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• W4280493900 endingPage "1512" @default.
• W4280493900 startingPage "1501" @default.
• W4280493900 abstract "5-Fluorouracil (5-FU) is an antimetabolite drug used for over 70 years as first-line chemotherapy to treat various types of cancer, such as head, neck, breast, and colorectal cancer. 5-FU acts mainly by inhibiting thymidylate synthase, thereby interfering with deoxyribonucleic acid (DNA) replication or by 5-FU incorporating into DNA, causing damage to the sequence of nucleotides. Being analogous to uracil, 5-FU enters cells using the same transport mechanism, where a is converted into active metabolites such as fluorouridine triphosphate (FUTP), fluorodeoxyuridine monophosphate (FdUMP), and fluorodeoxyuridine triphosphate (FdUTP). Currently, there are several nano delivery systems being developed and evaluated at the preclinical level to overcome existing limitations to 5-FU chemotherapy, including liposomes, polymeric nanoparticles, polymeric micelles, nanoemulsions, mesoporous silica nanoparticles, and solid lipid nanoparticles. Therefore, it is essential to choose and develop suitable analytical methods for the quantification of 5-FU and its metabolites (5- fluorouridine and 5-fluoro-2-deoxyuridine) in pharmaceutical and biological samples. Among the analytical techniques, chromatographic methods are commonly the most used for the quantification of 5-FU from different matrices. However, other analytical methods have also been developed for the determination of 5-FU, such as electrochemical methods, a sensitive, selective, and precise technique, in addition to having a reduced cost. Here, we first review the physicochemical properties, mechanism of action, and advances in 5-FU nanodelivery systems. Next, we summarize the current progress of other chromatographic methods described to determine 5- FU. Lastly, we discuss the advantages of electrochemical methods for the identification and quantification of 5- FU and its metabolites in pharmaceutical and biological samples." @default.
• W4280493900 created "2022-05-22" @default.
• W4280493900 creator A5038211004 @default.
• W4280493900 creator A5056606353 @default.
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• W4280493900 creator A5086658739 @default.
• W4280493900 date "2022-05-01" @default.
• W4280493900 modified "2023-10-13" @default.
• W4280493900 title "An Updated Review on Properties, Nanodelivery Systems, and Analytical Methods for the Determination of 5-Fluorouracil in Pharmaceutical and Biological Samples" @default.
• W4280493900 cites W1142171728 @default.
• W4280493900 cites W1918793750 @default.
• W4280493900 cites W1977143275 @default.
• W4280493900 cites W1979996255 @default.
• W4280493900 cites W1984328540 @default.
• W4280493900 cites W1984651821 @default.
• W4280493900 cites W1986243162 @default.
• W4280493900 cites W1987838121 @default.
• W4280493900 cites W2000407555 @default.
• W4280493900 cites W2016437722 @default.
• W4280493900 cites W2026280713 @default.
• W4280493900 cites W2031769290 @default.
• W4280493900 cites W2065333692 @default.
• W4280493900 cites W2075304935 @default.
• W4280493900 cites W2132419347 @default.
• W4280493900 cites W2138926961 @default.
• W4280493900 cites W2139884756 @default.
• W4280493900 cites W2237834426 @default.
• W4280493900 cites W2282518039 @default.
• W4280493900 cites W2329459847 @default.
• W4280493900 cites W2339065698 @default.
• W4280493900 cites W2396699631 @default.
• W4280493900 cites W2416456107 @default.
• W4280493900 cites W2475139193 @default.
• W4280493900 cites W2593053298 @default.
• W4280493900 cites W2736493891 @default.
• W4280493900 cites W2743008942 @default.
• W4280493900 cites W2750612999 @default.
• W4280493900 cites W2752416314 @default.
• W4280493900 cites W2754991057 @default.
• W4280493900 cites W2771478918 @default.
• W4280493900 cites W2793372808 @default.
• W4280493900 cites W2807489698 @default.
• W4280493900 cites W2883264688 @default.
• W4280493900 cites W2886230235 @default.
• W4280493900 cites W2890711010 @default.
• W4280493900 cites W2898146268 @default.
• W4280493900 cites W2902708732 @default.
• W4280493900 cites W2913763297 @default.
• W4280493900 cites W2925177134 @default.
• W4280493900 cites W2940232083 @default.
• W4280493900 cites W2945689862 @default.
• W4280493900 cites W2966693474 @default.
• W4280493900 cites W2971030908 @default.
• W4280493900 cites W2982222521 @default.
• W4280493900 cites W2983343747 @default.
• W4280493900 cites W2990089967 @default.
• W4280493900 cites W3002390464 @default.
• W4280493900 cites W3015989356 @default.
• W4280493900 cites W3018012626 @default.
• W4280493900 cites W3023063277 @default.
• W4280493900 cites W3026155327 @default.
• W4280493900 cites W3033841889 @default.
• W4280493900 cites W3038726055 @default.
• W4280493900 cites W3039890648 @default.
• W4280493900 cites W3044147488 @default.
• W4280493900 cites W3045133764 @default.
• W4280493900 cites W3047510030 @default.
• W4280493900 cites W3083676239 @default.
• W4280493900 cites W3084354259 @default.
• W4280493900 cites W3089615670 @default.
• W4280493900 cites W3092623103 @default.
• W4280493900 cites W3093224011 @default.
• W4280493900 cites W3093695469 @default.
• W4280493900 cites W3095132827 @default.
• W4280493900 cites W3107032451 @default.
• W4280493900 cites W3109004303 @default.
• W4280493900 cites W3113257599 @default.
• W4280493900 cites W3118359366 @default.
• W4280493900 cites W3118583579 @default.
• W4280493900 cites W3122254526 @default.
• W4280493900 cites W3126322493 @default.
• W4280493900 cites W3131445273 @default.
• W4280493900 cites W3132606647 @default.
• W4280493900 cites W3132635904 @default.
• W4280493900 cites W3133754838 @default.
• W4280493900 cites W4213271665 @default.
• W4280493900 cites W4214777418 @default.
• W4280493900 cites W771030911 @default.
• W4280493900 doi "https://doi.org/10.2174/1381612828666220509150918" @default.
• W4280493900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35579160" @default.
• W4280493900 hasPublicationYear "2022" @default.
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