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• W4280494613 abstract "Group B streptococci (GBS) cause a range of invasive maternal–fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. GBS express a hyper-hemolytic ornithine rhamnolipid pigment toxin with cytolytic and coagulatory activity. Here, we investigated the effects of GBS pigment on human platelets. Infections of platelets with pigmented GBS resulted initially in platelet activation, followed by necrotic cell death. Thus, this study shows that GBS pigment kills human platelets." @default.
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• W4280494613 date "2022-05-13" @default.
• W4280494613 modified "2023-10-14" @default.
• W4280494613 title "Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process" @default.
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• W4280494613 doi "https://doi.org/10.3390/cells11101637" @default.
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