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- W4280492220 abstract "Background: It remains largely unknown whether endothelial biomarkers can be used to predict thromboembolism in critically ill patients with an acquired coagulopathy. Materials & methods: The ability of syndecan-1, P-selectin and microRNA expressions to predict thromboembolism were assessed in 40 critically ill coagulopathic patients. Results: The area under the receiver operating characteristic curves for syndecan-1, P-selectin and the four differentially expressed microRNAs - determined by real-time qPCR analysis - to predict thromboembolism (n = 10, 25%) were 0.71 (95% CI: 0.52-0.89), 0.73 (95% CI: 0.52-0.95) and >0.80, respectively. Syndecan-1 and P-selectin concentrations were also significantly correlated with one another (R = 0.41, p = 0.008). Conclusion: Endothelial function biomarkers, including endothelial microRNA expressions, were associated with subsequent thromboembolism in critically ill patients who had a deranged coagulation profile." @default.
- W4280492220 created "2022-05-22" @default.
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- W4280492220 date "2022-05-18" @default.
- W4280492220 modified "2023-10-17" @default.
- W4280492220 title "Endothelial biomarkers of thrombosis in critically ill patients with acquired coagulopathy: a prospective cohort study" @default.
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- W4280492220 doi "https://doi.org/10.2217/bmm-2021-0576" @default.
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