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• W4280494055 abstract "Introduction.Candida spp. are commensal fungal pathogens of humans, but when there is an imbalance in the microbiota, or weak host immunity, these yeasts can become pathogenic, generating high medical costs.Gap Statement. With the increase in resistance to conventional antifungals, the development of new therapeutic strategies is necessary. This study evaluated the in vitro antifungal activity of chlorogenic acid against fluconazole-resistant strains of Candida spp. Mechanism of action through flow cytometry and in silico analyses, as well as molecular docking assays with ALS3 and SAP5, important proteins in the pathogenesis of Candida albicans associated with the adhesion process and biofilm formation.Results. The chlorogenic acid showed in vitro antifungal activity against the strains tested, causing reduced cell viability, increased potential for mitochondrial depolarization and production of reactive oxygen species, DNA fragmentation and phosphatidylserine externalization, indicating an apoptotic process. Concerning the analysis through docking, the complexes formed between chlorogenic acid and the targets Thymidylate Kinase, CYP51, 1Yeast Cytochrome BC1 Complex e Exo-B-(1,3)-glucanase demonstrated more favourable binding energy. In addition, chlorogenic acid presented significant interactions with the ALS3 active site residues of C. albicans, important in the adhesion process and resistance to fluconazole. Regarding molecular docking with SAP5, no significant interactions were found between chlorogenic acid and the active site of the enzyme.Conclusion. We concluded that chlorogenic acid has potential use as an adjuvant in antifungal therapies, due to its anti-Candida activity and ability to interact with important drug targets." @default.
• W4280494055 created "2022-05-22" @default.
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• W4280494055 date "2022-05-16" @default.
• W4280494055 modified "2023-10-12" @default.
• W4280494055 title "Evaluation of the antifungal effect of chlorogenic acid against strains of Candida spp. resistant to fluconazole: apoptosis induction and in silico analysis of the possible mechanisms of action" @default.
• W4280494055 cites W1515096181 @default.
• W4280494055 cites W1517622624 @default.
• W4280494055 cites W1970579293 @default.
• W4280494055 cites W1980106726 @default.
• W4280494055 cites W1983588215 @default.
• W4280494055 cites W1991231077 @default.
• W4280494055 cites W1993538091 @default.
• W4280494055 cites W1995952752 @default.
• W4280494055 cites W2010920218 @default.
• W4280494055 cites W2018919826 @default.
• W4280494055 cites W2019208694 @default.
• W4280494055 cites W2022521911 @default.
• W4280494055 cites W2023194074 @default.
• W4280494055 cites W2027265770 @default.
• W4280494055 cites W2027633471 @default.
• W4280494055 cites W2028046413 @default.
• W4280494055 cites W2030876188 @default.
• W4280494055 cites W2039723884 @default.
• W4280494055 cites W2045895835 @default.
• W4280494055 cites W2050802002 @default.
• W4280494055 cites W2057549505 @default.
• W4280494055 cites W2064165014 @default.
• W4280494055 cites W2067631595 @default.
• W4280494055 cites W2067902357 @default.
• W4280494055 cites W2076547070 @default.
• W4280494055 cites W2094235329 @default.
• W4280494055 cites W2096570310 @default.
• W4280494055 cites W2102949118 @default.
• W4280494055 cites W2108985939 @default.
• W4280494055 cites W2109169263 @default.
• W4280494055 cites W2109962249 @default.
• W4280494055 cites W2110885004 @default.
• W4280494055 cites W2114509444 @default.
• W4280494055 cites W2119391289 @default.
• W4280494055 cites W2121853844 @default.
• W4280494055 cites W2132629607 @default.
• W4280494055 cites W2145486808 @default.
• W4280494055 cites W2146334001 @default.
• W4280494055 cites W2152529899 @default.
• W4280494055 cites W2152991606 @default.
• W4280494055 cites W2159969506 @default.
• W4280494055 cites W221552897 @default.
• W4280494055 cites W2315324126 @default.
• W4280494055 cites W2341662099 @default.
• W4280494055 cites W2395093176 @default.
• W4280494055 cites W2434970987 @default.
• W4280494055 cites W2513117848 @default.
• W4280494055 cites W2516760155 @default.
• W4280494055 cites W2516930919 @default.
• W4280494055 cites W2518966090 @default.
• W4280494055 cites W2567007177 @default.
• W4280494055 cites W2593598577 @default.
• W4280494055 cites W2608236623 @default.
• W4280494055 cites W2673333230 @default.
• W4280494055 cites W2737078696 @default.
• W4280494055 cites W2752023697 @default.
• W4280494055 cites W2767209834 @default.
• W4280494055 cites W2884983226 @default.
• W4280494055 cites W2885121248 @default.
• W4280494055 cites W2896553993 @default.
• W4280494055 cites W2904684911 @default.
• W4280494055 cites W2932341513 @default.
• W4280494055 cites W2938389706 @default.
• W4280494055 cites W2970096080 @default.
• W4280494055 cites W2982516671 @default.
• W4280494055 cites W3006910470 @default.
• W4280494055 cites W3008380512 @default.
• W4280494055 cites W3034028093 @default.
• W4280494055 cites W3040579901 @default.
• W4280494055 cites W3165564720 @default.
• W4280494055 cites W3197852135 @default.
• W4280494055 cites W4243719901 @default.
• W4280494055 cites W4375247832 @default.
• W4280494055 doi "https://doi.org/10.1099/jmm.0.001526" @default.
• W4280494055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35575783" @default.
• W4280494055 hasPublicationYear "2022" @default.
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