FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280490980> ?p ?o ?g. }

• W4280490980 endingPage "69007" @default.
• W4280490980 startingPage "68990" @default.
• W4280490980 abstract "Diabetes mellitus (DM) is a metabolic disorder that causes severe complications in several tissues due to redox imbalances, which in turn cause defective angiogenesis in response to ischemia and activate a number of proinflammatory pathways. Our study aimed to investigate the effect of bee gomogenat (BG) dietary supplementation on the architecture of immune organs in a streptozotocin (STZ)-induced type 1 diabetes (T1D) mouse model. Three animal groups were used: the control non-diabetic, diabetic, and BG-treated diabetic groups. STZ-induced diabetes was associated with increased levels of blood glucose, ROS, and IL-6 and decreased levels of IL-2, IL-7, IL-4, and GSH. Moreover, diabetic mice showed alterations in the expression of autophagy markers (LC3, Beclin-1, and P62) and apoptosis markers (Bcl-2 and Bax) in the thymus, spleen, and lymph nodes. Most importantly, the phosphorylation level of AKT (a promoter of cell survival) was significantly decreased, but the expression levels of MCP-1 and HSP-70 (markers of inflammation) were significantly increased in the spleen and lymph nodes in diabetic mice compared to control animals. Interestingly, oral supplementation with BG restored the levels of blood glucose, ROS, IL-6, IL-2, IL-4, IL-7, and GSH in diabetic mice. Treatment with BG significantly abrogated apoptosis and autophagy in lymphoid organs in diabetic mice by restoring the expression levels of LC3, Beclin-1, P62, Bcl-2, and Bax; decreasing inflammatory signals by downregulating the expression of MCP-1 and HSP-70; and promoting cell survival by enhancing the phosphorylation of AKT. Our data were the first to reveal the therapeutic potential of BG on the architecture of lymphoid organs and enhancing the immune system during T1D." @default.
• W4280490980 created "2022-05-22" @default.
• W4280490980 creator A5036052092 @default.
• W4280490980 creator A5049609475 @default.
• W4280490980 creator A5049742977 @default.
• W4280490980 creator A5053483364 @default.
• W4280490980 creator A5074867644 @default.
• W4280490980 date "2022-05-13" @default.
• W4280490980 modified "2023-09-25" @default.
• W4280490980 title "Bee gomogenat rescues lymphoid organs from degeneration by regulating the crosstalk between apoptosis and autophagy in streptozotocin-induced diabetic mice" @default.
• W4280490980 cites W1576754339 @default.
• W4280490980 cites W1728276264 @default.
• W4280490980 cites W1930477314 @default.
• W4280490980 cites W1964032090 @default.
• W4280490980 cites W1973821691 @default.
• W4280490980 cites W1974309729 @default.
• W4280490980 cites W1978138123 @default.
• W4280490980 cites W1978917500 @default.
• W4280490980 cites W1979281993 @default.
• W4280490980 cites W1995311442 @default.
• W4280490980 cites W2001755595 @default.
• W4280490980 cites W2003059814 @default.
• W4280490980 cites W2004664005 @default.
• W4280490980 cites W2008869879 @default.
• W4280490980 cites W2009616122 @default.
• W4280490980 cites W2014477844 @default.
• W4280490980 cites W2016368302 @default.
• W4280490980 cites W2023379699 @default.
• W4280490980 cites W2032688774 @default.
• W4280490980 cites W2036411709 @default.
• W4280490980 cites W2046208657 @default.
• W4280490980 cites W2054129051 @default.
• W4280490980 cites W2054203136 @default.
• W4280490980 cites W2059738518 @default.
• W4280490980 cites W2062389441 @default.
• W4280490980 cites W2065406318 @default.
• W4280490980 cites W2065829421 @default.
• W4280490980 cites W2067503419 @default.
• W4280490980 cites W2067647130 @default.
• W4280490980 cites W2071255369 @default.
• W4280490980 cites W2078711922 @default.
• W4280490980 cites W2089728480 @default.
• W4280490980 cites W2093403667 @default.
• W4280490980 cites W2109164958 @default.
• W4280490980 cites W2117388954 @default.
• W4280490980 cites W2118742454 @default.
• W4280490980 cites W2122659224 @default.
• W4280490980 cites W2129387684 @default.
• W4280490980 cites W2134843064 @default.
• W4280490980 cites W2138249160 @default.
• W4280490980 cites W2139628557 @default.
• W4280490980 cites W2140057116 @default.
• W4280490980 cites W2145434871 @default.
• W4280490980 cites W2148658155 @default.
• W4280490980 cites W2159372512 @default.
• W4280490980 cites W2260503538 @default.
• W4280490980 cites W2290984819 @default.
• W4280490980 cites W2461997261 @default.
• W4280490980 cites W2484914234 @default.
• W4280490980 cites W2530218617 @default.
• W4280490980 cites W2563195238 @default.
• W4280490980 cites W2581762344 @default.
• W4280490980 cites W2740695644 @default.
• W4280490980 cites W2766054477 @default.
• W4280490980 cites W2767015190 @default.
• W4280490980 cites W2768918778 @default.
• W4280490980 cites W2769622412 @default.
• W4280490980 cites W2775661287 @default.
• W4280490980 cites W2789828321 @default.
• W4280490980 cites W2792517082 @default.
• W4280490980 cites W2810405407 @default.
• W4280490980 cites W2886442927 @default.
• W4280490980 cites W2893586031 @default.
• W4280490980 cites W2897666749 @default.
• W4280490980 cites W2922252193 @default.
• W4280490980 cites W3005091804 @default.
• W4280490980 cites W3044344005 @default.
• W4280490980 cites W3108265502 @default.
• W4280490980 cites W3123223563 @default.
• W4280490980 cites W3126193415 @default.
• W4280490980 cites W3128039453 @default.
• W4280490980 cites W3166893944 @default.
• W4280490980 cites W3194100301 @default.
• W4280490980 cites W3201592012 @default.
• W4280490980 cites W3215332542 @default.
• W4280490980 cites W4200540688 @default.
• W4280490980 cites W4211053686 @default.
• W4280490980 doi "https://doi.org/10.1007/s11356-022-20457-x" @default.
• W4280490980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35554836" @default.
• W4280490980 hasPublicationYear "2022" @default.
• W4280490980 type Work @default.
• W4280490980 citedByCount "0" @default.
• W4280490980 crossrefType "journal-article" @default.
• W4280490980 hasAuthorship W4280490980A5036052092 @default.
• W4280490980 hasAuthorship W4280490980A5049609475 @default.
• W4280490980 hasAuthorship W4280490980A5049742977 @default.
• W4280490980 hasAuthorship W4280490980A5053483364 @default.
• W4280490980 hasAuthorship W4280490980A5074867644 @default.

• next