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- W4280494030 endingPage "459" @default.
- W4280494030 startingPage "459" @default.
- W4280494030 abstract "Depression is a significant cause of disability and affects millions worldwide; however, antidepressant therapies often fail or are inadequate. Current medications for treating major depressive disorder can take weeks or months to reach efficacy, have troubling side effects, and are limited in their long-term capabilities. Recent studies have identified a new set of glutamate-based approaches, such as blood glutamate scavengers, which have the potential to provide alternatives to traditional antidepressants. In this review, we hypothesize as to the involvement of the glutamate system in the development of depression. We identify the mechanisms underlying glutamate dysregulation, offering new perspectives on the therapeutic modalities of depression with a focus on its relationship to blood–brain barrier (BBB) permeability. Ultimately, we conclude that in diseases with impaired BBB permeability, such as depression following stroke or traumatic brain injury, or in neurogenerative diseases, the glutamate system should be considered as a pathway to treatment. We propose that drugs such as blood glutamate scavengers should be further studied for treatment of these conditions." @default.
- W4280494030 created "2022-05-22" @default.
- W4280494030 creator A5052353952 @default.
- W4280494030 creator A5070402908 @default.
- W4280494030 creator A5077056184 @default.
- W4280494030 creator A5077626899 @default.
- W4280494030 creator A5080255556 @default.
- W4280494030 date "2022-05-20" @default.
- W4280494030 modified "2023-09-25" @default.
- W4280494030 title "Glutamate Efflux across the Blood–Brain Barrier: New Perspectives on the Relationship between Depression and the Glutamatergic System" @default.
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