Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280492344> ?p ?o ?g. }
- W4280492344 abstract "Abstract Freeze tolerance is an amazing overwintering strategy that enables ectotherms to occupy new niches and survive in cold climates. However, the genetic basis underpinning this ecologically relevant adaptation is largely unknown. Amur sleeper is the only known freeze-tolerant fish species that can overwinter with its entire body frozen in ice. Here, we sequenced the chromosome-level genome of the Amur sleeper and performed comparative genomic, transcriptomic, and metabolomic analyses to investigate this remarkable adaptation. Phylogenetic analyses showed that the Amur sleeper diverged from its close relative with no cold hardiness about 15.07 million years ago and revealed two unusual population expansions during the glacial epochs. Integrative omics data identified a synchronous regulation of genes and metabolites involved in hypometabolism and cellular stress response, and several related genes showed strong evidence of accelerated evolution and positive selection. Potential evolutionary innovations that might aid in freezing survival were found to be associated with the dynamic rearrangement of the cytoskeleton to maintain cell viability, redistribution of water and cryoprotectants to limit cell volume reduction, and inhibition in nerve activity to facilitate dormancy, demonstrating a coordinated evolution for this complex adaptation. Overall, our work provides valuable resources and opportunities to unveil the genetic basis of freeze tolerance adaptation in ectothermic vertebrates." @default.
- W4280492344 created "2022-05-22" @default.
- W4280492344 creator A5007386244 @default.
- W4280492344 creator A5008623963 @default.
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- W4280492344 creator A5047873289 @default.
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- W4280492344 creator A5061899878 @default.
- W4280492344 creator A5062792660 @default.
- W4280492344 creator A5084174966 @default.
- W4280492344 creator A5086259776 @default.
- W4280492344 date "2022-05-11" @default.
- W4280492344 modified "2023-10-15" @default.
- W4280492344 title "Multiple omic investigations of freeze tolerance adaptation in the aquatic ectothermic vertebrate, the Amur sleeper" @default.
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