FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280496651> ?p ?o ?g. }

• W4280496651 endingPage "e1010533" @default.
• W4280496651 startingPage "e1010533" @default.
• W4280496651 abstract "Antagonism of the interferon (IFN)-mediated antiviral state is critical to infection by rabies virus (RABV) and other viruses, and involves interference in the IFN induction and signaling pathways in infected cells, as well as deactivation of the antiviral state in cells previously activated by IFN. The latter is required for viral spread in the host, but the precise mechanisms involved and roles in RABV pathogenesis are poorly defined. Here, we examined the capacity of attenuated and pathogenic strains of RABV that differ only in the IFN-antagonist P protein to overcome an established antiviral state. Importantly, P protein selectively targets IFN-activated phosphorylated STAT1 (pY-STAT1), providing a molecular tool to elucidate specific roles of pY-STAT1. We find that the extended antiviral state is dependent on a low level of pY-STAT1 that appears to persist at a steady state through ongoing phosphorylation/dephosphorylation cycles, following an initial IFN-induced peak. P protein of pathogenic RABV binds and progressively accumulates pY-STAT1 in inactive cytoplasmic complexes, enabling recovery of efficient viral replication over time. Thus, P protein-pY-STAT1 interaction contributes to 'disarming' of the antiviral state. P protein of the attenuated RABV is defective in this respect, such that replication remains suppressed over extended periods in cells pre-activated by IFN. These data provide new insights into the nature of the antiviral state, indicating key roles for residual pY-STAT1 signaling. They also elucidate mechanisms of viral deactivation of antiviral responses, including specialized functions of P protein in selective targeting and accumulation of pY-STAT1." @default.
• W4280496651 created "2022-05-22" @default.
• W4280496651 creator A5006827714 @default.
• W4280496651 creator A5011188004 @default.
• W4280496651 creator A5031501274 @default.
• W4280496651 creator A5040982752 @default.
• W4280496651 creator A5048088527 @default.
• W4280496651 creator A5065135450 @default.
• W4280496651 creator A5067731214 @default.
• W4280496651 creator A5069375840 @default.
• W4280496651 creator A5081755608 @default.
• W4280496651 date "2022-05-16" @default.
• W4280496651 modified "2023-10-01" @default.
• W4280496651 title "Deactivation of the antiviral state by rabies virus through targeting and accumulation of persistently phosphorylated STAT1" @default.
• W4280496651 cites W1542058436 @default.
• W4280496651 cites W1964316194 @default.
• W4280496651 cites W1980817114 @default.
• W4280496651 cites W1980943580 @default.
• W4280496651 cites W1986762728 @default.
• W4280496651 cites W1993191507 @default.
• W4280496651 cites W2005709358 @default.
• W4280496651 cites W2037746465 @default.
• W4280496651 cites W2043316994 @default.
• W4280496651 cites W2048051867 @default.
• W4280496651 cites W2048826278 @default.
• W4280496651 cites W2055279590 @default.
• W4280496651 cites W2059419113 @default.
• W4280496651 cites W2062108803 @default.
• W4280496651 cites W2063088349 @default.
• W4280496651 cites W2068542139 @default.
• W4280496651 cites W2071263748 @default.
• W4280496651 cites W2078841246 @default.
• W4280496651 cites W2085935547 @default.
• W4280496651 cites W2091095196 @default.
• W4280496651 cites W2095966880 @default.
• W4280496651 cites W2098811581 @default.
• W4280496651 cites W2102884496 @default.
• W4280496651 cites W2103858832 @default.
• W4280496651 cites W2105479844 @default.
• W4280496651 cites W2106246506 @default.
• W4280496651 cites W2106927718 @default.
• W4280496651 cites W2111962787 @default.
• W4280496651 cites W2137297639 @default.
• W4280496651 cites W2137872043 @default.
• W4280496651 cites W2144532381 @default.
• W4280496651 cites W2147511779 @default.
• W4280496651 cites W2159370470 @default.
• W4280496651 cites W2160443591 @default.
• W4280496651 cites W2163887454 @default.
• W4280496651 cites W2165849880 @default.
• W4280496651 cites W2168532629 @default.
• W4280496651 cites W2169663885 @default.
• W4280496651 cites W2191051775 @default.
• W4280496651 cites W2195692446 @default.
• W4280496651 cites W2198515723 @default.
• W4280496651 cites W2259579158 @default.
• W4280496651 cites W2290843007 @default.
• W4280496651 cites W2313673876 @default.
• W4280496651 cites W2331720061 @default.
• W4280496651 cites W2491467392 @default.
• W4280496651 cites W2522853733 @default.
• W4280496651 cites W2537296941 @default.
• W4280496651 cites W2561066128 @default.
• W4280496651 cites W2936471740 @default.
• W4280496651 cites W2939595443 @default.
• W4280496651 cites W2986743000 @default.
• W4280496651 cites W3081137289 @default.
• W4280496651 cites W3084156728 @default.
• W4280496651 cites W3087744389 @default.
• W4280496651 cites W3094558943 @default.
• W4280496651 cites W3175893699 @default.
• W4280496651 cites W3181406866 @default.
• W4280496651 cites W4242377601 @default.
• W4280496651 doi "https://doi.org/10.1371/journal.ppat.1010533" @default.
• W4280496651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35576230" @default.
• W4280496651 hasPublicationYear "2022" @default.
• W4280496651 type Work @default.
• W4280496651 citedByCount "2" @default.
• W4280496651 countsByYear W42804966512022 @default.
• W4280496651 crossrefType "journal-article" @default.
• W4280496651 hasAuthorship W4280496651A5006827714 @default.
• W4280496651 hasAuthorship W4280496651A5011188004 @default.
• W4280496651 hasAuthorship W4280496651A5031501274 @default.
• W4280496651 hasAuthorship W4280496651A5040982752 @default.
• W4280496651 hasAuthorship W4280496651A5048088527 @default.
• W4280496651 hasAuthorship W4280496651A5065135450 @default.
• W4280496651 hasAuthorship W4280496651A5067731214 @default.
• W4280496651 hasAuthorship W4280496651A5069375840 @default.
• W4280496651 hasAuthorship W4280496651A5081755608 @default.
• W4280496651 hasBestOaLocation W42804966511 @default.
• W4280496651 hasConcept C104317684 @default.
• W4280496651 hasConcept C11960822 @default.
• W4280496651 hasConcept C140704245 @default.
• W4280496651 hasConcept C140933497 @default.
• W4280496651 hasConcept C159047783 @default.
• W4280496651 hasConcept C178666793 @default.
• W4280496651 hasConcept C181912034 @default.
• W4280496651 hasConcept C2522874641 @default.

• next