Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280493073> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4280493073 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients are at high risk for developing severe conditions if other comorbidities are present, such as advanced cancer. Although the regulation of immune response is thought to play an important role in the treatment of coronavirus disease 2019 (COVID-19), physicians often have difficulties in selecting the most appropriate treatment. Furthermore, the impact that interrupting breast cancer treatment due to a COVID-19 infection has on patient outcomes is still unknown. Herein we report a case of advanced breast cancer in a patient whose COVID-19 acute respiratory failure was successfully treated with minimal interruption to their anticancer therapy for recurrent breast cancer.A 48-year-old woman developed carcinomatous pleurisy after curative surgery for breast cancer. One month after the initiation of targeted therapy with palbociclib and fulvestrant, the pleural effusion decreased, but soon after she developed a COVID-19 infection. Dexamethasone (8 mg/day) was administered due to a prolonged fever, but her respiratory symptoms got worse and pneumonia appeared on a computed tomography (CT) scan 7 days after hospitalization. Thus, steroid pulse therapy (methylprednisolone 1000 mg/day) was administered for 3 days. Her respiratory condition rapidly improved. Two weeks after hospital discharge, complete regression of pneumonia was confirmed on CT scan, and her targeted therapy was resumed at the same dose and strength. More than 6 months later, her metastatic disease remains stable while on the same treatment. Retrospective analysis of the patient's neutralizing antibodies found the neutralizing activity was low in the early stages of infection, but became high after recovery. This suggests the patient acquired an immunity to SARS-CoV-2 through the infection, despite having a mild myelosuppression due to treatment for recurrent breast cancer.Steroid pulse therapy is available worldwide, and may have an important role in cancer patients who develop severe pneumonia from SARS-CoV-2, by enabling them to avoid any long-term disruption to anticancer therapy. Moreover, it might also be useful when antiviral therapies lose their efficacy due to mutations of the virus, such as the Omicron variant. A critical element in cases such as this one is that treatment decisions are made by a team of specialists, including pulmonologists." @default.
- W4280493073 created "2022-05-22" @default.
- W4280493073 creator A5008356782 @default.
- W4280493073 creator A5039058444 @default.
- W4280493073 creator A5043360854 @default.
- W4280493073 creator A5067992113 @default.
- W4280493073 creator A5087059148 @default.
- W4280493073 creator A5087541425 @default.
- W4280493073 creator A5088569955 @default.
- W4280493073 date "2022-05-16" @default.
- W4280493073 modified "2023-09-26" @default.
- W4280493073 title "Successful treatment with steroid pulse therapy for a COVID-19 case with progressive respiratory failure during treatment for pleural metastasis of breast cancer" @default.
- W4280493073 cites W3005403371 @default.
- W4280493073 cites W3011610993 @default.
- W4280493073 cites W3012421327 @default.
- W4280493073 cites W3018098307 @default.
- W4280493073 cites W3094184862 @default.
- W4280493073 cites W3114776690 @default.
- W4280493073 cites W3120557430 @default.
- W4280493073 cites W4200112797 @default.
- W4280493073 doi "https://doi.org/10.1186/s40792-022-01451-4" @default.
- W4280493073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35576027" @default.
- W4280493073 hasPublicationYear "2022" @default.
- W4280493073 type Work @default.
- W4280493073 citedByCount "0" @default.
- W4280493073 crossrefType "journal-article" @default.
- W4280493073 hasAuthorship W4280493073A5008356782 @default.
- W4280493073 hasAuthorship W4280493073A5039058444 @default.
- W4280493073 hasAuthorship W4280493073A5043360854 @default.
- W4280493073 hasAuthorship W4280493073A5067992113 @default.
- W4280493073 hasAuthorship W4280493073A5087059148 @default.
- W4280493073 hasAuthorship W4280493073A5087541425 @default.
- W4280493073 hasAuthorship W4280493073A5088569955 @default.
- W4280493073 hasBestOaLocation W42804930731 @default.
- W4280493073 hasConcept C121608353 @default.
- W4280493073 hasConcept C126322002 @default.
- W4280493073 hasConcept C141071460 @default.
- W4280493073 hasConcept C2775930923 @default.
- W4280493073 hasConcept C2776256026 @default.
- W4280493073 hasConcept C2776888751 @default.
- W4280493073 hasConcept C2777914695 @default.
- W4280493073 hasConcept C2778311097 @default.
- W4280493073 hasConcept C2778978224 @default.
- W4280493073 hasConcept C2779634585 @default.
- W4280493073 hasConcept C2780372218 @default.
- W4280493073 hasConcept C2780401358 @default.
- W4280493073 hasConcept C530470458 @default.
- W4280493073 hasConcept C71924100 @default.
- W4280493073 hasConceptScore W4280493073C121608353 @default.
- W4280493073 hasConceptScore W4280493073C126322002 @default.
- W4280493073 hasConceptScore W4280493073C141071460 @default.
- W4280493073 hasConceptScore W4280493073C2775930923 @default.
- W4280493073 hasConceptScore W4280493073C2776256026 @default.
- W4280493073 hasConceptScore W4280493073C2776888751 @default.
- W4280493073 hasConceptScore W4280493073C2777914695 @default.
- W4280493073 hasConceptScore W4280493073C2778311097 @default.
- W4280493073 hasConceptScore W4280493073C2778978224 @default.
- W4280493073 hasConceptScore W4280493073C2779634585 @default.
- W4280493073 hasConceptScore W4280493073C2780372218 @default.
- W4280493073 hasConceptScore W4280493073C2780401358 @default.
- W4280493073 hasConceptScore W4280493073C530470458 @default.
- W4280493073 hasConceptScore W4280493073C71924100 @default.
- W4280493073 hasIssue "1" @default.
- W4280493073 hasLocation W42804930731 @default.
- W4280493073 hasLocation W42804930732 @default.
- W4280493073 hasLocation W42804930733 @default.
- W4280493073 hasOpenAccess W4280493073 @default.
- W4280493073 hasPrimaryLocation W42804930731 @default.
- W4280493073 hasRelatedWork W1921744819 @default.
- W4280493073 hasRelatedWork W2080448964 @default.
- W4280493073 hasRelatedWork W2356458657 @default.
- W4280493073 hasRelatedWork W2409312381 @default.
- W4280493073 hasRelatedWork W2415936443 @default.
- W4280493073 hasRelatedWork W2416009220 @default.
- W4280493073 hasRelatedWork W2560902288 @default.
- W4280493073 hasRelatedWork W4225142396 @default.
- W4280493073 hasRelatedWork W4235778269 @default.
- W4280493073 hasRelatedWork W4245293991 @default.
- W4280493073 hasVolume "8" @default.
- W4280493073 isParatext "false" @default.
- W4280493073 isRetracted "false" @default.
- W4280493073 workType "article" @default.