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- W4280497518 abstract "ABSTRACT Ultraviolet (UV), particularly UVB, is widely used in the treatment of skin diseases including psoriasis, atopic dermatitis, vitiligo, mycosis fungoides and pruritus. Recently, there has been a trend of replacing broad‐band UVB (BB‐UVB) units with narrow‐band UVB (NB‐UVB), as studies have demonstrated that NB‐UVB is more efficacious in the treatment of psoriasis. The purpose of this study is to evaluate the biological effects and transcriptome changes induced by light‐emitting diode‐based NB‐UVB (NB‐UVB LED) phototherapy. Cell viability and the cell migration ability were significantly decreased posttreatment, as well as apoptosis and ROS levels were remarkably increased. NB‐UVB‐induced S phase arrest was observed 12 h postirradiation. Bioinformatics analysis of transcriptome sequencing data revealed that NB‐UVB LED irradiation induced dose‐depended changes in multiple key signaling pathways, such as PI3K and cytoskeletal‐related pathways. The depolymerization of cytoskeleton induced by NB‐UVB was observed 24 h posttreatment. In addition, the expression levels of cytoskeleton‐related proteins FN1, ITGB4, ITGA1, RAC2 and DOCK1 decreased significantly 12 h after irradiation. Our results indicated that NB‐UVB LED may serve as a novel option for the development of NB‐UVB phototherapy devices." @default.
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- W4280497518 date "2022-05-30" @default.
- W4280497518 modified "2023-09-26" @default.
- W4280497518 title "Evaluation of Biological Effects and Transcriptome Changes Induced by <scp>LED</scp>‐Based Narrow‐Band <scp>UVB</scp> Phototherapy" @default.
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- W4280497518 doi "https://doi.org/10.1111/php.13643" @default.
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