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- W4280494741 endingPage "989" @default.
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- W4280494741 abstract "Autologous whole cell vaccines use a patient's own tumor cells as a source of antigen to elicit an anti-tumor immune response in vivo. Recently, the authors conducted a systematic review of clinical trials employing these products in hematological cancers that showed a favorable safety profile and trend toward efficacy. However, it was noted that manufacturing challenges limit both the efficacy and clinical implementation of these vaccine products. In the current literature review, the authors sought to define the issues surrounding the manufacture of autologous whole cell products for hematological cancers. The authors describe key factors, including the acquisition, culture, cryopreservation and transduction of malignant cells, that require optimization for further advancement of the field. Furthermore, the authors provide a summary of pre-clinical work that informs how the identified challenges may be overcome. The authors also highlight areas in which future basic research would be of benefit to the field. The goal of this review is to provide a roadmap for investigators seeking to advance the field of autologous cell vaccines as it applies to hematological malignancies." @default.
- W4280494741 created "2022-05-22" @default.
- W4280494741 creator A5011868189 @default.
- W4280494741 creator A5044189126 @default.
- W4280494741 creator A5044307129 @default.
- W4280494741 creator A5078030826 @default.
- W4280494741 creator A5081199177 @default.
- W4280494741 date "2022-10-01" @default.
- W4280494741 modified "2023-09-26" @default.
- W4280494741 title "Current challenges in the manufacture of clinical-grade autologous whole cell vaccines for hematological malignancies" @default.
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