FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280494969> ?p ?o ?g. }

• W4280494969 endingPage "270" @default.
• W4280494969 startingPage "260" @default.
• W4280494969 abstract "Rationale: Constrictive bronchiolitis (ConB) is a relatively rare and understudied form of lung disease whose underlying immunopathology remains incompletely defined. Objectives: Our objectives were to quantify specific pathological features that differentiate ConB from other diseases that affect the small airways and to investigate the underlying immune and inflammatory phenotype present in ConB. Methods: We performed a comparative histomorphometric analysis of small airways in lung biopsy samples collected from 50 soldiers with postdeployment ConB, 8 patients with sporadic ConB, 55 patients with chronic obstructive pulmonary disease, and 25 nondiseased control subjects. We measured immune and inflammatory gene expression in lung tissue using the NanoString nCounter Immunology Panel from six control subjects, six soldiers with ConB, and six patients with sporadic ConB. Measurements and Main Results: Compared with control subjects, we found shared pathological changes in small airways from soldiers with postdeployment ConB and patients with sporadic ConB, including increased thickness of the smooth muscle layer, increased collagen deposition in the subepithelium, and lymphocyte infiltration. Using principal-component analysis, we showed that ConB pathology was clearly separable both from control lungs and from small airway disease associated with chronic obstructive pulmonary disease. NanoString gene expression analysis from lung tissue revealed T-cell activation in both groups of patients with ConB with upregulation of proinflammatory pathways, including cytokine-cytokine receptor interactions, NF-κB (nuclear factor-κB) signaling, TLR (Toll-like receptor) signaling, T-cell receptor signaling, and antigen processing and presentation. Conclusions: These findings indicate shared immunopathology among different forms of ConB and suggest that an ongoing T-helper cell type 1-type adaptive immune response underlies airway wall remodeling in ConB." @default.
• W4280494969 created "2022-05-22" @default.
• W4280494969 creator A5000589846 @default.
• W4280494969 creator A5003270601 @default.
• W4280494969 creator A5017239424 @default.
• W4280494969 creator A5017253129 @default.
• W4280494969 creator A5019489957 @default.
• W4280494969 creator A5060874168 @default.
• W4280494969 creator A5063872240 @default.
• W4280494969 creator A5066291455 @default.
• W4280494969 creator A5073164506 @default.
• W4280494969 creator A5074717453 @default.
• W4280494969 creator A5075023441 @default.
• W4280494969 creator A5080593446 @default.
• W4280494969 creator A5083270547 @default.
• W4280494969 creator A5090645846 @default.
• W4280494969 date "2022-08-01" @default.
• W4280494969 modified "2023-10-14" @default.
• W4280494969 title "Characterization of Immunopathology and Small Airway Remodeling in Constrictive Bronchiolitis" @default.
• W4280494969 cites W12802298 @default.
• W4280494969 cites W1879350046 @default.
• W4280494969 cites W1936558621 @default.
• W4280494969 cites W1963492502 @default.
• W4280494969 cites W1965890661 @default.
• W4280494969 cites W1972194330 @default.
• W4280494969 cites W1987368485 @default.
• W4280494969 cites W1990993746 @default.
• W4280494969 cites W1995995891 @default.
• W4280494969 cites W2010101251 @default.
• W4280494969 cites W2011287628 @default.
• W4280494969 cites W2023642966 @default.
• W4280494969 cites W2036788379 @default.
• W4280494969 cites W2051089409 @default.
• W4280494969 cites W2066673998 @default.
• W4280494969 cites W2080853084 @default.
• W4280494969 cites W2081653064 @default.
• W4280494969 cites W2087317743 @default.
• W4280494969 cites W2096026559 @default.
• W4280494969 cites W2098053759 @default.
• W4280494969 cites W2101253529 @default.
• W4280494969 cites W2114442951 @default.
• W4280494969 cites W2119479403 @default.
• W4280494969 cites W2135430305 @default.
• W4280494969 cites W2143265118 @default.
• W4280494969 cites W2148739171 @default.
• W4280494969 cites W2158384363 @default.
• W4280494969 cites W2166780150 @default.
• W4280494969 cites W2168083744 @default.
• W4280494969 cites W2180134488 @default.
• W4280494969 cites W2208460282 @default.
• W4280494969 cites W2291788546 @default.
• W4280494969 cites W2320023378 @default.
• W4280494969 cites W2327680946 @default.
• W4280494969 cites W2333662256 @default.
• W4280494969 cites W2395414551 @default.
• W4280494969 cites W2416539102 @default.
• W4280494969 cites W2460245557 @default.
• W4280494969 cites W2472315283 @default.
• W4280494969 cites W2757732457 @default.
• W4280494969 cites W2808327894 @default.
• W4280494969 cites W2886480783 @default.
• W4280494969 cites W2910369454 @default.
• W4280494969 cites W2940115647 @default.
• W4280494969 cites W2952406594 @default.
• W4280494969 cites W2964416832 @default.
• W4280494969 cites W3007778566 @default.
• W4280494969 cites W3021480273 @default.
• W4280494969 cites W3023117791 @default.
• W4280494969 cites W3095119438 @default.
• W4280494969 cites W3124909525 @default.
• W4280494969 cites W3150132548 @default.
• W4280494969 cites W3165130929 @default.
• W4280494969 cites W4238367411 @default.
• W4280494969 cites W4238650021 @default.
• W4280494969 cites W4280494969 @default.
• W4280494969 doi "https://doi.org/10.1164/rccm.202109-2133oc" @default.
• W4280494969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35550018" @default.
• W4280494969 hasPublicationYear "2022" @default.
• W4280494969 type Work @default.
• W4280494969 citedByCount "11" @default.
• W4280494969 countsByYear W42804949692022 @default.
• W4280494969 countsByYear W42804949692023 @default.
• W4280494969 crossrefType "journal-article" @default.
• W4280494969 hasAuthorship W4280494969A5000589846 @default.
• W4280494969 hasAuthorship W4280494969A5003270601 @default.
• W4280494969 hasAuthorship W4280494969A5017239424 @default.
• W4280494969 hasAuthorship W4280494969A5017253129 @default.
• W4280494969 hasAuthorship W4280494969A5019489957 @default.
• W4280494969 hasAuthorship W4280494969A5060874168 @default.
• W4280494969 hasAuthorship W4280494969A5063872240 @default.
• W4280494969 hasAuthorship W4280494969A5066291455 @default.
• W4280494969 hasAuthorship W4280494969A5073164506 @default.
• W4280494969 hasAuthorship W4280494969A5074717453 @default.
• W4280494969 hasAuthorship W4280494969A5075023441 @default.
• W4280494969 hasAuthorship W4280494969A5080593446 @default.
• W4280494969 hasAuthorship W4280494969A5083270547 @default.
• W4280494969 hasAuthorship W4280494969A5090645846 @default.
• W4280494969 hasBestOaLocation W42804949692 @default.

• next