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• W4280495057 abstract "Abstract Adaptive introgression (AI) facilitates local adaptation in a wide range of species. Many state-of-the-art methods detect AI with ad-hoc approaches that identify summary statistic outliers or intersect scans for positive selection with scans for introgressed genomic regions. Although widely used, these outlier-based approaches are vulnerable to a high false-negative rate as the power of different methods vary, especially for complex introgression events. Moreover, population genetic processes unrelated to AI, such as background selection or heterosis, may create similar genomic signals as AI, compromising the reliability of methods that rely on neutral null distributions. In recent years, machine learning (ML) methods have been increasingly applied to population genetic questions. Here, we present an ML-based method called MaLAdapt for identifying AI loci from genome-wide sequencing data. Using an Extra-Trees Classifier algorithm, our method combines information from a large number of biologically meaningful summary statistics to capture a powerful composite signature of AI across the genome. In contrast to existing methods, MaLAdapt is especially well-powered to detect AI with mild beneficial effects, including selection on standing archaic variation, and is robust to non-AI selection sweeps, heterosis, and demographic misspecifications. Further, MaLAdapt outperforms existing methods for detecting AI based on the analysis of simulated data and on a validation of empirical signals through visual impaction of haplotype patterns. We apply MaLAdapt to the 1000 Genomes Project human genomic data, and discover novel AI candidate regions in non-African populations, including genes that are enriched in functionally important biological pathways regulating metabolism and immune responses." @default.
• W4280495057 created "2022-05-22" @default.
• W4280495057 creator A5022201759 @default.
• W4280495057 creator A5049741676 @default.
• W4280495057 creator A5051535161 @default.
• W4280495057 creator A5053468208 @default.
• W4280495057 creator A5060409004 @default.
• W4280495057 creator A5066467126 @default.
• W4280495057 date "2022-05-17" @default.
• W4280495057 modified "2023-09-26" @default.
• W4280495057 title "<i>MaLAdapt</i> reveals novel targets of adaptive introgression from Neanderthals and Denisovans in worldwide human populations" @default.
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