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• W4280498750 abstract "Summary Decreasing dietary intake of methionine exerts robust anti-adiposity effects in rodents but modest effects in humans. Since cysteine can be synthesized from methionine, animal diets are formulated by decreasing methionine and eliminating cysteine. Such diets exert both methionine restriction (MR) and cysteine restriction (CR), i.e., sulfur amino acid restriction (SAAR). Contrarily, human diets used in clinical studies did not eliminate cysteine and thus might have exerted only MR. Epidemiological studies positively correlate body adiposity with plasma cysteine but not with methionine, suggesting that CR, but not MR, is responsible for the antiadiposity effects of SAAR in rodents. Whether this is true, and if so, the underlying mechanisms are unknown. Using multiple diets with variable concentrations of methionine and cysteine, we demonstrate that the anti-adiposity effects of SAAR are due to CR. CR increased serinogenesis (serine biosynthesis from non-glucose substrates) by diverting substrates from glyceroneogenesis, essential for fatty acid/triglyceride cycling. Molecular data suggest that the CR results in glutathione depletion, which induces Nrf2 and downstream targets Phgdh (the serine biosynthetic enzyme) and Pepck-M. Using multiple mouse models, we show that the magnitude of SAAR-induced changes in molecular markers depends on dietary fat concentration (60 fat>10% fat), gender (males>females), and age-at-onset (young>adult). Our findings are translationally relevant as we found a negative correlation of plasma serine with triglycerides and metabolic syndrome criteria in a cross-sectional epidemiological study. SAAR-like diets with high polyunsaturated fatty acids increased plasma serine in a short-term human feeding study. Serinogenesis might be a potential target to correct hypertriglyceridemia." @default.
• W4280498750 created "2022-05-22" @default.
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• W4280498750 date "2022-05-15" @default.
• W4280498750 modified "2023-10-15" @default.
• W4280498750 title "Cysteine Restriction-Specific Effects of Sulfur Amino Acid Restriction on Lipid Metabolism" @default.
• W4280498750 cites W1511013913 @default.
• W4280498750 cites W175506309 @default.
• W4280498750 cites W178702484 @default.
• W4280498750 cites W1831301545 @default.
• W4280498750 cites W1940180868 @default.
• W4280498750 cites W19441132 @default.
• W4280498750 cites W1967647423 @default.
• W4280498750 cites W1973113504 @default.
• W4280498750 cites W1973735828 @default.
• W4280498750 cites W1978613122 @default.
• W4280498750 cites W1983397453 @default.
• W4280498750 cites W1985118273 @default.
• W4280498750 cites W1993561257 @default.
• W4280498750 cites W1996370072 @default.
• W4280498750 cites W2001782886 @default.
• W4280498750 cites W2007064404 @default.
• W4280498750 cites W2009542550 @default.
• W4280498750 cites W2022215953 @default.
• W4280498750 cites W2022799160 @default.
• W4280498750 cites W2029477556 @default.
• W4280498750 cites W2033794975 @default.
• W4280498750 cites W2037164945 @default.
• W4280498750 cites W2041923593 @default.
• W4280498750 cites W2046082189 @default.
• W4280498750 cites W2048594557 @default.
• W4280498750 cites W2051522090 @default.
• W4280498750 cites W2054129051 @default.
• W4280498750 cites W2062760324 @default.
• W4280498750 cites W2063234848 @default.
• W4280498750 cites W2066051121 @default.
• W4280498750 cites W2076076587 @default.
• W4280498750 cites W2080424087 @default.
• W4280498750 cites W2081136502 @default.
• W4280498750 cites W2086843338 @default.
• W4280498750 cites W2091877194 @default.
• W4280498750 cites W2093487114 @default.
• W4280498750 cites W2094431924 @default.
• W4280498750 cites W2100474316 @default.
• W4280498750 cites W2126524529 @default.
• W4280498750 cites W2129678541 @default.
• W4280498750 cites W2130717716 @default.
• W4280498750 cites W2133559912 @default.
• W4280498750 cites W2136906985 @default.
• W4280498750 cites W2136925952 @default.
• W4280498750 cites W2137335846 @default.
• W4280498750 cites W2151504182 @default.
• W4280498750 cites W2151853260 @default.
• W4280498750 cites W2156982258 @default.
• W4280498750 cites W2169964747 @default.
• W4280498750 cites W2173466127 @default.
• W4280498750 cites W2207241376 @default.
• W4280498750 cites W2237640945 @default.
• W4280498750 cites W2346592443 @default.
• W4280498750 cites W2398584588 @default.
• W4280498750 cites W2407310426 @default.
• W4280498750 cites W2464767034 @default.
• W4280498750 cites W2543633483 @default.
• W4280498750 cites W2560805164 @default.
• W4280498750 cites W2593804395 @default.
• W4280498750 cites W2607792748 @default.
• W4280498750 cites W2610765860 @default.
• W4280498750 cites W2690859775 @default.
• W4280498750 cites W2751811196 @default.
• W4280498750 cites W2775374738 @default.
• W4280498750 cites W2780835726 @default.
• W4280498750 cites W2789220675 @default.
• W4280498750 cites W2790803800 @default.
• W4280498750 cites W2792877870 @default.
• W4280498750 cites W2795013773 @default.
• W4280498750 cites W2807703685 @default.
• W4280498750 cites W2900782123 @default.
• W4280498750 cites W2943656785 @default.
• W4280498750 cites W2955916488 @default.
• W4280498750 cites W2964871068 @default.
• W4280498750 cites W2967764163 @default.
• W4280498750 cites W2972667145 @default.
• W4280498750 cites W2974940000 @default.

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