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- W4280490360 abstract "Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, despite declining mortality rates due to improved treatment. Preventive strategies could be essential to reduce CVD burden, but will require a better understanding of the pathophysiological mechanisms underlying CVD development. Studying the genetic architecture of CVD and its risk factors might aid in this endeavor.Genome-wide association studies can increase our understanding of the underlying biological architecture of CVD and its risk factors by identifying associated genetic variants. These genetic variants can then be used to obtain generally unconfounded genetic associations between a risk factor and CVD.This thesis identifies novel genetic variants associated with prevalent lifestyle behaviors and several heart rate traits. We provide evidence that television watching might causally increase risk of coronary artery disease development. A genetic association between caffeine intake and CVD was not established. We find that heart rate at rest, its variability, its increase during exercise, and its recovery after exercise, are not likely on the causal pathway to mortality. We do find that higher genetically predicted resting heart rate decreases risk of atrial fibrillation, ischemic stroke and cardio-embolic stroke. The genetic association of resting heart rate with ischemic and cardio-embolic stroke is unlikely caused by resting heart rate itself, but is probably driven by the effect of resting heart rate associated variants on respectively pulse pressure and atrial fibrillation. The findings described in this thesis increase our insights in the pathophysiological mechanisms leading to CVD and may improve risk stratification and prevention strategies." @default.
- W4280490360 created "2022-05-22" @default.
- W4280490360 creator A5000410021 @default.
- W4280490360 date "2022-05-13" @default.
- W4280490360 modified "2023-09-28" @default.
- W4280490360 title "Lifestyle, heart rate and cardiovascular diseaseLifestyle, heart rate and cardiovascular disease" @default.
- W4280490360 doi "https://doi.org/10.33612/diss.215908343" @default.
- W4280490360 hasPublicationYear "2022" @default.
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