Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280496553> ?p ?o ?g. }
- W4280496553 endingPage "155872" @default.
- W4280496553 startingPage "155872" @default.
- W4280496553 abstract "Coastal areas are worldwide subject to large inputs of anthropogenic wastes that are discharged directly into inshore waters, where they will be weathered into small microplastics (MPs) of up to a size <20 μm. This study provides information about the presence of small environmental MPs (≤3 μm) in the liver of adult benthopelagic fish Serranus scriba (Linnaeus 1758), caught from three coastal regions in Tunisia distinguished by different patterns of human activity. Polymer composition in fish liver was identified using Raman microspectroscopy. Results revealed differences in the abundance, size distribution and presence of plastic additives over the investigated sites. Polyethylene-vinyl acetate (PEVA: 34% particles/g of tissue), high density polyethylene (HDPE: 24.4%) and the two smaller size classes, i.e. 3-1.2 μm and 1.2-0.45 μm, were the most abundant MPs types and size distribution found, respectively, in Bizerte channel (BC) site (Bizerte city, Tunisia). Moreover, at hepatic level data showed a significant site-dependent cytotoxicity expressed by changes in malondialdehyde (MDA) content, presence of reactive oxygen species (ROS) expressed by altered level of catalase (CAT) and glutathione-S-transferase (GST) activities and in the content of metallothioneins (MTs), as well as genotoxicity by changes in the amount of micronucleus (MN), and neurotoxicity by altered activity of acetylcholinesterase (AChE). A innovative metabolomics analysis was also performed to further investigate the distinct patterns of key metabolite changes in the liver of Serranus scriba. A total of 36 metabolites were significantly affected, mainly involved in energy, amino acid and osmolyte metabolism. These findings emphasised for the first time a close relationship between the source, abundance and size ranges of environmental MPs ≤ 3 μm and their hepatotoxicity in wild organisms." @default.
- W4280496553 created "2022-05-22" @default.
- W4280496553 creator A5003571565 @default.
- W4280496553 creator A5007744538 @default.
- W4280496553 creator A5008326839 @default.
- W4280496553 creator A5032201121 @default.
- W4280496553 creator A5039231656 @default.
- W4280496553 creator A5040554046 @default.
- W4280496553 creator A5040896603 @default.
- W4280496553 creator A5058982734 @default.
- W4280496553 creator A5064682899 @default.
- W4280496553 creator A5075257769 @default.
- W4280496553 creator A5085965961 @default.
- W4280496553 date "2022-09-01" @default.
- W4280496553 modified "2023-10-15" @default.
- W4280496553 title "Metabolomic disorders unveil hepatotoxicity of environmental microplastics in wild fish Serranus scriba (Linnaeus 1758)" @default.
- W4280496553 cites W1503760388 @default.
- W4280496553 cites W1581414347 @default.
- W4280496553 cites W1957200237 @default.
- W4280496553 cites W1963532263 @default.
- W4280496553 cites W1971048984 @default.
- W4280496553 cites W1973708266 @default.
- W4280496553 cites W1975771948 @default.
- W4280496553 cites W2003022112 @default.
- W4280496553 cites W2015102358 @default.
- W4280496553 cites W2015243812 @default.
- W4280496553 cites W2028038991 @default.
- W4280496553 cites W2046620646 @default.
- W4280496553 cites W2047003156 @default.
- W4280496553 cites W2048721503 @default.
- W4280496553 cites W2074043591 @default.
- W4280496553 cites W2080154049 @default.
- W4280496553 cites W2090574221 @default.
- W4280496553 cites W2116464510 @default.
- W4280496553 cites W2156903167 @default.
- W4280496553 cites W2163554310 @default.
- W4280496553 cites W2164526292 @default.
- W4280496553 cites W2182121802 @default.
- W4280496553 cites W2184400106 @default.
- W4280496553 cites W2193763022 @default.
- W4280496553 cites W2218932787 @default.
- W4280496553 cites W2230820137 @default.
- W4280496553 cites W2289382232 @default.
- W4280496553 cites W2318467540 @default.
- W4280496553 cites W2319746598 @default.
- W4280496553 cites W2334656829 @default.
- W4280496553 cites W2418926272 @default.
- W4280496553 cites W2505003366 @default.
- W4280496553 cites W2520216211 @default.
- W4280496553 cites W2530566078 @default.
- W4280496553 cites W2546396707 @default.
- W4280496553 cites W2581031358 @default.
- W4280496553 cites W2581845998 @default.
- W4280496553 cites W2604864918 @default.
- W4280496553 cites W2609067898 @default.
- W4280496553 cites W2611366636 @default.
- W4280496553 cites W2620099204 @default.
- W4280496553 cites W2751806047 @default.
- W4280496553 cites W2754335168 @default.
- W4280496553 cites W2761119328 @default.
- W4280496553 cites W2761590587 @default.
- W4280496553 cites W2793163470 @default.
- W4280496553 cites W2793554595 @default.
- W4280496553 cites W2795342892 @default.
- W4280496553 cites W2795814275 @default.
- W4280496553 cites W2797624594 @default.
- W4280496553 cites W2803337465 @default.
- W4280496553 cites W2885126584 @default.
- W4280496553 cites W2894930695 @default.
- W4280496553 cites W2896026915 @default.
- W4280496553 cites W2911764582 @default.
- W4280496553 cites W2915456106 @default.
- W4280496553 cites W2918895016 @default.
- W4280496553 cites W2919072266 @default.
- W4280496553 cites W2920904424 @default.
- W4280496553 cites W2921025712 @default.
- W4280496553 cites W2928772646 @default.
- W4280496553 cites W2944788079 @default.
- W4280496553 cites W2945727442 @default.
- W4280496553 cites W2946239280 @default.
- W4280496553 cites W2948574679 @default.
- W4280496553 cites W2951492660 @default.
- W4280496553 cites W2965672014 @default.
- W4280496553 cites W2970239463 @default.
- W4280496553 cites W2988186114 @default.
- W4280496553 cites W3016854320 @default.
- W4280496553 cites W3016875002 @default.
- W4280496553 cites W3027761339 @default.
- W4280496553 cites W3036733390 @default.
- W4280496553 cites W3092691161 @default.
- W4280496553 cites W3093922164 @default.
- W4280496553 cites W3113727317 @default.
- W4280496553 cites W3135390961 @default.
- W4280496553 cites W3154868291 @default.
- W4280496553 cites W4200069810 @default.
- W4280496553 cites W4206682079 @default.
- W4280496553 cites W4214918933 @default.
- W4280496553 cites W4221078377 @default.