Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280492300> ?p ?o ?g. }
- W4280492300 abstract "The dorsal lingual epithelium, which is composed of taste buds and keratinocytes differentiated from K14+ basal cells, discriminates taste compounds and maintains the epithelial barrier. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotic cells. How METTL3-mediated m6A modification regulates K14+ basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear. Here we show knockout of Mettl3 in K14+ cells reduced the taste buds and enhanced keratinocytes. Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds. Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization, but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery. Mechanically, we revealed that the most frequent m6A modifications were enriched in Hippo and Wnt signaling, and specific peaks were observed near the stop codons of Lats1 and FZD7. Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation." @default.
- W4280492300 created "2022-05-22" @default.
- W4280492300 creator A5000748029 @default.
- W4280492300 creator A5026351001 @default.
- W4280492300 creator A5027605871 @default.
- W4280492300 creator A5027605982 @default.
- W4280492300 creator A5037316749 @default.
- W4280492300 creator A5043534663 @default.
- W4280492300 creator A5044371823 @default.
- W4280492300 creator A5046225712 @default.
- W4280492300 creator A5054383087 @default.
- W4280492300 creator A5066056560 @default.
- W4280492300 creator A5070775744 @default.
- W4280492300 date "2022-05-17" @default.
- W4280492300 modified "2023-10-13" @default.
- W4280492300 title "METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis" @default.
- W4280492300 cites W1482923899 @default.
- W4280492300 cites W1965193260 @default.
- W4280492300 cites W1977982974 @default.
- W4280492300 cites W1980983731 @default.
- W4280492300 cites W1986988560 @default.
- W4280492300 cites W1987966039 @default.
- W4280492300 cites W1996864088 @default.
- W4280492300 cites W2002458471 @default.
- W4280492300 cites W2006778392 @default.
- W4280492300 cites W2010713810 @default.
- W4280492300 cites W2018623578 @default.
- W4280492300 cites W2026279127 @default.
- W4280492300 cites W2035905956 @default.
- W4280492300 cites W2042502174 @default.
- W4280492300 cites W2046872526 @default.
- W4280492300 cites W2065847836 @default.
- W4280492300 cites W2067960353 @default.
- W4280492300 cites W2091235283 @default.
- W4280492300 cites W2093764457 @default.
- W4280492300 cites W2094988282 @default.
- W4280492300 cites W2132264180 @default.
- W4280492300 cites W2148043557 @default.
- W4280492300 cites W2165547003 @default.
- W4280492300 cites W2192389430 @default.
- W4280492300 cites W2403990263 @default.
- W4280492300 cites W2520925527 @default.
- W4280492300 cites W2546967042 @default.
- W4280492300 cites W2570618306 @default.
- W4280492300 cites W2623054919 @default.
- W4280492300 cites W2737629683 @default.
- W4280492300 cites W2746255049 @default.
- W4280492300 cites W2748338775 @default.
- W4280492300 cites W2754499625 @default.
- W4280492300 cites W2770747479 @default.
- W4280492300 cites W2792699897 @default.
- W4280492300 cites W2803922306 @default.
- W4280492300 cites W2900347078 @default.
- W4280492300 cites W2951746943 @default.
- W4280492300 cites W2955181393 @default.
- W4280492300 cites W2968332102 @default.
- W4280492300 cites W2969294245 @default.
- W4280492300 cites W2986419300 @default.
- W4280492300 cites W2990094921 @default.
- W4280492300 cites W2992958546 @default.
- W4280492300 cites W2999012956 @default.
- W4280492300 cites W3004815839 @default.
- W4280492300 cites W3028187297 @default.
- W4280492300 cites W3037963954 @default.
- W4280492300 cites W3081821563 @default.
- W4280492300 cites W3087184075 @default.
- W4280492300 cites W3101227947 @default.
- W4280492300 cites W3133900342 @default.
- W4280492300 cites W3137296636 @default.
- W4280492300 cites W3162748936 @default.
- W4280492300 cites W3164600279 @default.
- W4280492300 cites W3165005534 @default.
- W4280492300 cites W3172723995 @default.
- W4280492300 cites W3173956872 @default.
- W4280492300 cites W4200530982 @default.
- W4280492300 cites W4226347960 @default.
- W4280492300 cites W423531153 @default.
- W4280492300 doi "https://doi.org/10.1038/s41368-022-00176-2" @default.
- W4280492300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35581183" @default.
- W4280492300 hasPublicationYear "2022" @default.
- W4280492300 type Work @default.
- W4280492300 citedByCount "5" @default.
- W4280492300 countsByYear W42804923002022 @default.
- W4280492300 countsByYear W42804923002023 @default.
- W4280492300 crossrefType "journal-article" @default.
- W4280492300 hasAuthorship W4280492300A5000748029 @default.
- W4280492300 hasAuthorship W4280492300A5026351001 @default.
- W4280492300 hasAuthorship W4280492300A5027605871 @default.
- W4280492300 hasAuthorship W4280492300A5027605982 @default.
- W4280492300 hasAuthorship W4280492300A5037316749 @default.
- W4280492300 hasAuthorship W4280492300A5043534663 @default.
- W4280492300 hasAuthorship W4280492300A5044371823 @default.
- W4280492300 hasAuthorship W4280492300A5046225712 @default.
- W4280492300 hasAuthorship W4280492300A5054383087 @default.
- W4280492300 hasAuthorship W4280492300A5066056560 @default.
- W4280492300 hasAuthorship W4280492300A5070775744 @default.
- W4280492300 hasBestOaLocation W42804923001 @default.
- W4280492300 hasConcept C134018914 @default.
- W4280492300 hasConcept C137620995 @default.
- W4280492300 hasConcept C171056886 @default.