Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280492844> ?p ?o ?g. }
- W4280492844 abstract "Interstitial cystitis (IC) is a severely debilitating and chronic disorder with unclear etiology and pathophysiology, which makes the diagnosis difficult and treatment challenging. To investigate the role of immunity in IC bladders, we sequenced 135,091 CD45+ immune cells from 15 female patients with IC and 9 controls with stress urinary incontinence using single-cell RNA sequencing (scRNA-seq). 22 immune subpopulations were identified in the constructed landscape. Among them, M2-like macrophages, inflammatory CD14+ macrophages, and conventional dendritic cells had the most communications with other immune cells. Then, a significant increase of central memory CD4+ T cells, regulatory T cells, GZMK+CD8+ T cells, activated B cells, un-switched memory B cells, and neutrophils, and a significant decrease of CD8+ effector T cells, Th17 cells, follicular helper T cells, switched memory B cells, transitional B cells, and macrophages were noted in IC bladders. The enrichment analysis identified a virus-related response during the dynamic change of cell proportion, furthermore, the human polyomavirus-2 was detected with a positive rate of 95% in urine of patients with IC. By integrating the results of scRNA-seq with spatial transcriptomics, we found nearly all immune subpopulations were enriched in the urothelial region or located close to fibroblasts in IC bladders, but they were discovered around urothelium and smooth muscle cells in control bladders. These findings depict the immune landscape for IC and might provide valuable insights into the pathophysiology of IC." @default.
- W4280492844 created "2022-05-22" @default.
- W4280492844 creator A5000576244 @default.
- W4280492844 creator A5000665384 @default.
- W4280492844 creator A5003891578 @default.
- W4280492844 creator A5010720982 @default.
- W4280492844 creator A5011547001 @default.
- W4280492844 creator A5014068004 @default.
- W4280492844 creator A5017138230 @default.
- W4280492844 creator A5028225823 @default.
- W4280492844 creator A5046597133 @default.
- W4280492844 creator A5050868515 @default.
- W4280492844 creator A5054159067 @default.
- W4280492844 creator A5054508756 @default.
- W4280492844 creator A5077614334 @default.
- W4280492844 creator A5079868220 @default.
- W4280492844 creator A5081433760 @default.
- W4280492844 creator A5088021614 @default.
- W4280492844 date "2022-05-20" @default.
- W4280492844 modified "2023-10-03" @default.
- W4280492844 title "Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis" @default.
- W4280492844 cites W131772958 @default.
- W4280492844 cites W1586846969 @default.
- W4280492844 cites W1972100425 @default.
- W4280492844 cites W1972116180 @default.
- W4280492844 cites W1975063227 @default.
- W4280492844 cites W2004378833 @default.
- W4280492844 cites W2059124349 @default.
- W4280492844 cites W2069137464 @default.
- W4280492844 cites W2074200571 @default.
- W4280492844 cites W2088315735 @default.
- W4280492844 cites W2103684127 @default.
- W4280492844 cites W2105790195 @default.
- W4280492844 cites W2106684817 @default.
- W4280492844 cites W2114455877 @default.
- W4280492844 cites W2148670448 @default.
- W4280492844 cites W2161807262 @default.
- W4280492844 cites W2172045319 @default.
- W4280492844 cites W2358421111 @default.
- W4280492844 cites W2395210518 @default.
- W4280492844 cites W2398972915 @default.
- W4280492844 cites W2467510363 @default.
- W4280492844 cites W2467624056 @default.
- W4280492844 cites W2471536144 @default.
- W4280492844 cites W2560111197 @default.
- W4280492844 cites W2588832330 @default.
- W4280492844 cites W2592935721 @default.
- W4280492844 cites W2605187976 @default.
- W4280492844 cites W2625235929 @default.
- W4280492844 cites W2740325876 @default.
- W4280492844 cites W2744347172 @default.
- W4280492844 cites W2747877289 @default.
- W4280492844 cites W2763776271 @default.
- W4280492844 cites W2782685575 @default.
- W4280492844 cites W2790751214 @default.
- W4280492844 cites W2794480084 @default.
- W4280492844 cites W2807880937 @default.
- W4280492844 cites W2887118667 @default.
- W4280492844 cites W2900144939 @default.
- W4280492844 cites W2917457305 @default.
- W4280492844 cites W2922336850 @default.
- W4280492844 cites W2947588677 @default.
- W4280492844 cites W2949243209 @default.
- W4280492844 cites W2949631571 @default.
- W4280492844 cites W2951506174 @default.
- W4280492844 cites W2969669104 @default.
- W4280492844 cites W2970372573 @default.
- W4280492844 cites W2972440873 @default.
- W4280492844 cites W2977187857 @default.
- W4280492844 cites W2999977864 @default.
- W4280492844 cites W3007935255 @default.
- W4280492844 cites W3015493096 @default.
- W4280492844 cites W3083938406 @default.
- W4280492844 cites W3112976705 @default.
- W4280492844 cites W3136164152 @default.
- W4280492844 doi "https://doi.org/10.1038/s41392-022-00962-8" @default.
- W4280492844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35589692" @default.
- W4280492844 hasPublicationYear "2022" @default.
- W4280492844 type Work @default.
- W4280492844 citedByCount "9" @default.
- W4280492844 countsByYear W42804928442022 @default.
- W4280492844 countsByYear W42804928442023 @default.
- W4280492844 crossrefType "journal-article" @default.
- W4280492844 hasAuthorship W4280492844A5000576244 @default.
- W4280492844 hasAuthorship W4280492844A5000665384 @default.
- W4280492844 hasAuthorship W4280492844A5003891578 @default.
- W4280492844 hasAuthorship W4280492844A5010720982 @default.
- W4280492844 hasAuthorship W4280492844A5011547001 @default.
- W4280492844 hasAuthorship W4280492844A5014068004 @default.
- W4280492844 hasAuthorship W4280492844A5017138230 @default.
- W4280492844 hasAuthorship W4280492844A5028225823 @default.
- W4280492844 hasAuthorship W4280492844A5046597133 @default.
- W4280492844 hasAuthorship W4280492844A5050868515 @default.
- W4280492844 hasAuthorship W4280492844A5054159067 @default.
- W4280492844 hasAuthorship W4280492844A5054508756 @default.
- W4280492844 hasAuthorship W4280492844A5077614334 @default.
- W4280492844 hasAuthorship W4280492844A5079868220 @default.
- W4280492844 hasAuthorship W4280492844A5081433760 @default.
- W4280492844 hasAuthorship W4280492844A5088021614 @default.
- W4280492844 hasBestOaLocation W42804928441 @default.