Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280495736> ?p ?o ?g. }
- W4280495736 abstract "Abstract Background With the rising number of chimeric antigen receptor (CAR) T cell treated patients, it is increasingly important to understand the treatment’s impact on patient-reported outcomes (PROs) and, ideally, identify biomarkers of central nervous system (CNS) adverse effects. Methods The purpose of this exploratory study was to assess short-term PROs and serum kynurenine metabolites for associated neurotoxicity among patients treated in an anti-CD20, anti-CD19 (LV20.19) CAR T cell phase I clinical trial (NCT03019055). Fifteen CAR T treated patients from the parent trial provided serum samples and self-report surveys 15 days before and 14, 28, and 90 days after treatment. Results Blood kynurenine concentrations increased over time in patients with evidence of neurotoxicity ( p = 0.004) and were increased in self-reported depression ( r = 0.52, p = 0.002). Depression improved after CAR T infusion ( p = 0.035). Elevated 3-hydroxyanthranilic acid (3HAA) concentrations prior to cell infusion were also predictive of neurotoxicity onset ( p = 0.031), suggesting it is a biomarker of neurotoxicity following CAR T cell therapy. Conclusions Elevated levels of kynurenine pathway metabolites among CAR T cell recipients are associated with depressed mood and neurotoxicity. Findings from this exploratory study are preliminary and warrant validation in a larger cohort." @default.
- W4280495736 created "2022-05-22" @default.
- W4280495736 creator A5003913525 @default.
- W4280495736 creator A5004234559 @default.
- W4280495736 creator A5004672963 @default.
- W4280495736 creator A5008386945 @default.
- W4280495736 creator A5011136538 @default.
- W4280495736 creator A5017709460 @default.
- W4280495736 creator A5022627454 @default.
- W4280495736 creator A5024691172 @default.
- W4280495736 creator A5044298810 @default.
- W4280495736 creator A5046960770 @default.
- W4280495736 creator A5058978596 @default.
- W4280495736 creator A5066274721 @default.
- W4280495736 creator A5073507148 @default.
- W4280495736 creator A5077602611 @default.
- W4280495736 creator A5085201883 @default.
- W4280495736 creator A5088341793 @default.
- W4280495736 date "2022-05-12" @default.
- W4280495736 modified "2023-10-06" @default.
- W4280495736 title "Patient-reported outcomes and neurotoxicity markers in patients treated with bispecific LV20.19 CAR T cell therapy" @default.
- W4280495736 cites W1521227887 @default.
- W4280495736 cites W1566293442 @default.
- W4280495736 cites W1985438873 @default.
- W4280495736 cites W1993120818 @default.
- W4280495736 cites W1998878650 @default.
- W4280495736 cites W2002250647 @default.
- W4280495736 cites W2003982930 @default.
- W4280495736 cites W2004243143 @default.
- W4280495736 cites W2004347369 @default.
- W4280495736 cites W2020142342 @default.
- W4280495736 cites W2044335332 @default.
- W4280495736 cites W2049344284 @default.
- W4280495736 cites W2050951274 @default.
- W4280495736 cites W2052285428 @default.
- W4280495736 cites W2068992432 @default.
- W4280495736 cites W2072016770 @default.
- W4280495736 cites W2080519347 @default.
- W4280495736 cites W2082708772 @default.
- W4280495736 cites W2098443706 @default.
- W4280495736 cites W2103997793 @default.
- W4280495736 cites W2107448235 @default.
- W4280495736 cites W2109668208 @default.
- W4280495736 cites W2144269761 @default.
- W4280495736 cites W2169942357 @default.
- W4280495736 cites W2316408204 @default.
- W4280495736 cites W2320909684 @default.
- W4280495736 cites W2408097265 @default.
- W4280495736 cites W2537037927 @default.
- W4280495736 cites W2573622497 @default.
- W4280495736 cites W2608386405 @default.
- W4280495736 cites W2619933220 @default.
- W4280495736 cites W2736208466 @default.
- W4280495736 cites W2741302852 @default.
- W4280495736 cites W2754562068 @default.
- W4280495736 cites W2768606713 @default.
- W4280495736 cites W2781944731 @default.
- W4280495736 cites W2788008397 @default.
- W4280495736 cites W2805860820 @default.
- W4280495736 cites W2884815064 @default.
- W4280495736 cites W2887449433 @default.
- W4280495736 cites W2889858763 @default.
- W4280495736 cites W2891543209 @default.
- W4280495736 cites W2902598369 @default.
- W4280495736 cites W2903062212 @default.
- W4280495736 cites W2905654445 @default.
- W4280495736 cites W2912785417 @default.
- W4280495736 cites W2917676884 @default.
- W4280495736 cites W2938308258 @default.
- W4280495736 cites W2944998775 @default.
- W4280495736 cites W2952842269 @default.
- W4280495736 cites W2955607598 @default.
- W4280495736 cites W2979947027 @default.
- W4280495736 cites W2984009616 @default.
- W4280495736 cites W3007507981 @default.
- W4280495736 cites W3046970450 @default.
- W4280495736 cites W3087057425 @default.
- W4280495736 cites W3089727781 @default.
- W4280495736 cites W3095173757 @default.
- W4280495736 cites W3119335258 @default.
- W4280495736 cites W3169798438 @default.
- W4280495736 cites W3210455246 @default.
- W4280495736 cites W4250329983 @default.
- W4280495736 doi "https://doi.org/10.1038/s43856-022-00116-5" @default.
- W4280495736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36372801" @default.
- W4280495736 hasPublicationYear "2022" @default.
- W4280495736 type Work @default.
- W4280495736 citedByCount "4" @default.
- W4280495736 countsByYear W42804957362022 @default.
- W4280495736 countsByYear W42804957362023 @default.
- W4280495736 crossrefType "journal-article" @default.
- W4280495736 hasAuthorship W4280495736A5003913525 @default.
- W4280495736 hasAuthorship W4280495736A5004234559 @default.
- W4280495736 hasAuthorship W4280495736A5004672963 @default.
- W4280495736 hasAuthorship W4280495736A5008386945 @default.
- W4280495736 hasAuthorship W4280495736A5011136538 @default.
- W4280495736 hasAuthorship W4280495736A5017709460 @default.
- W4280495736 hasAuthorship W4280495736A5022627454 @default.
- W4280495736 hasAuthorship W4280495736A5024691172 @default.
- W4280495736 hasAuthorship W4280495736A5044298810 @default.