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• W4280492459 abstract "Calcium homeostasis and signaling processes in Saccharomyces cerevisiae , as well as in any eukaryotic organism, depend on various transporters and channels located on both the plasma and intracellular membranes. The activity of these proteins is regulated by a number of feedback mechanisms that act through the calmodulin-calcineurin pathway. When exposed to hypotonic shock (HTS), yeast cells respond with an increased cytosolic calcium transient, which seems to be conditioned by the opening of stretch-activated channels. To better understand the role of each channel and transporter involved in the generation and recovery of the calcium transient—and of their feedback regulations—we defined and analyzed a mathematical model of the calcium signaling response to HTS in yeast cells. The model was validated by comparing the simulation outcomes with calcium concentration variations before and during the HTS response, which were observed experimentally in both wild-type and mutant strains. Our results show that calcium normally enters the cell through the High Affinity Calcium influx System and mechanosensitive channels. The increase of the plasma membrane tension, caused by HTS, boosts the opening probability of mechanosensitive channels. This event causes a sudden calcium pulse that is rapidly dissipated by the activity of the vacuolar transporter Pmc1. According to model simulations, the role of another vacuolar transporter, Vcx1, is instead marginal, unless calcineurin is inhibited or removed. Our results also suggest that the mechanosensitive channels are subject to a calcium-dependent feedback inhibition, possibly involving calmodulin. Noteworthy, the model predictions are in accordance with literature results concerning some aspects of calcium homeostasis and signaling that were not specifically addressed within the model itself, suggesting that it actually depicts all the main cellular components and interactions that constitute the HTS calcium pathway, and thus can correctly reproduce the shaping of the calcium signature by calmodulin- and calcineurin-dependent complex regulations. The model predictions also allowed to provide an interpretation of different regulatory schemes involved in calcium handling in both wild-type and mutants yeast strains. The model could be easily extended to represent different calcium signals in other eukaryotic cells." @default.
• W4280492459 created "2022-05-22" @default.
• W4280492459 creator A5013723473 @default.
• W4280492459 creator A5023017678 @default.
• W4280492459 creator A5043650939 @default.
• W4280492459 creator A5050232933 @default.
• W4280492459 creator A5072712347 @default.
• W4280492459 creator A5081323030 @default.
• W4280492459 date "2022-05-18" @default.
• W4280492459 modified "2023-10-18" @default.
• W4280492459 title "Modeling Calcium Signaling in S. cerevisiae Highlights the Role and Regulation of the Calmodulin-Calcineurin Pathway in Response to Hypotonic Shock" @default.
• W4280492459 cites W1485297825 @default.
• W4280492459 cites W1488647821 @default.
• W4280492459 cites W1504082382 @default.
• W4280492459 cites W1530464904 @default.
• W4280492459 cites W1579765465 @default.
• W4280492459 cites W1599277155 @default.
• W4280492459 cites W1647306826 @default.
• W4280492459 cites W1748180543 @default.
• W4280492459 cites W1767701883 @default.
• W4280492459 cites W1774442194 @default.
• W4280492459 cites W177621860 @default.
• W4280492459 cites W1876704297 @default.
• W4280492459 cites W1888736125 @default.
• W4280492459 cites W1897747135 @default.
• W4280492459 cites W1920232352 @default.
• W4280492459 cites W1953308090 @default.
• W4280492459 cites W1967597269 @default.
• W4280492459 cites W1968410172 @default.
• W4280492459 cites W1970084867 @default.
• W4280492459 cites W1970102548 @default.
• W4280492459 cites W1970247880 @default.
• W4280492459 cites W1970280327 @default.
• W4280492459 cites W1970753410 @default.
• W4280492459 cites W1972838815 @default.
• W4280492459 cites W1976812939 @default.
• W4280492459 cites W1977730145 @default.
• W4280492459 cites W1979196237 @default.
• W4280492459 cites W1979246102 @default.
• W4280492459 cites W1980558682 @default.
• W4280492459 cites W1991870376 @default.
• W4280492459 cites W1992182416 @default.
• W4280492459 cites W1994201260 @default.
• W4280492459 cites W2000569688 @default.
• W4280492459 cites W2003114036 @default.
• W4280492459 cites W2003945747 @default.
• W4280492459 cites W2007459574 @default.
• W4280492459 cites W2009713636 @default.
• W4280492459 cites W2015426350 @default.
• W4280492459 cites W2016767899 @default.
• W4280492459 cites W2017226237 @default.
• W4280492459 cites W2017893374 @default.
• W4280492459 cites W2026402396 @default.
• W4280492459 cites W2029693312 @default.
• W4280492459 cites W2031053624 @default.
• W4280492459 cites W2032354328 @default.
• W4280492459 cites W2035317443 @default.
• W4280492459 cites W2036145275 @default.
• W4280492459 cites W2037405765 @default.
• W4280492459 cites W2038823160 @default.
• W4280492459 cites W2039694257 @default.
• W4280492459 cites W2039819844 @default.
• W4280492459 cites W2040264973 @default.
• W4280492459 cites W2041767840 @default.
• W4280492459 cites W2044091418 @default.
• W4280492459 cites W2045785885 @default.
• W4280492459 cites W2046526184 @default.
• W4280492459 cites W2049584870 @default.
• W4280492459 cites W2049747046 @default.
• W4280492459 cites W2050140351 @default.
• W4280492459 cites W2050695823 @default.
• W4280492459 cites W2051959027 @default.
• W4280492459 cites W2052544958 @default.
• W4280492459 cites W2056406543 @default.
• W4280492459 cites W2058100859 @default.
• W4280492459 cites W2061962822 @default.
• W4280492459 cites W2066080955 @default.
• W4280492459 cites W2073851790 @default.
• W4280492459 cites W2074743540 @default.
• W4280492459 cites W2075307062 @default.
• W4280492459 cites W2076136942 @default.
• W4280492459 cites W2078173309 @default.
• W4280492459 cites W2078785949 @default.
• W4280492459 cites W2084567278 @default.
• W4280492459 cites W2085550063 @default.
• W4280492459 cites W2089323144 @default.
• W4280492459 cites W2090819199 @default.
• W4280492459 cites W2092415615 @default.
• W4280492459 cites W2093005137 @default.
• W4280492459 cites W2093695208 @default.
• W4280492459 cites W2098123098 @default.
• W4280492459 cites W2099586601 @default.
• W4280492459 cites W2102653059 @default.
• W4280492459 cites W2106754534 @default.
• W4280492459 cites W2107618142 @default.
• W4280492459 cites W2107902741 @default.
• W4280492459 cites W2108367015 @default.
• W4280492459 cites W2110056793 @default.
• W4280492459 cites W2110949951 @default.
• W4280492459 cites W2111698016 @default.

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