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- W4280490985 abstract "Abstract Subarachnoid hemorrhage being the rupture of intracranial aneurysm (IA) as a major cause has a high mortality rate. It is thus mandatory for social health to clarify mechanisms regulating rupture of IAs and to develop a novel therapeutic strategy. Recently, the formation of vasa vasorum in lesions presumably for inflammatory cells to infiltrate in lesions has been clarified as a potential histopathological alternation leading to rupture. We clarified the origin of this structure as arteries on brain surface and the presence of hypoxic microenvironment mainly at the adventitia of intracranial arteries where IA is induced. The production of vascular endothelial growth factor (VEGF) not only from cultured macrophages in such a hypoxic condition but also at rupture-prone IA lesions induced in a rat model was clarified. We further found the accumulation of VEGF in human unruptured IA lesions, supporting the production of VEGF in situ . Finally, we confirmed the VEGF-dependent migration of neovessels into subarachnoid space from arteries on brain surface. Because of the lack of vasa vasorum and being surrounded by cerebrospinal fluid space, the formation of hypoxic microenvironment becomes a character of intracranial arteries and inflammatory responses could further facilitate such a condition. Additionally, the attachment of IA to brain surface might be an important factor for the migration of vasa vasorum from arteries on brain surface. The findings have revealed the potential role of hypoxic microenvironment as a potential machinery triggering rupture of IAs via providing root for inflammatory cells to infiltrate into lesions and exacerbate inflammation." @default.
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- W4280490985 date "2022-05-11" @default.
- W4280490985 modified "2023-09-26" @default.
- W4280490985 title "Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm" @default.
- W4280490985 doi "https://doi.org/10.21203/rs.3.rs-1520573/v2" @default.
- W4280490985 hasPublicationYear "2022" @default.
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