530852 @default.
- W4280490287 cites W2085811948 @default.
- W4280490287 cites W2088501568 @default.
- W4280490287 cites W2088873069 @default.
- W4280490287 cites W2089536721 @default.
- W4280490287 cites W2099502558 @default.
- W4280490287 cites W2099837980 @default.
- W4280490287 cites W2100252315 @default.
- W4280490287 cites W2102178107 @default.
- W4280490287 cites W2106252390 @default.
- W4280490287 cites W2109602972 @default.
- W4280490287 cites W2112096782 @default.
- W4280490287 cites W2115226207 @default.
- W4280490287 cites W2116528895 @default.
- W4280490287 cites W2117472380 @default.
- W4280490287 cites W2119086628 @default.
- W4280490287 cites W2121030623 @default.
- W4280490287 cites W2122967691 @default.
- W4280490287 cites W2123767456 @default.
- W4280490287 cites W2125712244 @default.
- W4280490287 cites W2136211980 @default.
- W4280490287 cites W2138022079 @default.
- W4280490287 cites W2141838466 @default.
- W4280490287 cites W2145473270 @default.
- W4280490287 cites W2153369718 @default.
- W4280490287 cites W2155346577 @default.
- W4280490287 cites W2158010208 @default.
- W4280490287 cites W2159006092 @default.
- W4280490287 cites W2159814661 @default.
- W4280490287 cites W2160400422 @default.
- W4280490287 cites W2165566599 @default.
- W4280490287 cites W2170566884 @default.
- W4280490287 cites W2171169461 @default.
- W4280490287 cites W2171875574 @default.
- W4280490287 cites W2220472391 @default.
- W4280490287 cites W2274319005 @default.
- W4280490287 cites W2298792983 @default.
- W4280490287 cites W2418956892 @default.
- W4280490287 cites W2466636931 @default.
- W4280490287 cites W2500220643 @default.
- W4280490287 cites W2512313819 @default.
- W4280490287 cites W2523639490 @default.
- W4280490287 cites W2528751872 @default.
- W4280490287 cites W2549271860 @default.