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- W4280491058 endingPage "492" @default.
- W4280491058 startingPage "483" @default.
- W4280491058 abstract "A pair of extensively modified microtubules form the central apparatus (CA) of the axoneme of most motile cilia, where they regulate ciliary motility. The external surfaces of both CA microtubules are patterned asymmetrically with large protein complexes that repeat every 16 or 32 nm. The composition of these projections and the mechanisms that establish asymmetry and longitudinal periodicity are unknown. Here, by determining cryo-EM structures of the CA microtubules, we identify 48 different CA-associated proteins, which in turn reveal mechanisms for asymmetric and periodic protein binding to microtubules. We identify arc-MIPs, a novel class of microtubule inner protein, that bind laterally across protofilaments and remodel tubulin structure and lattice contacts. The binding mechanisms utilized by CA proteins may be generalizable to other microtubule-associated proteins. These structures establish a foundation to elucidate the contributions of individual CA proteins to ciliary motility and ciliopathies." @default.
- W4280491058 created "2022-05-22" @default.
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- W4280491058 creator A5080795341 @default.
- W4280491058 creator A5087704922 @default.
- W4280491058 date "2022-05-01" @default.
- W4280491058 modified "2023-10-05" @default.
- W4280491058 title "Ciliary central apparatus structure reveals mechanisms of microtubule patterning" @default.
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- W4280491058 doi "https://doi.org/10.1038/s41594-022-00770-2" @default.
- W4280491058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35578023" @default.
- W4280491058 hasPublicationYear "2022" @default.
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