Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280491510> ?p ?o ?g. }
- W4280491510 endingPage "e0010386" @default.
- W4280491510 startingPage "e0010386" @default.
- W4280491510 abstract "Approximately 6 million people worldwide are affected by Chagas disease, with many in the chronic phase of the disease (CCD). It is crucial to evaluate the effectiveness of benznidazole for CCD treatment.We updated a meta-analysis published in 2009 up to February 2021, including controlled trials (RCT) and prospective observational studies (OBS) that compared benznidazole vs placebo/no-treatment (P/nT). Main outcomes evaluated were clinical progression (CP) and seroreversion with subgroup analysis performed according to study design and participants' age. Parasitological response and safety were also described. We identified 879 articles and selected nine for inclusion (corresponding to eight studies). After adding the nine articles from the previous meta-analysis, 17 studies were analyzed corresponding to 6640 patients. The odds ratio (OR) for seroreversion in children treated with benznidazole vs P/nT was 38.3 (95%CI: 10.7-137) and 34.9 (95%CI: 1.96-624.09) in RCT and OBS, respectively. In adults the OR for seroreversion in OBS was 17.1 (95%CI: 2.3-129.1). CP was only evaluated in adults, where benznidazole did not demonstrate a beneficial effect: OR 0.93 (95%CI: 0.8-1.1) and OR 0.49 (95%CI:0.2-1.2) for RCT and OBS, respectively. Most outcomes were deemed to have a low level of certainty, except for the beneficial effect in children and the low efficacy in adults (moderate certainty).Benznidazole should be recommended for CCD in children, though this is only based on serological response and a moderate grade of evidence, while in adults benznidazole efficacy remains uncertain. More data on clinical efficacy of benznidazole in CCD is needed in both children and adults." @default.
- W4280491510 created "2022-05-22" @default.
- W4280491510 creator A5007428782 @default.
- W4280491510 creator A5033769106 @default.
- W4280491510 creator A5049696539 @default.
- W4280491510 creator A5062724332 @default.
- W4280491510 creator A5077282917 @default.
- W4280491510 creator A5086877004 @default.
- W4280491510 creator A5091220440 @default.
- W4280491510 date "2022-05-16" @default.
- W4280491510 modified "2023-10-16" @default.
- W4280491510 title "Use of benznidazole to treat chronic Chagas disease: An updated systematic review with a meta-analysis" @default.
- W4280491510 cites W1254691581 @default.
- W4280491510 cites W170818818 @default.
- W4280491510 cites W1972043575 @default.
- W4280491510 cites W1977181707 @default.
- W4280491510 cites W2003421329 @default.
- W4280491510 cites W2009912761 @default.
- W4280491510 cites W2016047547 @default.
- W4280491510 cites W2035437114 @default.
- W4280491510 cites W2057334484 @default.
- W4280491510 cites W2063503143 @default.
- W4280491510 cites W2071316624 @default.
- W4280491510 cites W2074713162 @default.
- W4280491510 cites W2078233229 @default.
- W4280491510 cites W2079756317 @default.
- W4280491510 cites W2087670793 @default.
- W4280491510 cites W2092388750 @default.
- W4280491510 cites W2097558240 @default.
- W4280491510 cites W2098923148 @default.
- W4280491510 cites W2102096286 @default.
- W4280491510 cites W2113628732 @default.
- W4280491510 cites W2117846137 @default.
- W4280491510 cites W2119509691 @default.
- W4280491510 cites W2136403658 @default.
- W4280491510 cites W2139287872 @default.
- W4280491510 cites W2139717699 @default.
- W4280491510 cites W2151383102 @default.
- W4280491510 cites W2152153749 @default.
- W4280491510 cites W2156224401 @default.
- W4280491510 cites W2162778646 @default.
- W4280491510 cites W2164957182 @default.
- W4280491510 cites W2171111655 @default.
- W4280491510 cites W2176496563 @default.
- W4280491510 cites W2239631772 @default.
- W4280491510 cites W2322471444 @default.
- W4280491510 cites W2333627902 @default.
- W4280491510 cites W2519316739 @default.
- W4280491510 cites W2556635462 @default.
- W4280491510 cites W2560613109 @default.
- W4280491510 cites W2588681363 @default.
- W4280491510 cites W2589928324 @default.
- W4280491510 cites W2784228551 @default.
- W4280491510 cites W2808145743 @default.
- W4280491510 cites W2884698878 @default.
- W4280491510 cites W2912197610 @default.
- W4280491510 cites W2954792327 @default.
- W4280491510 cites W2984692023 @default.
- W4280491510 cites W3030996715 @default.
- W4280491510 cites W3035872412 @default.
- W4280491510 cites W3071395538 @default.
- W4280491510 cites W3092433286 @default.
- W4280491510 cites W3146533948 @default.
- W4280491510 cites W3148962211 @default.
- W4280491510 cites W4210992500 @default.
- W4280491510 cites W4299960106 @default.
- W4280491510 cites W67775154 @default.
- W4280491510 doi "https://doi.org/10.1371/journal.pntd.0010386" @default.
- W4280491510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35576215" @default.
- W4280491510 hasPublicationYear "2022" @default.
- W4280491510 type Work @default.
- W4280491510 citedByCount "9" @default.
- W4280491510 countsByYear W42804915102023 @default.
- W4280491510 crossrefType "journal-article" @default.
- W4280491510 hasAuthorship W4280491510A5007428782 @default.
- W4280491510 hasAuthorship W4280491510A5033769106 @default.
- W4280491510 hasAuthorship W4280491510A5049696539 @default.
- W4280491510 hasAuthorship W4280491510A5062724332 @default.
- W4280491510 hasAuthorship W4280491510A5077282917 @default.
- W4280491510 hasAuthorship W4280491510A5086877004 @default.
- W4280491510 hasAuthorship W4280491510A5091220440 @default.
- W4280491510 hasBestOaLocation W42804915101 @default.
- W4280491510 hasConcept C126322002 @default.
- W4280491510 hasConcept C136764020 @default.
- W4280491510 hasConcept C142724271 @default.
- W4280491510 hasConcept C156957248 @default.
- W4280491510 hasConcept C168563851 @default.
- W4280491510 hasConcept C187960798 @default.
- W4280491510 hasConcept C204787440 @default.
- W4280491510 hasConcept C23131810 @default.
- W4280491510 hasConcept C27081682 @default.
- W4280491510 hasConcept C2776171842 @default.
- W4280491510 hasConcept C2777625466 @default.
- W4280491510 hasConcept C41008148 @default.
- W4280491510 hasConcept C535046627 @default.
- W4280491510 hasConcept C71924100 @default.
- W4280491510 hasConcept C71928629 @default.
- W4280491510 hasConcept C95190672 @default.