Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280492620> ?p ?o ?g. }
- W4280492620 endingPage "8298" @default.
- W4280492620 startingPage "8290" @default.
- W4280492620 abstract "6:2 polyfluoroalkyl phosphate diester (6:2 diPAP) has been demonstrated to disrupt reproductive endocrine functions using experimental studies. However, evidence from humans is not available yet. This cross-sectional study aims to assess the relationship between 6:2 diPAP exposure and the testicular function among adult men. A total of 902 men seeking preconception care were included. Plasma 6:2 diPAP concentrations were determined, while the testicular function was assessed via semen quality and reproductive hormones in serum. The association was assessed by multiple linear regression. Stratified analyses by age and body mass index (BMI) were conducted to assess the potential effect modification by these two variables. Regression analyses revealed that 6:2 diPAP exposure was significantly inversely associated with androgens [i.e., total testosterone (TT) and free androgen index (FAI)], markers of testosterone production potential [i.e., TT/luteinizing hormone (LH) and FAI/LH], estradiol, and insulin-like factor 3, a biomarker of Leydig cell function. These associations were robust in sensitivity analyses. However, age and BMI did not modify these associations, and no association was observed between 6:2 diPAP and semen quality. Our study suggests that exposure to 6:2 diPAP may inhibit androgen synthesis and impair Leydig cell function in adult men." @default.
- W4280492620 created "2022-05-22" @default.
- W4280492620 creator A5002939250 @default.
- W4280492620 creator A5031593368 @default.
- W4280492620 creator A5044672924 @default.
- W4280492620 creator A5045432123 @default.
- W4280492620 creator A5060943605 @default.
- W4280492620 creator A5069914148 @default.
- W4280492620 creator A5072334257 @default.
- W4280492620 creator A5082534703 @default.
- W4280492620 date "2022-05-10" @default.
- W4280492620 modified "2023-10-18" @default.
- W4280492620 title "Environmental Exposure to 6:2 Polyfluoroalkyl Phosphate Diester and Impaired Testicular Function in Men" @default.
- W4280492620 cites W1968761382 @default.
- W4280492620 cites W1980515518 @default.
- W4280492620 cites W2011120016 @default.
- W4280492620 cites W2024698672 @default.
- W4280492620 cites W2025159998 @default.
- W4280492620 cites W2025792027 @default.
- W4280492620 cites W2036002592 @default.
- W4280492620 cites W2036638367 @default.
- W4280492620 cites W2056819642 @default.
- W4280492620 cites W2057939761 @default.
- W4280492620 cites W2083884879 @default.
- W4280492620 cites W2092000382 @default.
- W4280492620 cites W2110867138 @default.
- W4280492620 cites W2112558380 @default.
- W4280492620 cites W2113799018 @default.
- W4280492620 cites W2125218472 @default.
- W4280492620 cites W2126460557 @default.
- W4280492620 cites W2126983182 @default.
- W4280492620 cites W2139767645 @default.
- W4280492620 cites W2141674141 @default.
- W4280492620 cites W2155651940 @default.
- W4280492620 cites W2156615891 @default.
- W4280492620 cites W2317886628 @default.
- W4280492620 cites W2318739473 @default.
- W4280492620 cites W2324601245 @default.
- W4280492620 cites W2345562900 @default.
- W4280492620 cites W2521286923 @default.
- W4280492620 cites W2528899831 @default.
- W4280492620 cites W2611143514 @default.
- W4280492620 cites W2765231636 @default.
- W4280492620 cites W2795734533 @default.
- W4280492620 cites W2908760437 @default.
- W4280492620 cites W2968489473 @default.
- W4280492620 cites W2996396622 @default.
- W4280492620 cites W3015979185 @default.
- W4280492620 cites W3033315145 @default.
- W4280492620 cites W3139203073 @default.
- W4280492620 cites W3186790914 @default.
- W4280492620 cites W4206670673 @default.
- W4280492620 doi "https://doi.org/10.1021/acs.est.1c07184" @default.
- W4280492620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35536153" @default.
- W4280492620 hasPublicationYear "2022" @default.
- W4280492620 type Work @default.
- W4280492620 citedByCount "4" @default.
- W4280492620 countsByYear W42804926202023 @default.
- W4280492620 crossrefType "journal-article" @default.
- W4280492620 hasAuthorship W4280492620A5002939250 @default.
- W4280492620 hasAuthorship W4280492620A5031593368 @default.
- W4280492620 hasAuthorship W4280492620A5044672924 @default.
- W4280492620 hasAuthorship W4280492620A5045432123 @default.
- W4280492620 hasAuthorship W4280492620A5060943605 @default.
- W4280492620 hasAuthorship W4280492620A5069914148 @default.
- W4280492620 hasAuthorship W4280492620A5072334257 @default.
- W4280492620 hasAuthorship W4280492620A5082534703 @default.
- W4280492620 hasConcept C126322002 @default.
- W4280492620 hasConcept C134018914 @default.
- W4280492620 hasConcept C16685009 @default.
- W4280492620 hasConcept C2777736315 @default.
- W4280492620 hasConcept C2777911890 @default.
- W4280492620 hasConcept C2778080409 @default.
- W4280492620 hasConcept C2778093475 @default.
- W4280492620 hasConcept C2778575703 @default.
- W4280492620 hasConcept C2779279991 @default.
- W4280492620 hasConcept C2780221984 @default.
- W4280492620 hasConcept C2781197716 @default.
- W4280492620 hasConcept C46699223 @default.
- W4280492620 hasConcept C55493867 @default.
- W4280492620 hasConcept C71315377 @default.
- W4280492620 hasConcept C71924100 @default.
- W4280492620 hasConcept C86803240 @default.
- W4280492620 hasConceptScore W4280492620C126322002 @default.
- W4280492620 hasConceptScore W4280492620C134018914 @default.
- W4280492620 hasConceptScore W4280492620C16685009 @default.
- W4280492620 hasConceptScore W4280492620C2777736315 @default.
- W4280492620 hasConceptScore W4280492620C2777911890 @default.
- W4280492620 hasConceptScore W4280492620C2778080409 @default.
- W4280492620 hasConceptScore W4280492620C2778093475 @default.
- W4280492620 hasConceptScore W4280492620C2778575703 @default.
- W4280492620 hasConceptScore W4280492620C2779279991 @default.
- W4280492620 hasConceptScore W4280492620C2780221984 @default.
- W4280492620 hasConceptScore W4280492620C2781197716 @default.
- W4280492620 hasConceptScore W4280492620C46699223 @default.
- W4280492620 hasConceptScore W4280492620C55493867 @default.
- W4280492620 hasConceptScore W4280492620C71315377 @default.
- W4280492620 hasConceptScore W4280492620C71924100 @default.