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- W4280493434 abstract "Cochlear implant (CI) infections affect a small, but significant number of patients. Unremitting infections can lead to explantation. Fluorescence in situ hybridization (FISH) and microbial community profiling (MCP) are methods of studying microbial environments of explanted devices that can provide information to reduce morbidity and costs of infected CIs.To describe the results and clinical significance of bacterial analyses conducted on explanted CIs.Between 2013 and 2017, 12 explanted devices underwent microbiological analysis in addition to the manufacturer's device failure analysis. Patients' clinical history, infection status and outcome were reviewed and correlated with microbial analysis results.From 2013 to 2017, 12 Cochlear™ devices from 11 patients underwent additional MCP or FISH analysis. Five devices were explanted due to suspected implant associated infection, and seven were explanted for other reasons. FISH analysis revealed biofilm presence on all infected devices, only partial correlation of cultures with biofilm composition and confirmation that biofilm formation occurs preferentially at particular device interfaces and geometries. MCP analysis presented challenges in data analysis inherent to its technique but correlated with cultures of infected devices and suggested a diverse microbial composition of explanted devices.Microbial analysis of explanted devices can aid in further elucidating treatment approaches to infected CIs." @default.
- W4280493434 created "2022-05-22" @default.
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- W4280493434 date "2022-05-12" @default.
- W4280493434 modified "2023-09-27" @default.
- W4280493434 title "Fluorescence <i>in situ</i> hybridization and microbial community profiling analysis of explanted cochlear implants" @default.
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- W4280493434 doi "https://doi.org/10.1080/00016489.2022.2070931" @default.
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