FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280496003> ?p ?o ?g. }

• W4280496003 endingPage "901" @default.
• W4280496003 startingPage "888" @default.
• W4280496003 abstract "Background and Aims: In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs). However, the pathogenic mechanisms that trigger HSC activation in leptin‐deficient obesity are still unknown. This study aimed to determine how HSC‐targeting lipocalin‐2 (LCN2) mediates the transition from simple steatosis to NASH. Approach and Results: Male wild‐type (WT) and ob/ob mice were fed a high‐fat diet (HFD) for 20 weeks to establish an animal model of NASH with fibrosis. Ob/ob mice were subject to caloric restriction or recombinant leptin treatment. Double knockout (DKO) mice lacking both leptin and lcn2 were also fed an HFD for 20 weeks. In addition, HFD‐fed ob/ob mice were treated with gadolinium trichloride to deplete Kupffer cells. The LX‐2 human HSCs and primary HSCs from ob/ob mice were used to investigate the effects of LCN2 on HSC activation. Serum and hepatic LCN2 expression levels were prominently increased in HFD‐fed ob/ob mice compared with normal diet‐fed ob/ob mice or HFD‐fed WT mice, and these changes were closely linked to liver fibrosis and increased hepatic α‐SMA/matrix metalloproteinase 9 (MMP9)/signal transducer and activator of transcription 3 (STAT3) protein levels. HFD‐fed DKO mice showed a marked reduction of α‐SMA protein compared with HFD‐fed ob/ob mice. In particular, the colocalization of LCN2 and α‐SMA was increased in HSCs from HFD‐fed ob/ob mice. In primary HSCs from ob/ob mice, exogenous LCN2 treatment induced HSC activation and MMP9 secretion. By contrast, LCN2 receptor 24p3R deficiency or a STAT3 inhibitor reduced the activation and migration of primary HSCs. Conclusions: LCN2 acts as a key mediator of HSC activation in leptin‐deficient obesity via α‐SMA/MMP9/STAT3 signaling, thereby exacerbating NASH." @default.
• W4280496003 created "2022-05-22" @default.
• W4280496003 creator A5002111948 @default.
• W4280496003 creator A5013163283 @default.
• W4280496003 creator A5031427464 @default.
• W4280496003 creator A5036921085 @default.
• W4280496003 creator A5043016321 @default.
• W4280496003 creator A5052579601 @default.
• W4280496003 creator A5057367224 @default.
• W4280496003 creator A5067690003 @default.
• W4280496003 creator A5072719950 @default.
• W4280496003 creator A5074311299 @default.
• W4280496003 creator A5077525271 @default.
• W4280496003 creator A5089043298 @default.
• W4280496003 creator A5089456278 @default.
• W4280496003 date "2023-02-17" @default.
• W4280496003 modified "2023-10-14" @default.
• W4280496003 title "Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice" @default.
• W4280496003 cites W125326510 @default.
• W4280496003 cites W1588950918 @default.
• W4280496003 cites W1965636244 @default.
• W4280496003 cites W1974144714 @default.
• W4280496003 cites W1979986306 @default.
• W4280496003 cites W1985575617 @default.
• W4280496003 cites W1988830658 @default.
• W4280496003 cites W1989787732 @default.
• W4280496003 cites W1992006494 @default.
• W4280496003 cites W1999438839 @default.
• W4280496003 cites W2001480291 @default.
• W4280496003 cites W2002733746 @default.
• W4280496003 cites W2023044058 @default.
• W4280496003 cites W2042694297 @default.
• W4280496003 cites W2045224428 @default.
• W4280496003 cites W2077508723 @default.
• W4280496003 cites W2077981997 @default.
• W4280496003 cites W2088579638 @default.
• W4280496003 cites W2094112735 @default.
• W4280496003 cites W2104193042 @default.
• W4280496003 cites W2122044177 @default.
• W4280496003 cites W2144199622 @default.
• W4280496003 cites W2147624501 @default.
• W4280496003 cites W2148878254 @default.
• W4280496003 cites W2161085345 @default.
• W4280496003 cites W2162382402 @default.
• W4280496003 cites W2170164215 @default.
• W4280496003 cites W2171671091 @default.
• W4280496003 cites W2291913215 @default.
• W4280496003 cites W2345356447 @default.
• W4280496003 cites W2411115932 @default.
• W4280496003 cites W2469365710 @default.
• W4280496003 cites W2589117823 @default.
• W4280496003 cites W2613180696 @default.
• W4280496003 cites W2734724639 @default.
• W4280496003 cites W2793435344 @default.
• W4280496003 cites W2796501734 @default.
• W4280496003 cites W2806943561 @default.
• W4280496003 cites W2810423511 @default.
• W4280496003 cites W2892273868 @default.
• W4280496003 cites W2913576444 @default.
• W4280496003 cites W2938768157 @default.
• W4280496003 cites W3005214954 @default.
• W4280496003 cites W3027786205 @default.
• W4280496003 cites W3110189951 @default.
• W4280496003 doi "https://doi.org/10.1002/hep.32569" @default.
• W4280496003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35560370" @default.
• W4280496003 hasPublicationYear "2023" @default.
• W4280496003 type Work @default.
• W4280496003 citedByCount "13" @default.
• W4280496003 countsByYear W42804960032022 @default.
• W4280496003 countsByYear W42804960032023 @default.
• W4280496003 crossrefType "journal-article" @default.
• W4280496003 hasAuthorship W4280496003A5002111948 @default.
• W4280496003 hasAuthorship W4280496003A5013163283 @default.
• W4280496003 hasAuthorship W4280496003A5031427464 @default.
• W4280496003 hasAuthorship W4280496003A5036921085 @default.
• W4280496003 hasAuthorship W4280496003A5043016321 @default.
• W4280496003 hasAuthorship W4280496003A5052579601 @default.
• W4280496003 hasAuthorship W4280496003A5057367224 @default.
• W4280496003 hasAuthorship W4280496003A5067690003 @default.
• W4280496003 hasAuthorship W4280496003A5072719950 @default.
• W4280496003 hasAuthorship W4280496003A5074311299 @default.
• W4280496003 hasAuthorship W4280496003A5077525271 @default.
• W4280496003 hasAuthorship W4280496003A5089043298 @default.
• W4280496003 hasAuthorship W4280496003A5089456278 @default.
• W4280496003 hasBestOaLocation W42804960031 @default.
• W4280496003 hasConcept C126322002 @default.
• W4280496003 hasConcept C134018914 @default.
• W4280496003 hasConcept C171089720 @default.
• W4280496003 hasConcept C176891718 @default.
• W4280496003 hasConcept C185592680 @default.
• W4280496003 hasConcept C20299238 @default.
• W4280496003 hasConcept C2776175330 @default.
• W4280496003 hasConcept C2776782570 @default.
• W4280496003 hasConcept C2776954865 @default.
• W4280496003 hasConcept C2777391703 @default.
• W4280496003 hasConcept C2778772119 @default.
• W4280496003 hasConcept C2779134260 @default.
• W4280496003 hasConcept C2779306644 @default.

• next