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• W4280497046 abstract "Objective: The magnetic resonance imaging (MRI) features of intestinal-type periampullary carcinoma (IPAC) and pancreatobiliary-type periampullary carcinoma (PPAC) were compared and analyzed to discuss the optimal diagnosis scheme. Method: Preoperative MRI images of 59 patients (32 males, 27 females, aged 37-80 years) diagnosed with periampullary carcinoma (PAC) confirmed by surgery and pathology in Nanjing Drum Tower Hospital from January 2017 to July 2020 were retrospectively analyzed. The patients were divided into 21 cases in the IPAC group (11 males, 10 females) and 38 cases in the PPAC group (21 males, 17 females) according to histopathological results. The conventional MRI plain scan signs included in the analysis include lesion morphology, the largest diameter of the lesion, lesion location, duodenal papilla morphology, plain scan lesion signal (with the normal pancreatic signal as reference), diffusion weighted imaging (DWI) signal. Magnetic resonance cholangiopancreatography (MRCP) image signs include the dilatation of common bile duct and main pancreatic duct and quantitative analysis of their diameter, the presence of a round filling defect in the distal end of the common bile duct, the morphology of common bile duct stenosis, the dilatation of lateral branches around the obstructed pancreatic duct, the ductal sign, the distance from the end of the obstructed common bile duct to the duodenal papilla, the distance from the end of the obstructed pancreatic duct to the duodenal papilla, and the angle of the pancreaticobiliary duct. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of single meaningful factors. The MRI features of PAC were summarized according to the significant single factor indicators and were classified into 5 image types. And the diagnostic efficacy of the classification criteria for pathological subtypes of PAC was evaluated by the ROC curve. The DeLong test was used to compare the area under the ROC curve (AUC) of multiple diagnostic methods. Results: In univariate analysis, there were statistically significant differences between IPAC and PPAC in lesion location, duodenal papilla morphology, the circular filling defect in the distal end of the common bile duct, the distance from the obstructed pancreatic duct to the duodenal papilla, the angle of the pancreaticobiliary duct, and lesion signal characteristics on plain T2WI fat suppressant images (all P<0.05). Among the 5 types of MRI images, IPAC is mostly manifested as duodenal papillary nodules(15/21,71.4%), while PPAC is more manifested as pancreatic mass type(18/38,47.4%), thickened common bile duct wall type(9/38,23.7%) or ampullary mass type(9/38,23.7%). Both IPAC(2/21,9.5%) and PPAC(0,0) rarely showed the nodular type of common bile duct lumen. In the DeLong test of the significant univariate index(lesion location, duodenal papilla morphology, the circular filling defect in the distal end of the common bile duct, the distance from obstructed pancreatic duct to duodenal papilla, the angle of the pancreaticobiliary duct, and lesion signal characteristics on plain T2WI fat suppressant images) and the 5 classification of MRI images, the AUC of the 5 classifications of MRI images was 0.932(95%CI:0.867-0.997), which was higher than that of any of the significant univariate indexes (all P<0.05). In addition, the 5 classifications of MRI images have the same high diagnostic power as the logistic regression analysis model(P>0.05). Conclusions: The 5 classification of MRI images can improve the accuracy of differential diagnosis of IPAC and PPAC before surgery, and the diagnostic efficiency is better than any single factor meaningful index and comparable to that of the logistic regression analysis model.目的： 比较分析肠型壶腹周围癌（IPAC）与胰胆管型壶腹周围癌（PPAC）的磁共振成像（MRI）征象特点，探讨最优诊断方案。 方法： 回顾性分析南京鼓楼医院2017年1月至2020年7月，经手术病理确诊为壶腹周围癌（PAC）59例患者（男32例，女27例，年龄37~80岁）的术前MRI图像，将病灶根据组织病理结果分为IPAC组21例（男 11例，女10例）和PPAC组38例（男 21 例，女17例）。纳入分析的MRI常规平扫图像征象包括：病灶形态、病灶最大径、病灶位置、十二指肠乳头形态、平扫病灶信号（以正常胰腺信号作为参照）、弥散加权成像（DWI）信号。磁共振胰胆管水成像（MRCP）图像征象包括：胆总管及主胰管是否扩张及管径定量分析、胆总管远端内有无类圆形充盈缺损、胆总管狭窄形态、梗阻胰管周围是否有扩张侧支、管征、截断胆总管末端到十二指肠乳头距离、截断胰管末端到十二指肠乳头距离和胰胆管角度。采用受试者工作特征（ROC）曲线评价有意义单因素的诊断效能。依据有意义的单因素指标，总结PAC的MRI征象特点，将PAC的MRI征象特征归纳为影像5分型。并采用ROC曲线评价该分型标准对PAC病理亚型的诊断效能。采用DeLong 检验比较多种诊断方法的ROC 曲线下面积（AUC）。 结果： 在单因素分析中，IPAC与PPAC在病灶位置、十二指肠乳头形态、胆总管远端内类圆形充盈缺损、截断胰管末端到十二指肠乳头距离、胰胆管角度和平扫T 2加权成像（T2WI）脂肪抑制图像上病灶信号特点间的差异均有统计学意义（均P<0.05）。在MRI影像5分型中，IPAC多表现为十二指肠乳头结节型（15/21，71.4%），PPAC更多表现为胰腺肿块型（18/38，47.4%）、胆总管壁增厚型（9/38，23.7%）或壶腹部肿块型（9/38，23.7%），IPAC（2/21，9.5%）与PPAC（0，0）均较少表现为胆总管腔内结节型。在有意义单因素指标（病灶位置、十二指肠乳头形态、胆总管远端内类圆形充盈缺损、截断胰管末端到十二指肠乳头距离、胰胆管角度、平扫T2WI脂肪抑制图像上病灶信号特点）与MRI影像5分型的DeLong 检验中，MRI影像5分型的AUC为0.932（95%CI：0.867~0.997），高于任一有意义单因素指标（均P<0.05）。另外，MRI影像5分型与logistic回归分析模型具有同等高的诊断效能（P>0.05）。 结论： MRI影像5分型可以在术前提高鉴别诊断IPAC及PPAC的准确率，其诊断效能优于任一单因素有意义指标，且可与logistic回归分析模型的诊断效能相媲美。." @default.
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• W4280497046 date "2022-05-17" @default.
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• W4280497046 title "[Contrastive study on MRI signs of intestinal and pancreatobiliary-type periampullary carcinoma]." @default.
• W4280497046 doi "https://doi.org/10.3760/cma.j.cn112137-20210817-01864" @default.
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