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- W4280492508 startingPage "229" @default.
- W4280492508 abstract "Abstract People with Alzheimer’s disease (AD) and delusions have worse quality of life and prognosis. However, early markers of delusions have not been identified yet. The present study investigated whether there are any detectable differences in grey matter (GM) volume and cognitive changes in the year before symptom onset between patients with AD who did and did not develop delusions. Two matched samples of AD patients, 63 who did (PT-D) and 63 who did not develop delusions (PT-ND) over 1 year, were identified from the Alzheimer’s Disease Neuroimaging Initiative database. The Neuropsychiatric Inventory (NPI) was used to assess the presence of delusions. Sixty-three additional matched healthy controls (HC) were selected. Repeated-measures ANCOVA models were used to investigate group-by-time effects on the volume of selected GM regions of interest and on cognitive performance. No neurocognitive differences were observed between patient groups prior to symptom onset. Greater episodic memory decline and GM loss in bilateral caudate nuclei, medio-temporal and midline cingulo-parietal regions were found in the PT-D compared with the PT-ND group. A pattern of faster GM loss in brain areas typically affected by AD and in cortical and subcortical targets of dopaminergic pathways, paralleled by worsening of episodic memory and behavioural symptoms, may explain the emergence of delusions in patients with AD." @default.
- W4280492508 created "2022-05-22" @default.
- W4280492508 creator A5036374008 @default.
- W4280492508 creator A5046521053 @default.
- W4280492508 creator A5089820600 @default.
- W4280492508 date "2022-05-13" @default.
- W4280492508 modified "2023-09-26" @default.
- W4280492508 title "Accelerated atrophy in dopaminergic targets and medial temporo-parietal regions precedes the onset of delusions in patients with Alzheimer’s disease" @default.
- W4280492508 cites W1490814199 @default.
- W4280492508 cites W1516190726 @default.
- W4280492508 cites W1578353596 @default.
- W4280492508 cites W1588835084 @default.
- W4280492508 cites W1696133229 @default.
- W4280492508 cites W1970166163 @default.
- W4280492508 cites W1977177972 @default.
- W4280492508 cites W1979883598 @default.
- W4280492508 cites W1986394740 @default.
- W4280492508 cites W1992195714 @default.
- W4280492508 cites W1995735916 @default.
- W4280492508 cites W1996455205 @default.
- W4280492508 cites W1999973368 @default.
- W4280492508 cites W2011838459 @default.
- W4280492508 cites W2012433212 @default.
- W4280492508 cites W2013372828 @default.
- W4280492508 cites W2033499429 @default.
- W4280492508 cites W2039588423 @default.
- W4280492508 cites W2039731390 @default.
- W4280492508 cites W2046090892 @default.
- W4280492508 cites W2054251156 @default.
- W4280492508 cites W2058161128 @default.
- W4280492508 cites W2069257450 @default.
- W4280492508 cites W2077689003 @default.
- W4280492508 cites W2078524519 @default.
- W4280492508 cites W2079925329 @default.
- W4280492508 cites W2080514370 @default.
- W4280492508 cites W2091570747 @default.
- W4280492508 cites W2092988317 @default.
- W4280492508 cites W2094134651 @default.
- W4280492508 cites W2097643314 @default.
- W4280492508 cites W2102763546 @default.
- W4280492508 cites W2104230802 @default.
- W4280492508 cites W2105121811 @default.
- W4280492508 cites W2107471397 @default.
- W4280492508 cites W2111464173 @default.
- W4280492508 cites W2117324942 @default.
- W4280492508 cites W2118960860 @default.
- W4280492508 cites W2119848633 @default.
- W4280492508 cites W2123633329 @default.
- W4280492508 cites W2136435696 @default.
- W4280492508 cites W2138305487 @default.
- W4280492508 cites W2138883123 @default.
- W4280492508 cites W2139888322 @default.
- W4280492508 cites W2153710273 @default.
- W4280492508 cites W2164697965 @default.
- W4280492508 cites W2165384648 @default.
- W4280492508 cites W2166740009 @default.
- W4280492508 cites W2267741762 @default.
- W4280492508 cites W2285848849 @default.
- W4280492508 cites W2325014163 @default.
- W4280492508 cites W2375334377 @default.
- W4280492508 cites W2484481324 @default.
- W4280492508 cites W2521453157 @default.
- W4280492508 cites W2564576963 @default.
- W4280492508 cites W2572260688 @default.
- W4280492508 cites W2607359736 @default.
- W4280492508 cites W2611313593 @default.
- W4280492508 cites W2619097621 @default.
- W4280492508 cites W2736567829 @default.
- W4280492508 cites W2741112874 @default.
- W4280492508 cites W2758379647 @default.
- W4280492508 cites W2761985718 @default.
- W4280492508 cites W2765958048 @default.
- W4280492508 cites W2789457320 @default.
- W4280492508 cites W2789976306 @default.
- W4280492508 cites W2798054687 @default.
- W4280492508 cites W2801997553 @default.
- W4280492508 cites W2811410147 @default.
- W4280492508 cites W2883207460 @default.
- W4280492508 cites W2888617722 @default.
- W4280492508 cites W2890722904 @default.
- W4280492508 cites W2892659249 @default.
- W4280492508 cites W2894570760 @default.
- W4280492508 cites W2894852167 @default.
- W4280492508 cites W2906768105 @default.
- W4280492508 cites W2916566999 @default.
- W4280492508 cites W2926660217 @default.
- W4280492508 cites W2965465990 @default.
- W4280492508 cites W2971557946 @default.
- W4280492508 cites W2971765896 @default.
- W4280492508 cites W2972525987 @default.
- W4280492508 cites W2995883381 @default.
- W4280492508 cites W3003915155 @default.
- W4280492508 cites W3012394019 @default.
- W4280492508 cites W3014908280 @default.
- W4280492508 cites W3019251590 @default.
- W4280492508 cites W3084438809 @default.
- W4280492508 cites W3084970060 @default.
- W4280492508 cites W3094792487 @default.