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- W4280490370 abstract "Liquid-liquid phase separation (LLPS) has received significant attention in recent biological studies. It refers to a phenomenon that biomolecule exceeds the solubility, condensates and separates itself from solution in liquid like droplets formation. Our understanding of it has also changed from memebraneless organelles to compartmentalization, muti-functional crucibles, and reaction regulators. Although this phenomenon has been employed for a variety of biological processes, recent studies mainly focus on its physiological significance, and the comprehensive research of the underlying physical mechanism is limited. The characteristics of side chains of amino acids and the interaction tendency of proteins function importantly in regulating LLPS thus should be pay more attention on. In addition, the importance of post-translational modifications (PTMs) has been underestimated, despite their abundance and crucial functions in maintaining the electrostatic balance. In this review, we first introduce the driving forces and protein secondary structures involved in LLPS and their different physical functions in cell life processes. Subsequently, we summarize the existing reports on PTM regulation related to LLPS and analyze the underlying basic principles, hoping to find some common relations between LLPS and PTM. Finally, we speculate several unreported PTMs that may have a significant impact on phase separation basing on the findings." @default.
- W4280490370 created "2022-05-22" @default.
- W4280490370 creator A5038187224 @default.
- W4280490370 creator A5044029807 @default.
- W4280490370 creator A5057762106 @default.
- W4280490370 creator A5058424494 @default.
- W4280490370 creator A5059065464 @default.
- W4280490370 creator A5067115806 @default.
- W4280490370 creator A5067410324 @default.
- W4280490370 date "2022-05-11" @default.
- W4280490370 modified "2023-10-15" @default.
- W4280490370 title "Post-translational modifications in liquid-liquid phase separation: a comprehensive review" @default.
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