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• W4280492289 abstract "Life-threatening ventricular arrhythmias and sudden cardiac death (SCD) in young individuals may be of genetic origin and related to inherited arrhythmogenic diseases (IAD), either cardiomyopathies or channelopathies. In patients with IAD at risk of SCD, the implantable cardioverter-defibrillator (ICD) provides the most effective life-saving therapy. Young patients with IAD have a predominantly arrhythmia-related prognosis, so that they may survive for many decades with nearly normal life expectancy thanks to the protection against SCD provided by the ICD. (1,2). However, the improvement of survival by the ICD therapy is associated with a significant rate of inappropriate discharges and lead-related complications which may lead to an increase of long-term morbidity and mortality. Particularly, inappropriate shocks (IS) caused by either supraventricular tachycardia or abnormal sensing (due to T-or P-wave oversensing, lead fracture or electromagnetic interference) have the potential to reduce the patient’'s qualityoflife and compromise the ICD therapy acceptance. Accordingly, the risk/benefit ratio should be carefully assessed when considering ICD implantation for primary prevention, mostly in patients with IAD, and a high priority should be given to prevent IS by means of adequate device type, targeted device programming, and modern discriminating software [ [1] Olde Nordkamp L.R. Postema P.G. Knops R.E. et al. Implantable cardioverter-defibrillator harm in young patients with inherited arrhythmia syndromes: a systematic review and metaanalysis of inappropriate shocks and complications. Heart Rhythm. 2016; 13: 443-454 Abstract Full Text Full Text PDF PubMed Scopus (151) Google Scholar , [2] Migliore F. Silvano M. Zorzi A. et al. Implantable cardioverter defibrillator therapy in young patients with cardiomyopathies and channelopathies: a single Italian Centre experience. J. Cardiovasc. Med. 2016; 17: 485-493 Crossref Scopus (15) Google Scholar ]. In recent years, device manufacturers focused technological improvements on the reduction of inappropriate ICD interventions, which resulted into more effective device programming models and improved arrhythmia detection algorithms [ [3] Wilkoff B.L. Fauchier L. Stiles M.K. et al. 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing. Heart Rhythm. 2016; 13: e50-e86 Abstract Full Text Full Text PDF PubMed Scopus (150) Google Scholar , [4] Auricchio A. Schloss E.J. Kurita T. et al. Low inappropriate shock rates in patients with single- and dual/triple-chamber implantable cardioverter-defibrillators using a novel suite of detection algorithms: PainFree SST trial primary results. Heart Rhythm. 2015; 12: 926-936 Abstract Full Text Full Text PDF PubMed Scopus (94) Google Scholar ]. The SmartShock Technology™ (SST) by Medtronic, Minneapolis, USA, consists of a systematic adoption of novel enhanced detection algorithms in conjunction with routine implementation of a contemporary evidence-based ICD programming (long detection time and antitachicardia pacing use). In the PainFree SST study [ [4] Auricchio A. Schloss E.J. Kurita T. et al. Low inappropriate shock rates in patients with single- and dual/triple-chamber implantable cardioverter-defibrillators using a novel suite of detection algorithms: PainFree SST trial primary results. Heart Rhythm. 2015; 12: 926-936 Abstract Full Text Full Text PDF PubMed Scopus (94) Google Scholar ] this combined approach was demonstrated to substantially lower the rate of IS in a large “real-word” population of ICD patients. However, data on the outcome of patients with IAD who received new-generation ICDs with SST technology are lacking. Performance evaluation of implantable cardioverter-defibrillators with SmartShock technology in patients with inherited arrhythmogenic diseasesInternational Journal of CardiologyVol. 350PreviewPatients with inherited arrhythmogenic diseases (IADs) are often prescribed preventative implantable cardioverter-defibrillators (ICDs) to manage their increased sudden cardiac arrest risk. However, it has been suggested that ICDs in IAD patients may come with additional risk. We aimed to leverage the PainFree SmartShock Technology dataset to compare inappropriate therapies, appropriate therapies, mortality, and complications in patients with and without IAD. Full-Text PDF" @default.
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• W4280492289 title "Implantable defibrillator in patients with inherited arrhythmogenic diseases: Are inapproppriate shocks preventable?" @default.
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• W4280492289 doi "https://doi.org/10.1016/j.ijcard.2022.05.019" @default.
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