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- W4280492541 abstract "ABSTRACT The fibroblast growth factor (FGF) signalling pathway plays various roles during vertebrate embryogenesis, from mesoderm formation to brain patterning. This diversity of functions relies on the fact that vertebrates possess the largest FGF gene complement among metazoans. In the cephalochordate amphioxus, which belongs to the chordate clade together with vertebrates and tunicates, we have previously shown that the main role of FGF during early development is the control of rostral somite formation. Inhibition of this signalling pathway induces the loss of these structures, resulting in an embryo without anterior segmented mesoderm, as in the vertebrate head. Here, by combining several approaches, we show that the anterior presumptive paraxial mesoderm cells acquire an anterior axial fate when FGF signal is inhibited and that they are later incorporated in the anterior notochord. Our analysis of notochord formation in wild type and in embryos in which FGF signalling is inhibited also reveals that amphioxus anterior notochord presents transient prechordal plate features. Altogether, our results give insight into how changes in FGF functions during chordate evolution might have participated to the emergence of the complex vertebrate head." @default.
- W4280492541 created "2022-05-22" @default.
- W4280492541 creator A5019722142 @default.
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- W4280492541 creator A5086276762 @default.
- W4280492541 date "2022-05-15" @default.
- W4280492541 modified "2023-10-17" @default.
- W4280492541 title "Functions of the FGF signalling pathway in cephalochordates provide insight into the evolution of the prechordal plate" @default.
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- W4280492541 doi "https://doi.org/10.1242/dev.200252" @default.
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- W4280492541 hasPublicationYear "2022" @default.
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