Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280497724> ?p ?o ?g. }
- W4280497724 endingPage "3445" @default.
- W4280497724 startingPage "3423" @default.
- W4280497724 abstract "Obesity, which has unknown pathogenesis, can increase the frequency and seriousness of acute myocardial infarction (AMI). This study evaluated effect of Huayu Qutan Recipe (HQR) pretreatment on myocardial apoptosis induced by AMI by regulating mitochondrial function via PI3K/Akt/Bad pathway in rats with obesity. For in vivo experiments, 60 male rats were randomly divided into 6 groups: sham group, AMI group, AMI (obese) group, 4.5, 9.0 and 18.0 g/kg/d HQR groups. The models fed on HQR with different concentrations for 2 weeks before AMI. For in vitro experiments, the cardiomyocytes line (H9c2) was used. Cells were pretreated with palmitic acid (PA) for 24 h, then to build hypoxia model followed by HQR-containing serum for 24 h. Related indicators were also detected. In vivo, HQR can lessen pathohistological damage and apoptosis after AMI. In addition, HQR improves blood fat levels, cardiac function, inflammatory factor, the balance of oxidation and antioxidation, as well as lessen infarction in rats with obesity after AMI. Meanwhile, HQR can diminish myocardial cell death by improving mitochondrial function via PI3K/Akt/Bad pathway activation. In vitro, HQR inhibited H9c2 cells apoptosis, improved mitochondrial function and activated the PI3K/Akt/Bad pathway, but effects can be peripeteiad by LY294002. Myocardial mitochondrial dysfunction occurs following AMI and can lead to myocardial apoptosis, which can be aggravated by obesity. HQR can relieve myocardial apoptosis by improving mitochondrial function via the PI3K/Akt/Bad pathway in rats with obesity." @default.
- W4280497724 created "2022-05-22" @default.
- W4280497724 creator A5000098283 @default.
- W4280497724 creator A5001666712 @default.
- W4280497724 creator A5018742393 @default.
- W4280497724 creator A5021683414 @default.
- W4280497724 creator A5030088504 @default.
- W4280497724 creator A5043422743 @default.
- W4280497724 creator A5060712147 @default.
- W4280497724 creator A5071505868 @default.
- W4280497724 creator A5071533886 @default.
- W4280497724 creator A5076489905 @default.
- W4280497724 creator A5082481234 @default.
- W4280497724 date "2022-05-13" @default.
- W4280497724 modified "2023-10-13" @default.
- W4280497724 title "A possible new activator of PI3K‐Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction" @default.
- W4280497724 cites W1197081707 @default.
- W4280497724 cites W163606371 @default.
- W4280497724 cites W1889456003 @default.
- W4280497724 cites W1966861384 @default.
- W4280497724 cites W1983738681 @default.
- W4280497724 cites W1988449494 @default.
- W4280497724 cites W2033661266 @default.
- W4280497724 cites W2038099459 @default.
- W4280497724 cites W2038540078 @default.
- W4280497724 cites W2054835198 @default.
- W4280497724 cites W2076693703 @default.
- W4280497724 cites W2077600892 @default.
- W4280497724 cites W2090122461 @default.
- W4280497724 cites W2099358601 @default.
- W4280497724 cites W2107277218 @default.
- W4280497724 cites W2113515610 @default.
- W4280497724 cites W2123875620 @default.
- W4280497724 cites W2161172483 @default.
- W4280497724 cites W2161590269 @default.
- W4280497724 cites W2165884492 @default.
- W4280497724 cites W2166432730 @default.
- W4280497724 cites W2192080449 @default.
- W4280497724 cites W2329681473 @default.
- W4280497724 cites W2362607290 @default.
- W4280497724 cites W2395688680 @default.
- W4280497724 cites W2412207461 @default.
- W4280497724 cites W2544767601 @default.
- W4280497724 cites W2575523144 @default.
- W4280497724 cites W2581314540 @default.
- W4280497724 cites W2582023673 @default.
- W4280497724 cites W2589290067 @default.
- W4280497724 cites W2600742684 @default.
- W4280497724 cites W2608643910 @default.
- W4280497724 cites W2736032980 @default.
- W4280497724 cites W2756062256 @default.
- W4280497724 cites W2777606180 @default.
- W4280497724 cites W2793543178 @default.
- W4280497724 cites W2809077470 @default.
- W4280497724 cites W2809295497 @default.
- W4280497724 cites W2809873157 @default.
- W4280497724 cites W2883109078 @default.
- W4280497724 cites W2889393736 @default.
- W4280497724 cites W2930131512 @default.
- W4280497724 cites W2939452227 @default.
- W4280497724 cites W2941453678 @default.
- W4280497724 cites W2942329965 @default.
- W4280497724 cites W2946214598 @default.
- W4280497724 cites W2947930584 @default.
- W4280497724 cites W2960686802 @default.
- W4280497724 cites W2996692548 @default.
- W4280497724 cites W3007891666 @default.
- W4280497724 cites W3011364962 @default.
- W4280497724 cites W3011824135 @default.
- W4280497724 cites W3036964362 @default.
- W4280497724 cites W3041140855 @default.
- W4280497724 cites W3045717238 @default.
- W4280497724 cites W3087795317 @default.
- W4280497724 cites W4280497724 @default.
- W4280497724 doi "https://doi.org/10.1111/jcmm.17353" @default.
- W4280497724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35567290" @default.
- W4280497724 hasPublicationYear "2022" @default.
- W4280497724 type Work @default.
- W4280497724 citedByCount "2" @default.
- W4280497724 countsByYear W42804977242022 @default.
- W4280497724 crossrefType "journal-article" @default.
- W4280497724 hasAuthorship W4280497724A5000098283 @default.
- W4280497724 hasAuthorship W4280497724A5001666712 @default.
- W4280497724 hasAuthorship W4280497724A5018742393 @default.
- W4280497724 hasAuthorship W4280497724A5021683414 @default.
- W4280497724 hasAuthorship W4280497724A5030088504 @default.
- W4280497724 hasAuthorship W4280497724A5043422743 @default.
- W4280497724 hasAuthorship W4280497724A5060712147 @default.
- W4280497724 hasAuthorship W4280497724A5071505868 @default.
- W4280497724 hasAuthorship W4280497724A5071533886 @default.
- W4280497724 hasAuthorship W4280497724A5076489905 @default.
- W4280497724 hasAuthorship W4280497724A5082481234 @default.
- W4280497724 hasBestOaLocation W42804977242 @default.
- W4280497724 hasConcept C111566952 @default.
- W4280497724 hasConcept C126322002 @default.
- W4280497724 hasConcept C134018914 @default.
- W4280497724 hasConcept C185592680 @default.
- W4280497724 hasConcept C190283241 @default.