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- W4280498072 endingPage "779" @default.
- W4280498072 startingPage "769" @default.
- W4280498072 abstract "Ultrasonic neurostimulation is a potentially potent noninvasive therapy, whose mechanism has yet to be elucidated. We designed a system capable of applying ultrasound with minimal reflections to neuronal cultures. Synaptic transmission was pharmacologically controlled, eliminating network effects, enabling examination of single-cell processes. Short single pulses of low-intensity ultrasound were applied, and time-locked responses were examined using calcium imaging.Low-pressure (0.35 MPa) ultrasound directly stimulated ∼20% of pharmacologically disconnected neurons, regardless of membrane poration. Stimulation was resistant to the blockade of several purinergic receptor and mechanosensitive ion channel types. Stimulation was blocked, however, by suppression of action potentials. Surprisingly, even extremely short (4 μs) pulses were effective, stimulating ∼8% of the neurons. Lower-pressure pulses (0.35 MPa) were less effective than higher-pressure ones (0.65 MPa). Attrition effects dominated, with no indication of compromised viability.Our results detract from theories implicating cavitation, heating, non-transient membrane pores >1.5 nm, pre-synaptic release, or gradual effects. They implicate a post-synaptic mechanism upstream of the action potential, and narrow down the list of possible targets involved." @default.
- W4280498072 created "2022-05-22" @default.
- W4280498072 creator A5041272979 @default.
- W4280498072 creator A5067777615 @default.
- W4280498072 date "2022-05-01" @default.
- W4280498072 modified "2023-09-25" @default.
- W4280498072 title "Mechanistic insights into ultrasonic neurostimulation of disconnected neurons using single short pulses" @default.
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- W4280498072 doi "https://doi.org/10.1016/j.brs.2022.05.004" @default.
- W4280498072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35561960" @default.
- W4280498072 hasPublicationYear "2022" @default.
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