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- W4280495059 abstract "Acute alcohol administration affects functional connectivity, yet the underlying mechanism is unknown. Previous work suggested that a moderate dose of alcohol reduces the activity of gamma-aminobutyric acidergic (GABAergic) interneurons, thereby leading to a state of pyramidal disinhibition and hyperexcitability. The present study aims to relate alcohol-induced changes in functional connectivity to regional genetic markers of GABAergic interneurons. Healthy young adults (N = 15, 5 males) underwent resting state functional MRI scanning prior to alcohol administration, immediately and 90 min after alcohol administration. Functional connectivity density mapping was performed to quantify alcohol-induced changes in resting brain activity between conditions. Patterns of differences between conditions were related to regional genetic markers that express the primary GABAergic cortical interneuron subtypes (parvalbumin, somatostatin, and 5-hydroxytryptamine receptor 3A) obtained from the Allen Human Brain Atlas. Acute alcohol administration increased local functional connectivity density within the visual cortex, sensorimotor cortex, thalamus, striatum, and cerebellum. Patterns of alcohol-induced changes in local functional connectivity density inversely correlated with somatostatin cortical gene expression. These findings suggest that somatostatin-expressing interneurons modulate alcohol-induced changes in functional connectivity in healthy individuals." @default.
- W4280495059 created "2022-05-22" @default.
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- W4280495059 date "2022-05-12" @default.
- W4280495059 modified "2023-10-05" @default.
- W4280495059 title "Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex" @default.
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- W4280495059 cites W1988581447 @default.
- W4280495059 cites W1990621985 @default.
- W4280495059 cites W1992465429 @default.
- W4280495059 cites W2007318901 @default.
- W4280495059 cites W2007729962 @default.
- W4280495059 cites W2014768392 @default.
- W4280495059 cites W2016731192 @default.
- W4280495059 cites W2025987292 @default.
- W4280495059 cites W2050074798 @default.
- W4280495059 cites W2055655674 @default.
- W4280495059 cites W2062398979 @default.
- W4280495059 cites W2063218710 @default.
- W4280495059 cites W2064205606 @default.
- W4280495059 cites W2067456724 @default.
- W4280495059 cites W2072233996 @default.
- W4280495059 cites W2107177274 @default.
- W4280495059 cites W2109061387 @default.
- W4280495059 cites W2113619522 @default.
- W4280495059 cites W2123055367 @default.
- W4280495059 cites W2127564371 @default.
- W4280495059 cites W2130705458 @default.
- W4280495059 cites W2135192074 @default.
- W4280495059 cites W2144213527 @default.
- W4280495059 cites W2156925439 @default.
- W4280495059 cites W2159570624 @default.
- W4280495059 cites W2328530108 @default.
- W4280495059 cites W2394842952 @default.
- W4280495059 cites W2412366109 @default.
- W4280495059 cites W2503929286 @default.
- W4280495059 cites W2536956629 @default.
- W4280495059 cites W2541740194 @default.
- W4280495059 cites W2574897276 @default.
- W4280495059 cites W2597348720 @default.
- W4280495059 cites W2743788602 @default.
- W4280495059 cites W2779115478 @default.
- W4280495059 cites W2791194758 @default.
- W4280495059 cites W2791606760 @default.
- W4280495059 cites W2797702265 @default.
- W4280495059 cites W2885824276 @default.
- W4280495059 cites W2897384574 @default.
- W4280495059 cites W2900516349 @default.
- W4280495059 cites W2906911338 @default.
- W4280495059 cites W2911724176 @default.
- W4280495059 cites W2950564037 @default.
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- W4280495059 cites W2952215064 @default.
- W4280495059 cites W2953090092 @default.
- W4280495059 cites W2953211102 @default.
- W4280495059 cites W2999279320 @default.
- W4280495059 cites W3024175336 @default.
- W4280495059 cites W3036199858 @default.
- W4280495059 cites W3043111681 @default.
- W4280495059 cites W3091722552 @default.
- W4280495059 cites W3097263943 @default.
- W4280495059 cites W3112433463 @default.
- W4280495059 cites W3117425451 @default.
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- W4280495059 cites W3172099106 @default.
- W4280495059 cites W3182085149 @default.
- W4280495059 cites W3208852943 @default.
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- W4280495059 doi "https://doi.org/10.1038/s41598-022-12035-5" @default.
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- W4280495059 hasPublicationYear "2022" @default.
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