Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280490939> ?p ?o ?g. }
- W4280490939 abstract "Abstract Background Neutralizing antibodies are approved drugs to treat coronavirus disease-2019 (COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants may reduce the antibody neutralizing activity. New monoclonal antibodies (mAbs) and antibody remolding strategies are recalled in the battle with COVID-19 epidemic. Results We identified multiple mAbs from antibody phage display library made from COVID-19 patients and further characterized the R3P1-E4 clone, which effectively suppressed SARS-CoV-2 infection and rescued the lethal phenotype in mice infected with SARS-CoV-2. Crystal structural analysis not only explained why R3P1-E4 had selectively reduced binding and neutralizing activity to SARS-CoV-2 variants carrying K417 mutations, but also allowed us to engineer mutant antibodies with improved neutralizing activity against these variants. Thus, we screened out R3P1-E4 mAb which inhibits SARS-CoV-2 and related mutations in vitro and in vivo. Antibody engineering improved neutralizing activity of R3P1-E4 against K417 mutations. Conclusion Our studies have outlined a strategy to identify and engineer neutralizing antibodies against SARS-CoV-2 variants." @default.
- W4280490939 created "2022-05-22" @default.
- W4280490939 creator A5002701262 @default.
- W4280490939 creator A5005132315 @default.
- W4280490939 creator A5009516775 @default.
- W4280490939 creator A5014661038 @default.
- W4280490939 creator A5023625601 @default.
- W4280490939 creator A5030126374 @default.
- W4280490939 creator A5038141763 @default.
- W4280490939 creator A5038486259 @default.
- W4280490939 creator A5043396671 @default.
- W4280490939 creator A5045938742 @default.
- W4280490939 creator A5056028884 @default.
- W4280490939 creator A5062907814 @default.
- W4280490939 creator A5068252474 @default.
- W4280490939 creator A5075210385 @default.
- W4280490939 creator A5081745474 @default.
- W4280490939 creator A5088124900 @default.
- W4280490939 date "2022-05-17" @default.
- W4280490939 modified "2023-10-18" @default.
- W4280490939 title "Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants" @default.
- W4280490939 cites W2103503400 @default.
- W4280490939 cites W2124026197 @default.
- W4280490939 cites W2152107372 @default.
- W4280490939 cites W2163341755 @default.
- W4280490939 cites W2180229411 @default.
- W4280490939 cites W2940763506 @default.
- W4280490939 cites W2979549406 @default.
- W4280490939 cites W3009912996 @default.
- W4280490939 cites W3014067025 @default.
- W4280490939 cites W3029682964 @default.
- W4280490939 cites W3034202401 @default.
- W4280490939 cites W3036386821 @default.
- W4280490939 cites W3036607916 @default.
- W4280490939 cites W3039901154 @default.
- W4280490939 cites W3041564586 @default.
- W4280490939 cites W3044660350 @default.
- W4280490939 cites W3046751266 @default.
- W4280490939 cites W3092403777 @default.
- W4280490939 cites W3096064145 @default.
- W4280490939 cites W3125266951 @default.
- W4280490939 cites W3127311730 @default.
- W4280490939 cites W3128186941 @default.
- W4280490939 cites W3133980772 @default.
- W4280490939 cites W3134363787 @default.
- W4280490939 cites W3134446480 @default.
- W4280490939 cites W3135409471 @default.
- W4280490939 cites W3135671690 @default.
- W4280490939 cites W3136616180 @default.
- W4280490939 cites W3138734145 @default.
- W4280490939 cites W3142246475 @default.
- W4280490939 cites W3147129678 @default.
- W4280490939 cites W3152684653 @default.
- W4280490939 cites W3156291144 @default.
- W4280490939 cites W3158223263 @default.
- W4280490939 cites W3158566032 @default.
- W4280490939 cites W3159224617 @default.
- W4280490939 cites W3160471157 @default.
- W4280490939 cites W3170097501 @default.
- W4280490939 cites W3170598451 @default.
- W4280490939 cites W3173716334 @default.
- W4280490939 cites W3183072827 @default.
- W4280490939 cites W3194514241 @default.
- W4280490939 cites W3200094766 @default.
- W4280490939 cites W3202702853 @default.
- W4280490939 doi "https://doi.org/10.1186/s13578-022-00794-7" @default.
- W4280490939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35581593" @default.
- W4280490939 hasPublicationYear "2022" @default.
- W4280490939 type Work @default.
- W4280490939 citedByCount "3" @default.
- W4280490939 countsByYear W42804909392023 @default.
- W4280490939 crossrefType "journal-article" @default.
- W4280490939 hasAuthorship W4280490939A5002701262 @default.
- W4280490939 hasAuthorship W4280490939A5005132315 @default.
- W4280490939 hasAuthorship W4280490939A5009516775 @default.
- W4280490939 hasAuthorship W4280490939A5014661038 @default.
- W4280490939 hasAuthorship W4280490939A5023625601 @default.
- W4280490939 hasAuthorship W4280490939A5030126374 @default.
- W4280490939 hasAuthorship W4280490939A5038141763 @default.
- W4280490939 hasAuthorship W4280490939A5038486259 @default.
- W4280490939 hasAuthorship W4280490939A5043396671 @default.
- W4280490939 hasAuthorship W4280490939A5045938742 @default.
- W4280490939 hasAuthorship W4280490939A5056028884 @default.
- W4280490939 hasAuthorship W4280490939A5062907814 @default.
- W4280490939 hasAuthorship W4280490939A5068252474 @default.
- W4280490939 hasAuthorship W4280490939A5075210385 @default.
- W4280490939 hasAuthorship W4280490939A5081745474 @default.
- W4280490939 hasAuthorship W4280490939A5088124900 @default.
- W4280490939 hasBestOaLocation W42804909391 @default.
- W4280490939 hasConcept C104317684 @default.
- W4280490939 hasConcept C14086860 @default.
- W4280490939 hasConcept C142724271 @default.
- W4280490939 hasConcept C143065580 @default.
- W4280490939 hasConcept C159047783 @default.
- W4280490939 hasConcept C159654299 @default.
- W4280490939 hasConcept C186268636 @default.
- W4280490939 hasConcept C203014093 @default.
- W4280490939 hasConcept C2522874641 @default.
- W4280490939 hasConcept C2777648638 @default.
- W4280490939 hasConcept C2779134260 @default.