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• W4280493625 endingPage "6366" @default.
• W4280493625 startingPage "6342" @default.
• W4280493625 abstract "Streptococcus oralis is a member of the mitis group of oral streptococci and an early colonizer in dental plaque biofilm, a major cause of periodontal disease, dental caries, and other oral infections. S. oralis promotes biofilm growth by coaggregating in a mutualistic partnership with other early colonizers such as Actinomyces oris . For this cell‐to‐cell interaction, A. oris is known to use its sortase‐dependent pilus (type 2), but whether S. oralis uses its PI‐2 (pilus islet 2) pilus is still to be determined. The PI‐2 pilus is predicted to have a heterodimeric structure consisting of two different protein subunits with their own location and function: the tip PitA pilin for adhesion and the backbone PitB pilin for length. Thus far, structural information remains incomplete about the role of PI‐2 pili in the mutualistic mechanism between S. oralis and A. oris . We now report on the crystal structure analysis of PitA and PitB using X‐ray crystallography, small‐angle X‐ray scattering, and molecular docking studies. Accordingly, we propose a structural model for the PI‐2 pilus, wherein repeating PitB subunits are arranged head‐to‐tail to form the long backbone structure with PitA on the outer tip. By performing both in vitro and in vivo experiments, we examined the role played by PitA in mediating the mutualistic interaction between S. oralis and A. oris , which appears to involve the coaggregation factor CafA. We also reveal that the galactose monosaccharide is a conceivable ligand for PitA and thereby might be used to inhibit coaggregation and control oral biofilm development. Database Structural coordinates for the PitA fragment, PitA fragment TbXO4 derivative, full‐length PitA, and PitB from S. oralis have been deposited at the Protein Data Bank as 7VCR , 7W7I , 7VCN , 7W6B , and 7W7I , respectively. Streptococcus pneumoniae PitB coordinates have been deposited as 7F7Y ." @default.
• W4280493625 created "2022-05-22" @default.
• W4280493625 creator A5009570639 @default.
• W4280493625 creator A5050804116 @default.
• W4280493625 date "2022-05-28" @default.
• W4280493625 modified "2023-10-01" @default.
• W4280493625 title "New structural insights into the <scp>PI</scp>‐2 pilus from <i>Streptococcus oralis</i>, an early dental plaque colonizer" @default.
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