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- W4280491743 abstract "In the past 40 years, the treatment of locally advanced rectal cancer has evolved with the addition of radiotherapy or chemoradiotherapy and providing (neo)adjuvant systemic chemotherapy to major surgery. However, recent trends have focused on improving our ability to risk-stratify patients and tailoring treatment to achieve the best oncologic outcome while limiting the impact on long-term quality of life. Therefore, there has been increasing interest in pursuing a watch-and-wait approach to achieve organ preservation. Several retro- and prospective studies suggest safety of the watch-and-wait approach, though it is still considered controversial due to limited clinical evidence, concerns about tumor regrowth, and subsequent distant progression. To further reduce treatment, MRI risk stratification, together with patient characteristics and patient preferences, can guide personalized treatment and reserve radiation and chemotherapy for a select patient population. Ultimately, improved options for reassessment during neoadjuvant treatment may allow for more adaptive therapy options based on treatment response. This article provides an overview of some major developments in the multimodal treatment of locally advanced rectal cancer. It reviews some relevant, controversial issues of the watch-and-wait approach and opportunities to personally tailor and reduce treatment. It also reviews the overall neoadjuvant treatment, including total neoadjuvant therapy trials, and how to best optimize for a potential complete response. Finally, it provides an algorithm as an example of how such a personalized, tailored, adaptive, and reduced treatment could look like in the future." @default.
- W4280491743 created "2022-05-22" @default.
- W4280491743 creator A5013384569 @default.
- W4280491743 creator A5054489256 @default.
- W4280491743 creator A5076833348 @default.
- W4280491743 creator A5085296689 @default.
- W4280491743 creator A5087219474 @default.
- W4280491743 date "2022-07-01" @default.
- W4280491743 modified "2023-10-18" @default.
- W4280491743 title "The Multimodal Management of Locally Advanced Rectal Cancer: Making Sense of the New Data" @default.
- W4280491743 cites W129347924 @default.
- W4280491743 cites W1764231357 @default.
- W4280491743 cites W1826055758 @default.
- W4280491743 cites W1830146239 @default.
- W4280491743 cites W1880063947 @default.
- W4280491743 cites W1893228501 @default.
- W4280491743 cites W1896630734 @default.
- W4280491743 cites W1899767765 @default.
- W4280491743 cites W1917937632 @default.
- W4280491743 cites W1928621270 @default.
- W4280491743 cites W1964246852 @default.
- W4280491743 cites W1969561516 @default.
- W4280491743 cites W1976964541 @default.
- W4280491743 cites W1977085532 @default.
- W4280491743 cites W1979576510 @default.
- W4280491743 cites W1981682689 @default.
- W4280491743 cites W1982777873 @default.
- W4280491743 cites W1983829780 @default.
- W4280491743 cites W1996720227 @default.
- W4280491743 cites W2003852622 @default.
- W4280491743 cites W2009925508 @default.
- W4280491743 cites W2014274213 @default.
- W4280491743 cites W2023895202 @default.
- W4280491743 cites W2025885442 @default.
- W4280491743 cites W2033232416 @default.
- W4280491743 cites W2036069859 @default.
- W4280491743 cites W2036704220 @default.
- W4280491743 cites W2047425373 @default.
- W4280491743 cites W2050020104 @default.
- W4280491743 cites W2055283501 @default.
- W4280491743 cites W2055949217 @default.
- W4280491743 cites W2057901226 @default.
- W4280491743 cites W2072201955 @default.
- W4280491743 cites W2082300679 @default.
- W4280491743 cites W2085574583 @default.
- W4280491743 cites W2095439981 @default.
- W4280491743 cites W2099571006 @default.
- W4280491743 cites W2101998870 @default.
- W4280491743 cites W2102724015 @default.
- W4280491743 cites W2106014206 @default.
- W4280491743 cites W2107249978 @default.
- W4280491743 cites W2107710830 @default.
- W4280491743 cites W2108083343 @default.
- W4280491743 cites W2111510200 @default.
- W4280491743 cites W2112693548 @default.
- W4280491743 cites W2113029107 @default.
- W4280491743 cites W2113243295 @default.
- W4280491743 cites W2113353705 @default.
- W4280491743 cites W2122262640 @default.
- W4280491743 cites W2123377696 @default.
- W4280491743 cites W2124297369 @default.
- W4280491743 cites W2124886112 @default.
- W4280491743 cites W2125452425 @default.
- W4280491743 cites W2126478505 @default.
- W4280491743 cites W2130192128 @default.
- W4280491743 cites W2138728054 @default.
- W4280491743 cites W2143655828 @default.
- W4280491743 cites W2144717403 @default.
- W4280491743 cites W2155994495 @default.
- W4280491743 cites W2156074757 @default.
- W4280491743 cites W2159691094 @default.
- W4280491743 cites W2159919969 @default.
- W4280491743 cites W2165147735 @default.
- W4280491743 cites W2168323176 @default.
- W4280491743 cites W2172147031 @default.
- W4280491743 cites W2173887102 @default.
- W4280491743 cites W2207554953 @default.
- W4280491743 cites W2224855646 @default.
- W4280491743 cites W2393314511 @default.
- W4280491743 cites W2416602815 @default.
- W4280491743 cites W2492547438 @default.
- W4280491743 cites W2494683451 @default.
- W4280491743 cites W2547432167 @default.
- W4280491743 cites W2566662178 @default.
- W4280491743 cites W2586403573 @default.
- W4280491743 cites W2587952918 @default.
- W4280491743 cites W2593170853 @default.
- W4280491743 cites W2602825351 @default.
- W4280491743 cites W2768209852 @default.
- W4280491743 cites W2793017953 @default.
- W4280491743 cites W2809278331 @default.
- W4280491743 cites W2883286298 @default.
- W4280491743 cites W2893799499 @default.
- W4280491743 cites W2910132967 @default.
- W4280491743 cites W2954929188 @default.
- W4280491743 cites W2979779879 @default.
- W4280491743 cites W3011062394 @default.
- W4280491743 cites W3030094954 @default.