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• W4280490976 abstract "The increase in blood glucose causes a myriad of pathways and molecular components to malfunction, leading to diabetes. Diabetes affects each organ differently by activating distinct pathways. It has an impact on the liver, pancreas, kidney (nephropathy), eyes (retinopathy), and nervous system (neuropathy). Understanding the effects of diabetes on each organ is the first step in developing a sustained treatment for the disease. Among the many cellular molecules impacted by diabetes is Ca2+/calmodulin-dependent protein kinase II (CaMKII), a complex Ca2+/calmodulin-activated serine/threonine-protein kinase. When intracellular [Ca2+] rises, it binds to calmodulin (CaM) to produce Ca2+/CaM, which activates CaMKIIs. This factor is involved in the pancreas, liver, heart, muscles, and various organs. Thus, Understanding CaMKII action in each organ is critical for gaining a complete picture of diabetic complications. Therefore, this review covers CaMKII's functions in many organs and how it affects and has been affected by diabetes." @default.
• W4280490976 created "2022-05-22" @default.
• W4280490976 creator A5012919791 @default.
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• W4280490976 date "2022-05-12" @default.
• W4280490976 modified "2023-09-25" @default.
• W4280490976 title "The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression" @default.
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• W4280490976 doi "https://doi.org/10.1007/s12079-022-00680-4" @default.
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