FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280497821> ?p ?o ?g. }

• W4280497821 abstract "Background Amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R) has emerged as a clinical prognostic marker for clinical and research purposes in amyotrophic lateral sclerosis (ALS). However, tools for predicting disease progression are still underdeveloped. The aim of this study was to mathematically model ALS progression to provide a reliable and personalized approach to the prognosis for ALS patients. Also, it aimed to provide a reliable prediction tool for the current and newly diagnosed patients. Methods Twenty patients from the South-East England Amyotrophic Lateral Sclerosis register (SEALS) database were included in the analysis. A non-linear logistic regression model was used to describe disease progression from baseline health to the theoretical maximum disease. The reliability of predicted variables and correlation between model parameters were assessed separately for each subject. Results The logistic regression model best described the disease progression in patients with a high progression rate. Most notably, the model fitted better when a patient has progressed enough to approximately the midpoint of the functional rating scale. The model failed to characterize the disease course in patients defined as slow progressors. Furthermore, the linear relationship between the rate of progression and time since onset at ALFRS-R score of 24 was evident in 65% of patients. Conclusion These results indicate that the rate of disease progression and time when ALSFRS-R declines to half the maximum score are correlated with functional outcomes. Nonetheless, the logistic model failed to describe disease course in patients with slow progression rates. Different rates of progression can be attributed to the genetic heterogeneity of ALS. Thus, clinicians and patients can benefit from adding a gene factor to the equation. With the outlined limitations, the model can provide a good prognostic tool." @default.
• W4280497821 created "2022-05-22" @default.
• W4280497821 creator A5023608364 @default.
• W4280497821 date "2022-05-10" @default.
• W4280497821 modified "2023-10-05" @default.
• W4280497821 title "Modeling Amyotrophic Lateral Sclerosis Progression: Logic in the Logit" @default.
• W4280497821 cites W2001432662 @default.
• W4280497821 cites W2003547409 @default.
• W4280497821 cites W2015037203 @default.
• W4280497821 cites W2021988387 @default.
• W4280497821 cites W2053241895 @default.
• W4280497821 cites W2066828509 @default.
• W4280497821 cites W2072204165 @default.
• W4280497821 cites W2083879405 @default.
• W4280497821 cites W2108381339 @default.
• W4280497821 cites W2124995611 @default.
• W4280497821 cites W2131461502 @default.
• W4280497821 cites W2133305315 @default.
• W4280497821 cites W2165360324 @default.
• W4280497821 cites W2171305248 @default.
• W4280497821 cites W2308131719 @default.
• W4280497821 cites W2398498214 @default.
• W4280497821 cites W2407348554 @default.
• W4280497821 cites W2593282276 @default.
• W4280497821 cites W2597921152 @default.
• W4280497821 cites W2612214304 @default.
• W4280497821 cites W2913609543 @default.
• W4280497821 cites W4226095724 @default.
• W4280497821 doi "https://doi.org/10.7759/cureus.24887" @default.
• W4280497821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35698688" @default.
• W4280497821 hasPublicationYear "2022" @default.
• W4280497821 type Work @default.
• W4280497821 citedByCount "2" @default.
• W4280497821 countsByYear W42804978212022 @default.
• W4280497821 countsByYear W42804978212023 @default.
• W4280497821 crossrefType "journal-article" @default.
• W4280497821 hasAuthorship W4280497821A5023608364 @default.
• W4280497821 hasBestOaLocation W42804978211 @default.
• W4280497821 hasConcept C105795698 @default.
• W4280497821 hasConcept C126322002 @default.
• W4280497821 hasConcept C151956035 @default.
• W4280497821 hasConcept C1862650 @default.
• W4280497821 hasConcept C2779134260 @default.
• W4280497821 hasConcept C2780596555 @default.
• W4280497821 hasConcept C33923547 @default.
• W4280497821 hasConcept C71924100 @default.
• W4280497821 hasConcept C83849319 @default.
• W4280497821 hasConcept C99508421 @default.
• W4280497821 hasConceptScore W4280497821C105795698 @default.
• W4280497821 hasConceptScore W4280497821C126322002 @default.
• W4280497821 hasConceptScore W4280497821C151956035 @default.
• W4280497821 hasConceptScore W4280497821C1862650 @default.
• W4280497821 hasConceptScore W4280497821C2779134260 @default.
• W4280497821 hasConceptScore W4280497821C2780596555 @default.
• W4280497821 hasConceptScore W4280497821C33923547 @default.
• W4280497821 hasConceptScore W4280497821C71924100 @default.
• W4280497821 hasConceptScore W4280497821C83849319 @default.
• W4280497821 hasConceptScore W4280497821C99508421 @default.
• W4280497821 hasLocation W42804978211 @default.
• W4280497821 hasLocation W42804978212 @default.
• W4280497821 hasLocation W42804978213 @default.
• W4280497821 hasOpenAccess W4280497821 @default.
• W4280497821 hasPrimaryLocation W42804978211 @default.
• W4280497821 hasRelatedWork W1991716304 @default.
• W4280497821 hasRelatedWork W2389709268 @default.
• W4280497821 hasRelatedWork W2416894208 @default.
• W4280497821 hasRelatedWork W2521404633 @default.
• W4280497821 hasRelatedWork W2974773944 @default.
• W4280497821 hasRelatedWork W3205284487 @default.
• W4280497821 hasRelatedWork W4284671965 @default.
• W4280497821 hasRelatedWork W4321436211 @default.
• W4280497821 hasRelatedWork W4386022403 @default.
• W4280497821 hasRelatedWork W98669030 @default.
• W4280497821 isParatext "false" @default.
• W4280497821 isRetracted "false" @default.
• W4280497821 workType "article" @default.