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- W4280495660 abstract "Abstract Background: Accurate staging of non-small cell lung cancer is key in treatment planning and prediction of prognosis. We investigated the correlation between the maximum standardized uptake value (SUVmax) retention index (RI) of the primary tumor and lymph node metastasis in non-small cell lung carcinoma. We also evaluated the tendencies according to the histological types. Methods : We retrospectively evaluated 218 non-small cell lung cancer (NSCLC) tumors from 217 patients who underwent pre-operative fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) followed by lung surgery and lymph node resection between July 2015 and August 2020. All primary tumors were calculated as the SUVmax at 50 min (SUVmax early [SUVmax e ]) and 120 min (SUVmax delayed [SUVmax d ]), and RI. The clinico-pathological factors of interest were compared based on lymph node metastasis status and NSCLC histo-pathological subtype. Results: The median SUVmax e and SUVmax d of the primary tumor were 3.3 and 4.2, respectively, and the median RI was 0.25. The RI was significantly higher in the pN(+) (n = 44) group (0.30) compared to the pN0 (n = 174) group (0.24) (p = 0.01). In patients with adenocarcinoma (n = 145), the RI was also significantly higher in the pN(+) (n = 29) group (0.29) compared to the pN0 (n = 116) group (0.16) (p <0.01). A high RI of the primary tumor was an independent risk factor for lymph node metastasis, particularly in patients with adenocarcinoma (odds ratio: 12.30, p <0.05). Conclusions: The RI of primary NSCLC tumors can help predict lymph node metastases, particularly in patients with adenocarcinoma." @default.
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- W4280495660 date "2022-05-13" @default.
- W4280495660 modified "2023-10-16" @default.
- W4280495660 title "Retention index of FDG-PET/CT SUVmax of the primary tumor in non-small cell lung cancer as a predictor of lymph node metastasis: a retrospective study" @default.
- W4280495660 doi "https://doi.org/10.21203/rs.3.rs-1623907/v1" @default.
- W4280495660 hasPublicationYear "2022" @default.
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