Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280491556> ?p ?o ?g. }
- W4280491556 endingPage "198816" @default.
- W4280491556 startingPage "198816" @default.
- W4280491556 abstract "Group B coxsackievirus is an enterovirus that can cause a variety of diseases, including myocarditis, aseptic meningitis, and hand, foot, and mouth disease. Currently, there is no effective antiviral drug against this virus. In this study, we used a cytopathic effect-based viral inhibition assay to screen an FDA-approved drug library and found that doxepin hydrochloride had potential antiviral activity. Doxepin hydrochloride exhibited strong antiviral activity against coxsackievirus B types 1-3 with a 50% inhibitory concentration of 10.12 ± 0.85 μM. Moreover, doxepin hydrochloride did not exert antiviral activity against other enteroviruses, including enterovirus A71 (subtypes BrCr/C4) and coxsackievirus A (subtypes 6/10/16). Furthermore, doxepin hydrochloride inhibited virus replication in the early stage of the infection cycle rather than affecting the entry or assembly process. In addition, a few mechanism-related pharmacophores were discovered through gene association network analysis. These findings identify a possible lead compound for treating coxsackievirus B infection and simultaneously offer valuable clues for drug repositioning." @default.
- W4280491556 created "2022-05-22" @default.
- W4280491556 creator A5014926502 @default.
- W4280491556 creator A5031796503 @default.
- W4280491556 creator A5034696342 @default.
- W4280491556 creator A5041593217 @default.
- W4280491556 creator A5064376545 @default.
- W4280491556 creator A5077224903 @default.
- W4280491556 creator A5081737278 @default.
- W4280491556 creator A5090473113 @default.
- W4280491556 date "2022-08-01" @default.
- W4280491556 modified "2023-10-18" @default.
- W4280491556 title "In-vitro antiviral activity of doxepin hydrochloride against group B coxsackievirus" @default.
- W4280491556 cites W1563843388 @default.
- W4280491556 cites W1940235456 @default.
- W4280491556 cites W1970172472 @default.
- W4280491556 cites W1975226337 @default.
- W4280491556 cites W1985230703 @default.
- W4280491556 cites W1993537053 @default.
- W4280491556 cites W2001799698 @default.
- W4280491556 cites W2014373102 @default.
- W4280491556 cites W2016948698 @default.
- W4280491556 cites W2017204494 @default.
- W4280491556 cites W2041523777 @default.
- W4280491556 cites W2052364955 @default.
- W4280491556 cites W2070719504 @default.
- W4280491556 cites W2071435808 @default.
- W4280491556 cites W2073064178 @default.
- W4280491556 cites W2087727258 @default.
- W4280491556 cites W2101033163 @default.
- W4280491556 cites W2121879352 @default.
- W4280491556 cites W2135250777 @default.
- W4280491556 cites W2145923858 @default.
- W4280491556 cites W2185438456 @default.
- W4280491556 cites W2314537502 @default.
- W4280491556 cites W2573672953 @default.
- W4280491556 cites W2593905261 @default.
- W4280491556 cites W2594752123 @default.
- W4280491556 cites W2603715071 @default.
- W4280491556 cites W2794200709 @default.
- W4280491556 cites W2895452070 @default.
- W4280491556 cites W2947905820 @default.
- W4280491556 cites W2964332577 @default.
- W4280491556 cites W2997552816 @default.
- W4280491556 cites W2998938603 @default.
- W4280491556 cites W3005670160 @default.
- W4280491556 cites W3008919653 @default.
- W4280491556 cites W3011233445 @default.
- W4280491556 cites W3015744875 @default.
- W4280491556 cites W3017154096 @default.
- W4280491556 cites W3112791591 @default.
- W4280491556 cites W3128583385 @default.
- W4280491556 cites W3167823963 @default.
- W4280491556 cites W3215296415 @default.
- W4280491556 cites W68197841 @default.
- W4280491556 cites W2526701398 @default.
- W4280491556 doi "https://doi.org/10.1016/j.virusres.2022.198816" @default.
- W4280491556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35598772" @default.
- W4280491556 hasPublicationYear "2022" @default.
- W4280491556 type Work @default.
- W4280491556 citedByCount "2" @default.
- W4280491556 countsByYear W42804915562023 @default.
- W4280491556 crossrefType "journal-article" @default.
- W4280491556 hasAuthorship W4280491556A5014926502 @default.
- W4280491556 hasAuthorship W4280491556A5031796503 @default.
- W4280491556 hasAuthorship W4280491556A5034696342 @default.
- W4280491556 hasAuthorship W4280491556A5041593217 @default.
- W4280491556 hasAuthorship W4280491556A5064376545 @default.
- W4280491556 hasAuthorship W4280491556A5077224903 @default.
- W4280491556 hasAuthorship W4280491556A5081737278 @default.
- W4280491556 hasAuthorship W4280491556A5090473113 @default.
- W4280491556 hasConcept C159047783 @default.
- W4280491556 hasConcept C2522874641 @default.
- W4280491556 hasConcept C2777747321 @default.
- W4280491556 hasConcept C2777888124 @default.
- W4280491556 hasConcept C2778889330 @default.
- W4280491556 hasConcept C2779120600 @default.
- W4280491556 hasConcept C2779756493 @default.
- W4280491556 hasConcept C2780035454 @default.
- W4280491556 hasConcept C86803240 @default.
- W4280491556 hasConcept C89423630 @default.
- W4280491556 hasConcept C98274493 @default.
- W4280491556 hasConceptScore W4280491556C159047783 @default.
- W4280491556 hasConceptScore W4280491556C2522874641 @default.
- W4280491556 hasConceptScore W4280491556C2777747321 @default.
- W4280491556 hasConceptScore W4280491556C2777888124 @default.
- W4280491556 hasConceptScore W4280491556C2778889330 @default.
- W4280491556 hasConceptScore W4280491556C2779120600 @default.
- W4280491556 hasConceptScore W4280491556C2779756493 @default.
- W4280491556 hasConceptScore W4280491556C2780035454 @default.
- W4280491556 hasConceptScore W4280491556C86803240 @default.
- W4280491556 hasConceptScore W4280491556C89423630 @default.
- W4280491556 hasConceptScore W4280491556C98274493 @default.
- W4280491556 hasLocation W42804915561 @default.
- W4280491556 hasLocation W42804915562 @default.
- W4280491556 hasOpenAccess W4280491556 @default.
- W4280491556 hasPrimaryLocation W42804915561 @default.
- W4280491556 hasRelatedWork W1534087834 @default.