Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280492279> ?p ?o ?g. }
- W4280492279 endingPage "7277" @default.
- W4280492279 startingPage "7272" @default.
- W4280492279 abstract "Nitroreductase (NTR), one of the flavin-dependent enzymes and an upregulated enzyme under tumor hypoxia, has been studied for decades. Many fluorescent probes were developed to detect NTR activity; however, these probes tend to diffuse away from their reaction site (NTR) inevitably, leading to inappropriate sample fixation, lower accuracy of NTR localization, and weaker signal-to-noise ratio. Herein, we present the design, synthesis, in vitro evaluation, and biological applications of an NTR-activatable fluorogenic and labeling probe FY. By integrating with quinone methide (QM) proximity-based protein labeling, the additional fluoromethyl group on FY serves as a potential origin of QM. Compared with conventional fluorescent probes, this new NTR probe not only offers mitochondrial localizable and fluorogenic response but also achieves permanent retention on the site of activation with an enhanced spatial resolution to improve the detection sensitivity even after cell fixation. We believe our work could offer an expandable synthetic approach to develop these permanent labeling and imaging fluorescence probes for deciphering complex biological events." @default.
- W4280492279 created "2022-05-22" @default.
- W4280492279 creator A5019471481 @default.
- W4280492279 creator A5021110763 @default.
- W4280492279 creator A5027004576 @default.
- W4280492279 creator A5035470046 @default.
- W4280492279 creator A5050039619 @default.
- W4280492279 creator A5064050037 @default.
- W4280492279 creator A5066189734 @default.
- W4280492279 date "2022-05-12" @default.
- W4280492279 modified "2023-10-16" @default.
- W4280492279 title "Fluorogenic and Mitochondria-Localizable Probe Enables Selective Labeling and Imaging of Nitroreductase" @default.
- W4280492279 cites W1966925547 @default.
- W4280492279 cites W2002051679 @default.
- W4280492279 cites W2004401447 @default.
- W4280492279 cites W2009465544 @default.
- W4280492279 cites W2024903578 @default.
- W4280492279 cites W2029722726 @default.
- W4280492279 cites W2069518226 @default.
- W4280492279 cites W2115880913 @default.
- W4280492279 cites W2177603935 @default.
- W4280492279 cites W2313769716 @default.
- W4280492279 cites W2425681130 @default.
- W4280492279 cites W2474530771 @default.
- W4280492279 cites W2510549933 @default.
- W4280492279 cites W2514937118 @default.
- W4280492279 cites W2605407725 @default.
- W4280492279 cites W2736797790 @default.
- W4280492279 cites W2792473367 @default.
- W4280492279 cites W2793948026 @default.
- W4280492279 cites W2795976152 @default.
- W4280492279 cites W2889569394 @default.
- W4280492279 cites W2909706609 @default.
- W4280492279 cites W2943362234 @default.
- W4280492279 cites W2977788202 @default.
- W4280492279 cites W2988357995 @default.
- W4280492279 cites W2989822289 @default.
- W4280492279 cites W3009122604 @default.
- W4280492279 cites W3025242705 @default.
- W4280492279 cites W3041483557 @default.
- W4280492279 cites W3081294612 @default.
- W4280492279 cites W3095873522 @default.
- W4280492279 cites W3132899487 @default.
- W4280492279 cites W3199808882 @default.
- W4280492279 cites W3208579898 @default.
- W4280492279 doi "https://doi.org/10.1021/acs.analchem.2c00512" @default.
- W4280492279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35549110" @default.
- W4280492279 hasPublicationYear "2022" @default.
- W4280492279 type Work @default.
- W4280492279 citedByCount "14" @default.
- W4280492279 countsByYear W42804922792022 @default.
- W4280492279 countsByYear W42804922792023 @default.
- W4280492279 crossrefType "journal-article" @default.
- W4280492279 hasAuthorship W4280492279A5019471481 @default.
- W4280492279 hasAuthorship W4280492279A5021110763 @default.
- W4280492279 hasAuthorship W4280492279A5027004576 @default.
- W4280492279 hasAuthorship W4280492279A5035470046 @default.
- W4280492279 hasAuthorship W4280492279A5050039619 @default.
- W4280492279 hasAuthorship W4280492279A5064050037 @default.
- W4280492279 hasAuthorship W4280492279A5066189734 @default.
- W4280492279 hasConcept C121332964 @default.
- W4280492279 hasConcept C12554922 @default.
- W4280492279 hasConcept C145169222 @default.
- W4280492279 hasConcept C181199279 @default.
- W4280492279 hasConcept C185592680 @default.
- W4280492279 hasConcept C21951064 @default.
- W4280492279 hasConcept C2781326480 @default.
- W4280492279 hasConcept C33093398 @default.
- W4280492279 hasConcept C552990157 @default.
- W4280492279 hasConcept C55493867 @default.
- W4280492279 hasConcept C62520636 @default.
- W4280492279 hasConcept C86803240 @default.
- W4280492279 hasConcept C91881484 @default.
- W4280492279 hasConceptScore W4280492279C121332964 @default.
- W4280492279 hasConceptScore W4280492279C12554922 @default.
- W4280492279 hasConceptScore W4280492279C145169222 @default.
- W4280492279 hasConceptScore W4280492279C181199279 @default.
- W4280492279 hasConceptScore W4280492279C185592680 @default.
- W4280492279 hasConceptScore W4280492279C21951064 @default.
- W4280492279 hasConceptScore W4280492279C2781326480 @default.
- W4280492279 hasConceptScore W4280492279C33093398 @default.
- W4280492279 hasConceptScore W4280492279C552990157 @default.
- W4280492279 hasConceptScore W4280492279C55493867 @default.
- W4280492279 hasConceptScore W4280492279C62520636 @default.
- W4280492279 hasConceptScore W4280492279C86803240 @default.
- W4280492279 hasConceptScore W4280492279C91881484 @default.
- W4280492279 hasFunder F4320321001 @default.
- W4280492279 hasFunder F4320329878 @default.
- W4280492279 hasIssue "20" @default.
- W4280492279 hasLocation W42804922791 @default.
- W4280492279 hasLocation W42804922792 @default.
- W4280492279 hasOpenAccess W4280492279 @default.
- W4280492279 hasPrimaryLocation W42804922791 @default.
- W4280492279 hasRelatedWork W1489452981 @default.
- W4280492279 hasRelatedWork W2003266661 @default.
- W4280492279 hasRelatedWork W2074214755 @default.
- W4280492279 hasRelatedWork W2118180263 @default.
- W4280492279 hasRelatedWork W2135491076 @default.