FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280498436> ?p ?o ?g. }

• W4280498436 endingPage "1150" @default.
• W4280498436 startingPage "1136" @default.
• W4280498436 abstract "Opioids are the gold standard for chronic and acute pain management; however, their consequence on gastric function is relatively understudied. Opioid users have a higher incidence of gastric dysfunction, worse quality of life, increased hospitalizations, and increased use of antiemetic and pain modulator medications. The current study shows that morphine treatment in the murine model results in greater disruption of gastric epithelial cell morphology, increased gastric cell apoptosis, elevated inflammatory cytokines, and matrix metallopeptidase-9 secretion. Morphine treatment also increases gastric acid secretion and causes delays in gastric emptying. Moreover, morphine treatment causes an increase in systemic IL-6 level, which plays an important role in morphine-induced delayed gastric emptying and gastric damage. IL-6 knockout mice show a significant level of reduction in morphine-induced gastric delaying, acid retention, and gastric damage. Thus, morphine-mediated gastric damage is a consequence of the accumulation of acid in the stomach due to increased gastric acid secretion and delayed gastric emptying. Treatment with a proton pump inhibitor resulted in a significant reduction in morphine-induced gastric inflammation, gastric delaying, and improved morphine tolerance. Hence, these studies attribute morphine-mediated induction in gastric acidity and inflammatory cytokines as drivers for morphine-associated gastric pathology and show the therapeutic use of proton pump inhibitors as an inexpensive approach for clinical management of morphine-associated pathophysiology and analgesic tolerance." @default.
• W4280498436 created "2022-05-22" @default.
• W4280498436 creator A5009648827 @default.
• W4280498436 creator A5062747949 @default.
• W4280498436 creator A5077274375 @default.
• W4280498436 creator A5085548742 @default.
• W4280498436 date "2022-08-01" @default.
• W4280498436 modified "2023-10-17" @default.
• W4280498436 title "Opioid Use in Murine Model Results in Severe Gastric Pathology that May Be Attenuated by Proton Pump Inhibition" @default.
• W4280498436 cites W1523516240 @default.
• W4280498436 cites W1581589245 @default.
• W4280498436 cites W1613864109 @default.
• W4280498436 cites W1665800944 @default.
• W4280498436 cites W1824025539 @default.
• W4280498436 cites W1967956419 @default.
• W4280498436 cites W1973640136 @default.
• W4280498436 cites W1975042970 @default.
• W4280498436 cites W1979294279 @default.
• W4280498436 cites W1986654088 @default.
• W4280498436 cites W1986852617 @default.
• W4280498436 cites W1994679852 @default.
• W4280498436 cites W2005707246 @default.
• W4280498436 cites W2006913858 @default.
• W4280498436 cites W2018777427 @default.
• W4280498436 cites W2025605750 @default.
• W4280498436 cites W2037392993 @default.
• W4280498436 cites W2043860936 @default.
• W4280498436 cites W2044462492 @default.
• W4280498436 cites W2045352498 @default.
• W4280498436 cites W2045828366 @default.
• W4280498436 cites W2048566698 @default.
• W4280498436 cites W2053031729 @default.
• W4280498436 cites W2063811262 @default.
• W4280498436 cites W2064552381 @default.
• W4280498436 cites W2070287417 @default.
• W4280498436 cites W2079647131 @default.
• W4280498436 cites W2081188577 @default.
• W4280498436 cites W2088402690 @default.
• W4280498436 cites W2096716094 @default.
• W4280498436 cites W2102998161 @default.
• W4280498436 cites W2106546953 @default.
• W4280498436 cites W2121890134 @default.
• W4280498436 cites W2129787366 @default.
• W4280498436 cites W2143051404 @default.
• W4280498436 cites W2144553116 @default.
• W4280498436 cites W2167261475 @default.
• W4280498436 cites W2171451849 @default.
• W4280498436 cites W2278715806 @default.
• W4280498436 cites W2410013559 @default.
• W4280498436 cites W2410687066 @default.
• W4280498436 cites W2414328228 @default.
• W4280498436 cites W2557340009 @default.
• W4280498436 cites W2592902238 @default.
• W4280498436 cites W2778787504 @default.
• W4280498436 cites W2800449273 @default.
• W4280498436 cites W2805365360 @default.
• W4280498436 cites W2807423072 @default.
• W4280498436 cites W2905110859 @default.
• W4280498436 cites W2951182767 @default.
• W4280498436 cites W2990337693 @default.
• W4280498436 cites W3192077053 @default.
• W4280498436 cites W4245344895 @default.
• W4280498436 doi "https://doi.org/10.1016/j.ajpath.2022.04.005" @default.
• W4280498436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35605643" @default.
• W4280498436 hasPublicationYear "2022" @default.
• W4280498436 type Work @default.
• W4280498436 citedByCount "5" @default.
• W4280498436 countsByYear W42804984362022 @default.
• W4280498436 countsByYear W42804984362023 @default.
• W4280498436 crossrefType "journal-article" @default.
• W4280498436 hasAuthorship W4280498436A5009648827 @default.
• W4280498436 hasAuthorship W4280498436A5062747949 @default.
• W4280498436 hasAuthorship W4280498436A5077274375 @default.
• W4280498436 hasAuthorship W4280498436A5085548742 @default.
• W4280498436 hasBestOaLocation W42804984361 @default.
• W4280498436 hasConcept C126322002 @default.
• W4280498436 hasConcept C170493617 @default.
• W4280498436 hasConcept C2776914184 @default.
• W4280498436 hasConcept C2777389121 @default.
• W4280498436 hasConcept C2777504413 @default.
• W4280498436 hasConcept C2779422922 @default.
• W4280498436 hasConcept C2780820201 @default.
• W4280498436 hasConcept C2781063702 @default.
• W4280498436 hasConcept C2781443798 @default.
• W4280498436 hasConcept C3020479747 @default.
• W4280498436 hasConcept C71924100 @default.
• W4280498436 hasConcept C90924648 @default.
• W4280498436 hasConcept C98274493 @default.
• W4280498436 hasConceptScore W4280498436C126322002 @default.
• W4280498436 hasConceptScore W4280498436C170493617 @default.
• W4280498436 hasConceptScore W4280498436C2776914184 @default.
• W4280498436 hasConceptScore W4280498436C2777389121 @default.
• W4280498436 hasConceptScore W4280498436C2777504413 @default.
• W4280498436 hasConceptScore W4280498436C2779422922 @default.
• W4280498436 hasConceptScore W4280498436C2780820201 @default.
• W4280498436 hasConceptScore W4280498436C2781063702 @default.
• W4280498436 hasConceptScore W4280498436C2781443798 @default.
• W4280498436 hasConceptScore W4280498436C3020479747 @default.

• next