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- W4280492718 abstract "Front cover During cerebral cortex development, microtubule dynamics regulation is essential to unfold proper cortical formation, especially during axon formation and outgrowth. Here, the role of Cenpj, a microcephaly gene, in axon growth is described. Aspects of axon growth after gain and loss of function of Cenpj during corpus callosum development in a mouse model were assessed through in utero and ex-vivo electroporation. Results suggest that Cenpj regulates axon growth by destabilizing microtubules through its domain PN2-3 during cortical development. These findings suggest Cenpj as a potential axon regeneration target. Image content Confocal image of developing cortical neurons in culture, fixed and stained with microtubule markers, acetylated a-tubulin (gray) and tyrosinated a-tubulin (red). Nuclei are stained with DAPI (cyan). Read the full article ‘Microcephaly gene Cenpj regulates axonal growth in cortical neurons through microtubule destabilization’ by P. Meneses Iack, D. Rayêe, R. Lent, V. T. Ribeiro-Resende and P. P. Garcez (J. Neurochem. 2022, vol. 161 (4), pp. 320–334) on doi:10.1111/jnc.15568" @default.
- W4280492718 created "2022-05-22" @default.
- W4280492718 date "2022-05-01" @default.
- W4280492718 modified "2023-10-16" @default.
- W4280492718 doi "https://doi.org/10.1111/jnc.v161.4" @default.
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