FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280490778> ?p ?o ?g. }

• W4280490778 endingPage "154173" @default.
• W4280490778 startingPage "154173" @default.
• W4280490778 abstract "Cholestasis is a clinical syndrome with high incidence and few effective treatments. Oleanolic acid (OA) is a triterpenoid compound with anti-cholestatic effects. Studies using bile duct ligation or lithocholic acid modeling have shown that the alleviating effect of OA on cholerosis is related to the regulation of nuclear factor erythroid 2 related factor (Nrf2) or farnesoid X receptor (Fxr).This study aims to investigate the underlying mechanism of OA against alpha-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury based on Nrf2 and Fxr dual signaling pathways.The ANIT-induced rats model was used with or without OA treatment. Serum biochemical indexes, liver histopathological changes and glutathione level were examined. Bile acids (BAs) targeted metabolomics based on UHPLC-MS/MS were performed. siRNA, RT-qPCR and western blot analysis were used to prove the role of Fxr and Nrf2 pathway in OA's anti-cholestatic liver injury in vivo and in vitro.OA significantly alleviated ANIT-induced liver injury in rats, reduced primary bile acids, accelerated metabolism of BAs and reduced the intrahepatic accumulation of BAs. The expressions of bile salt export pump (Bsep), Na+-taurocholic cotransport polypeptide (Ntcp), UDP-glucuronyl transferase 1a1 (Ugt1a1) and Fxr in rat liver were markedly up-regulated, the activation of Nrf2 was promoted, and the expression of cholesterol 7α-hydroxylase (Cyp7a1) was decreased after OA treatment. Moreover, Fxr or Nrf2 silencing attenuated the regulation of OA on BAs homeostasis related transporters and enzymes in rat primary hepatocytes.OA may regulate BAs-related transporters and metabolic enzymes by activating Fxr and Nrf2 pathways, thus alleviating the cholestatic liver injury induced by ANIT." @default.
• W4280490778 created "2022-05-22" @default.
• W4280490778 creator A5002262984 @default.
• W4280490778 creator A5008264216 @default.
• W4280490778 creator A5052890099 @default.
• W4280490778 creator A5055617627 @default.
• W4280490778 creator A5060006875 @default.
• W4280490778 creator A5073902371 @default.
• W4280490778 date "2022-07-01" @default.
• W4280490778 modified "2023-10-18" @default.
• W4280490778 title "Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis" @default.
• W4280490778 cites W1119423221 @default.
• W4280490778 cites W1971342792 @default.
• W4280490778 cites W2045759446 @default.
• W4280490778 cites W2078810890 @default.
• W4280490778 cites W2136962885 @default.
• W4280490778 cites W2155864743 @default.
• W4280490778 cites W2176388629 @default.
• W4280490778 cites W2565416332 @default.
• W4280490778 cites W2572174115 @default.
• W4280490778 cites W2592482187 @default.
• W4280490778 cites W2728817097 @default.
• W4280490778 cites W2734346062 @default.
• W4280490778 cites W2758914933 @default.
• W4280490778 cites W2761145411 @default.
• W4280490778 cites W2761773602 @default.
• W4280490778 cites W2775591507 @default.
• W4280490778 cites W2778390291 @default.
• W4280490778 cites W2797710096 @default.
• W4280490778 cites W2808397477 @default.
• W4280490778 cites W2885452066 @default.
• W4280490778 cites W2893514707 @default.
• W4280490778 cites W2906137376 @default.
• W4280490778 cites W2917456230 @default.
• W4280490778 cites W2946806894 @default.
• W4280490778 cites W2978782074 @default.
• W4280490778 cites W2979675761 @default.
• W4280490778 cites W2995732359 @default.
• W4280490778 cites W3009852690 @default.
• W4280490778 cites W3095553881 @default.
• W4280490778 cites W3111303411 @default.
• W4280490778 cites W3119042530 @default.
• W4280490778 cites W3120328288 @default.
• W4280490778 cites W3165157607 @default.
• W4280490778 cites W3172816816 @default.
• W4280490778 cites W3179532037 @default.
• W4280490778 cites W3184951153 @default.
• W4280490778 cites W4243722521 @default.
• W4280490778 doi "https://doi.org/10.1016/j.phymed.2022.154173" @default.
• W4280490778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35605478" @default.
• W4280490778 hasPublicationYear "2022" @default.
• W4280490778 type Work @default.
• W4280490778 citedByCount "8" @default.
• W4280490778 countsByYear W42804907782022 @default.
• W4280490778 countsByYear W42804907782023 @default.
• W4280490778 crossrefType "journal-article" @default.
• W4280490778 hasAuthorship W4280490778A5002262984 @default.
• W4280490778 hasAuthorship W4280490778A5008264216 @default.
• W4280490778 hasAuthorship W4280490778A5052890099 @default.
• W4280490778 hasAuthorship W4280490778A5055617627 @default.
• W4280490778 hasAuthorship W4280490778A5060006875 @default.
• W4280490778 hasAuthorship W4280490778A5073902371 @default.
• W4280490778 hasConcept C10213722 @default.
• W4280490778 hasConcept C104317684 @default.
• W4280490778 hasConcept C123584848 @default.
• W4280490778 hasConcept C126322002 @default.
• W4280490778 hasConcept C134018914 @default.
• W4280490778 hasConcept C142724271 @default.
• W4280490778 hasConcept C149011108 @default.
• W4280490778 hasConcept C183481951 @default.
• W4280490778 hasConcept C185592680 @default.
• W4280490778 hasConcept C203862802 @default.
• W4280490778 hasConcept C204787440 @default.
• W4280490778 hasConcept C2776637226 @default.
• W4280490778 hasConcept C2778593092 @default.
• W4280490778 hasConcept C2778858181 @default.
• W4280490778 hasConcept C2779399885 @default.
• W4280490778 hasConcept C2780420665 @default.
• W4280490778 hasConcept C2780480987 @default.
• W4280490778 hasConcept C2910800957 @default.
• W4280490778 hasConcept C39321552 @default.
• W4280490778 hasConcept C55493867 @default.
• W4280490778 hasConcept C63932345 @default.
• W4280490778 hasConcept C71924100 @default.
• W4280490778 hasConcept C86339819 @default.
• W4280490778 hasConcept C89673097 @default.
• W4280490778 hasConcept C98274493 @default.
• W4280490778 hasConceptScore W4280490778C10213722 @default.
• W4280490778 hasConceptScore W4280490778C104317684 @default.
• W4280490778 hasConceptScore W4280490778C123584848 @default.
• W4280490778 hasConceptScore W4280490778C126322002 @default.
• W4280490778 hasConceptScore W4280490778C134018914 @default.
• W4280490778 hasConceptScore W4280490778C142724271 @default.
• W4280490778 hasConceptScore W4280490778C149011108 @default.
• W4280490778 hasConceptScore W4280490778C183481951 @default.
• W4280490778 hasConceptScore W4280490778C185592680 @default.
• W4280490778 hasConceptScore W4280490778C203862802 @default.
• W4280490778 hasConceptScore W4280490778C204787440 @default.

• next