Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280495012> ?p ?o ?g. }
- W4280495012 abstract "Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson’s disease (PD) is connected with mitochondrial neuronal damage related to mitochondrial unfolded protein response (mtUPR). Rosmarinic acid (RA) is a naturally occurring hydroxylated polyphenolic chemical found in the Boraginaceae and the Labiatae subfamily Nepetoideae. This study looked into RA’s protective effect against mitochondrial loss in the substantia nigra (SN) caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the underlying mechanism associated with the mtUPR. Pretreatment with RA reduced motor impairments and dopaminergic neuronal degeneration in the SN of a mouse model injected with MPTP. Pretreatment of SH-SY5Y cells from cell viability loss, morphological damage, and oxidative stress. Furthermore, RA pre-injection suppressed MPTP-induced mtUPR, lowered the expression of HSPA9, HSPE1, CLPP, LONP1, and SIRT 4, and protected the MPTP-mice and SH-SY5Y cells from mitochondrial failure. These findings imply that RA can prevent Parkinson’s disease by preventing mitochondrial damage in dopaminergic neurons in Parkinson’s disease via alleviating mitochondrial unfolded protein response." @default.
- W4280495012 created "2022-05-22" @default.
- W4280495012 creator A5002095872 @default.
- W4280495012 creator A5006656608 @default.
- W4280495012 creator A5008239342 @default.
- W4280495012 creator A5018682614 @default.
- W4280495012 creator A5019404404 @default.
- W4280495012 creator A5027255941 @default.
- W4280495012 creator A5041576507 @default.
- W4280495012 creator A5050132415 @default.
- W4280495012 creator A5065301345 @default.
- W4280495012 creator A5071090304 @default.
- W4280495012 creator A5079674609 @default.
- W4280495012 date "2022-05-16" @default.
- W4280495012 modified "2023-10-02" @default.
- W4280495012 title "Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response" @default.
- W4280495012 cites W1631437471 @default.
- W4280495012 cites W1973089795 @default.
- W4280495012 cites W1988560967 @default.
- W4280495012 cites W2037206515 @default.
- W4280495012 cites W2045051842 @default.
- W4280495012 cites W2064966129 @default.
- W4280495012 cites W2085841572 @default.
- W4280495012 cites W2088318694 @default.
- W4280495012 cites W2090968629 @default.
- W4280495012 cites W2094939646 @default.
- W4280495012 cites W2137289528 @default.
- W4280495012 cites W2143550648 @default.
- W4280495012 cites W2155118287 @default.
- W4280495012 cites W2199406275 @default.
- W4280495012 cites W2563900680 @default.
- W4280495012 cites W2589784135 @default.
- W4280495012 cites W2592024720 @default.
- W4280495012 cites W2645489726 @default.
- W4280495012 cites W2692479174 @default.
- W4280495012 cites W2733537351 @default.
- W4280495012 cites W2751672023 @default.
- W4280495012 cites W2765808474 @default.
- W4280495012 cites W2783523925 @default.
- W4280495012 cites W2895181790 @default.
- W4280495012 cites W2897992965 @default.
- W4280495012 cites W2911440896 @default.
- W4280495012 cites W2921106634 @default.
- W4280495012 cites W2922137764 @default.
- W4280495012 cites W2937362047 @default.
- W4280495012 cites W2969573657 @default.
- W4280495012 cites W2977367243 @default.
- W4280495012 cites W2981894155 @default.
- W4280495012 cites W2993703207 @default.
- W4280495012 cites W2995996772 @default.
- W4280495012 cites W2999145612 @default.
- W4280495012 cites W3001591940 @default.
- W4280495012 cites W3011652524 @default.
- W4280495012 cites W3016859423 @default.
- W4280495012 cites W3035472586 @default.
- W4280495012 cites W3037543066 @default.
- W4280495012 cites W3043167844 @default.
- W4280495012 cites W3085381257 @default.
- W4280495012 cites W3111927179 @default.
- W4280495012 cites W4211044101 @default.
- W4280495012 cites W785786905 @default.
- W4280495012 doi "https://doi.org/10.3389/fphar.2022.859978" @default.
- W4280495012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35652041" @default.
- W4280495012 hasPublicationYear "2022" @default.
- W4280495012 type Work @default.
- W4280495012 citedByCount "5" @default.
- W4280495012 countsByYear W42804950122022 @default.
- W4280495012 countsByYear W42804950122023 @default.
- W4280495012 crossrefType "journal-article" @default.
- W4280495012 hasAuthorship W4280495012A5002095872 @default.
- W4280495012 hasAuthorship W4280495012A5006656608 @default.
- W4280495012 hasAuthorship W4280495012A5008239342 @default.
- W4280495012 hasAuthorship W4280495012A5018682614 @default.
- W4280495012 hasAuthorship W4280495012A5019404404 @default.
- W4280495012 hasAuthorship W4280495012A5027255941 @default.
- W4280495012 hasAuthorship W4280495012A5041576507 @default.
- W4280495012 hasAuthorship W4280495012A5050132415 @default.
- W4280495012 hasAuthorship W4280495012A5065301345 @default.
- W4280495012 hasAuthorship W4280495012A5071090304 @default.
- W4280495012 hasAuthorship W4280495012A5079674609 @default.
- W4280495012 hasBestOaLocation W42804950121 @default.
- W4280495012 hasConcept C13591479 @default.
- W4280495012 hasConcept C137183658 @default.
- W4280495012 hasConcept C139447449 @default.
- W4280495012 hasConcept C169760540 @default.
- W4280495012 hasConcept C190283241 @default.
- W4280495012 hasConcept C2776151105 @default.
- W4280495012 hasConcept C2778674702 @default.
- W4280495012 hasConcept C2780938664 @default.
- W4280495012 hasConcept C28859421 @default.
- W4280495012 hasConcept C31573885 @default.
- W4280495012 hasConcept C513476851 @default.
- W4280495012 hasConcept C55493867 @default.
- W4280495012 hasConcept C86803240 @default.
- W4280495012 hasConcept C95444343 @default.
- W4280495012 hasConceptScore W4280495012C13591479 @default.
- W4280495012 hasConceptScore W4280495012C137183658 @default.
- W4280495012 hasConceptScore W4280495012C139447449 @default.
- W4280495012 hasConceptScore W4280495012C169760540 @default.
- W4280495012 hasConceptScore W4280495012C190283241 @default.